Maneta-Peyret et al.(1010. Maneta-Peyret L, Kitsiouli E, Lekka M, Nakos G, Cassagne C.
Autoantibodies to lipids in bronchoalveolar lavage fluid of patients with acute
respiratory distress syndrome. Crit Care Med. 2001;29(10):1950-4.)
|
Prospective |
27 patients mechanically ventilated, nine patients with ARDS and 18
controls |
To investigate the presence of aPL in BAL of ARDS patients. |
IgG phosphatidic acid and phosphatidylserine were found only in BAL of
ARDS patients. |
|
Wenzel et al.(1111. Wenzel C, Stoiser B, Locker GJ, Laczika K, Quehenberger P, Kapiotis
S, et al. Frequent development of lupus anticoagulants in critically ill patients
treated under intensive care conditions. Crit Care Med.
2002;30(4):763-70.)
|
Prospective |
51 ICU patients |
To investigate how often a prolongation of the aPTT in critically ill
patients is caused by LAC and to identify events related to this. |
52.9% of LAC +. Sepsis and vasoactive amines were related to LAC + (p =
0.006 e p=0.03, respectively). |
63% were transient antibodies. There was no difference in the mortality
rate between LAC + and -. |
Williams et al.(1212. Williams FM, Chinn S, Hughes GR, Leach RM. Critical illness in
systemic lupus erythematosus and the antiphospholipid syndrome. Ann Rheum Dis.
2002;61(5):414-21.)
|
Retrospective |
61 patients with SLE and/or APS admitted at ICU |
To evaluate admission causes and prognosis of these patients. |
The main cause of admission was infection (41%). 58% of patients
developed renal dysfunction. |
APS did not lead to renal dysfunction or changes in hospital mortality
but reduced long-term mortality. |
Wiedermann et al.(1313. Wiedermann FJ, Lederer W, Mayr AJ, Sepp N, Herold M, Schobersberger
W. Prospective observational study of antiphospholipid antibodies in acute lung
injury and acute respiratory distress syndrome: comparison with catastrophic
antiphospholipid syndrome. Lupus. 2003;12(6):462-7.)
|
Prospective |
27 patients with ARDS without APS history |
To evaluate the aPL presence in BAL or blood of these patients. |
Low titles aPL were found in the BAL and blood of these patients. There
was no difference related to severity disease. |
The authors did not compare the patient group with controls |
Aldawood et al.(1414. Aldawood AS, Crowther M, Jaeschke R, Dabbagh O, Alkhairy K, Baharoon
S, et al. The incidence and impact of lupus anticoagulants among patients in the
intensive care unit. Saudi Med J. 2005;26(12):1994-5.)
|
Prospective |
155 ICU patients |
To investigate how often a prolongation of the aPTT in critically ill
patients is caused by LAC and to identify events related to this. |
77% of patients were LAC +. Sepsis and vasoactive amines were related to
LAC +. |
LAC presence was transitory. Mortality rate was 46% versus 5.6% between
LAC + and - (p=0.0004) |
Nakos et al.(1515. Nakos G, Tziakou E, Maneta-Peyret L, Nassis C, Lekka ME.
Anti-phospholipid antibodies in serum from patients with Guillain-Barré syndrome.
Intensive Care Med. 2005;31(10):1401-8.)
|
Prospective |
9 patients with GBS admitted at ICU |
To evaluate the relationship between GBS and aPL presence. |
aPL were found in all GBS patients, and no control patient was aPL
positive. |
The aPL levels decreased with treatment. There was no relationship with
prognosis. |
Salluh et al.(1616. Salluh JI, Soares M, De Meis E. Antiphospholipid antibodies and
multiple organ failure in critically ill cancer patients. Clinics (São Paulo).
2009;64(2):79-82.)
|
Retrospective case series |
18 cancer patients with SIRS/sepsis and thrombotic events |
To describe the clinical outcomes and thrombotic events in a series of
critically ill aPL positive cancer patients. |
100% of patients were positive for LAC e 11% for aCL. Acrocyanosis was
present in 18 patients. Arterial and venous thromboses were found in nine
and five patients, respectively. |
All patients developed MOF during the ICU stay, with a hospital
mortality rate of 72% (13/18). |
Vassalo et al.(1717. Vassalo J, Spector N, de Meis E, Rabello LS, Rosolem MM, do Brasil
PE, et al. Antiphospholipid antibodies in critically ill patients with cancer: A
prospective cohort study. J Crit Care. 2014 Feb 14. [Epub ahead of
print])
|
Prospective |
95 cancer patients admitted in ICU |
To evaluate the prevalence and prognostic impact of aPL in critically
ill patients with cancer. |
LAC was present in 61% of patients. aPL were not associated with either
thrombosis or mortality. However, aPL + patients had a greater need of
renal replacement therapy (33% versus 8%, p = 0.017). |
Higher SOFA scores, medical admissions and D-dimer >500 ng/dl were
independently associated with mortality. |