NSAIDs/COX inhibitor |
Anil et al., 201611 Anil A, Kaya FN, Yavascaoglu B, Mercanoğlu Efe E, Türker G, Demirci A. Comparison of postoperative analgesic efficacy of intraoperative single-dose intravenous administration of dexketoprofen trometamol and diclofenac sodium in laparoscopic cholecystectomy. J Clin Anesth. 2016;32:127-33.
|
60/2 |
Dexketoprofen trometamol (vs. diclofenac) |
ǂ |
§ |
ǂ |
Fleckenstein et al., 201577 Fleckenstein J, Kohls N, Evtouchenko E, Lehmeyer L, Kramer S, Lang PM, et al. No effect of the cyclooxygenase-2 inhibitor etoricoxib on pre-emptive and post-operative analgesia in visceral surgery: results of a randomized controlled trial. Eur J Pain. 2016;20(2):186-95.
|
103/2 |
Etoricoxib (vs. placebo) |
ǂ |
ǂ |
ǂ |
Shuying et al., 201488 Shuying L, Xiao W, Peng L, Tao Z, Ziying L, Liang Z. Preoperative intravenous parecoxib reduces length of stay on ambulatory laparoscopic cholecystectomy. Int J Surg. 2014;12(5):464-8.
|
120/3 |
Parecoxib before anesthetic induction (vs. parecoxib after gallbladder removal or vs. placebo) |
+ |
§ |
ǂ |
Gautam et al., 201499 Gautam S, Agarwal A, Das PK, Agarwal A, Kumar S, Khuba S. Evaluation of the efficacy of methylprednisolone, etoricoxib and a combination of the two substances to attenuate postoperative pain and PONV in patients undergoing laparoscopic cholecystectomy: a prospective, randomized, placebo-controlled trial. Korean J Pain. 2014;27(3):278-84.
|
120/4 |
Etoricoxib with methylprednisolone/etoricoxib/ methylprednisolone (vs. placebo) |
+ |
+ |
ǂ |
Kouroukli et al., 20131010 Kouroukli I, Zompolas V, Tsekoura V, Papazoglou I, Louizos A, Panaretou V. Comparison between lornoxicam quick-release and parecoxib for post-operative analgesia after laparoscopic cholecystectomy: a prospective randomized, placebo-controlled trial. J Anaesthesiol Clin Pharmacol. 2013;29(4):485-90.
|
180/3 |
Lornoxicam/parecoxib (vs. placebo) |
+ |
ǂ drugs/ § vs. placebo |
ǂ |
Gousheh et al., 20131111 Gousheh SM, Nesioonpour S, Javaher Foroosh F, Akhondzadeh R, Sahafi SA, Alizadeh Z. Intravenous paracetamol for postoperative analgesia in laparoscopic cholecystectomy. Anesth Pain Med. 2013;3(1):214-8.
|
30/2 |
Paracetamol (vs. placebo) |
+ |
ǂ |
- |
Ureña-Frausto et al., 20131212 Ureña-Frausto CA, Plancarte-Sánchez R, Reyes-Torres JI, Ramírez-Aranda JM. Infusional therapy: an alternative for shouder pain post-laparoscopy. Cir Cir. 2013;81(3):187-95. Spanish.
|
56/4 |
Ketoprofen and tramadol (vs. ketorolac) |
+ |
§ |
ǂ |
Ekmekci et al., 20121313 Ekmekçi P, Kazak Bengisun Z, Kazbek BK, Özis SE, Tastan H, Süer AH. The efficacy of adding dexketoprofen trometamol to tramadol with patient controlled analgesia technique in post-laparoscopic cholecystectomy pain treatment. Agri. 2012;24(2):63-8.
|
40/2 |
Tramadol and dexketoprofen (vs. tramadol) |
+ |
§ |
ǂ |
NMDA receptor antagonist |
Ozhan et al., 20151414 Ozhan Y, Bakan N, Karaoren GY, Tomruk SG, Topaç Z. Effects of subanesthetic ketamine on pain and cognitive functions in TIVA. J Clin Anal Med. 2015;6(4):452-7.
|
60/2 |
Ketamine (vs. placebo) |
ǂ |
§ |
+ |
Yadav et al., 20151515 Yadav G, Behera SS, Das SK, Jain G, Choupoo S, Raj J. Role of flupirtine as a preemptive analgesic in patients undergoing laparoscopic cholecystectomy. J Anaesthesiol Clin Pharmacol. 2015;31(2):169-73.
|
66/2 |
Flupirtine (vs. placebo) |
+ |
ǂ |
+ |
Kocman et al., 20131616 Kocman IB, Krobot R, Premuzić J, Kocman I, Stare R, Katalinić L, et al. The effect of preemptive intravenous low-dose magnesium sulfate on early postoperative pain after laparoscopic cholecystectomy. Acta Clin Croat. 2013;52(3):289-94.
|
60/3 |
Magnesium sulfate (vs. placebo) |
+ |
ǂ |
ǂ |
Leal et al., 20131717 Leal PC, Sakata RK, Salomão R, Sadatsune EJ, Issy AM. Assessment of the effect of ketamine in combination with remifentanil on postoperative pain. Braz J Anesthesiol. 2013;63(2):178-82.
|
40/2 |
Ketamine (vs. placebo) |
ǂ |
ǂ |
ǂ |
Karcioglu et al., 20131818 Karcioglu M, Davarci I, Tuzcu K, Bozdogan YB, Turhanoglu S, Aydogan A, et al. Addition of ketamine to propofol-alfentanil anesthesia may reduce postoperative pain in laparoscopic cholecystectomy. Surg Laparosc Endosc Percutan Tech. 2013;23(2):197-202.
|
40/2 |
Ketamine (vs. placebo) |
+ |
§ |
+ |
Singh et al., 20131919 Singh H, Kundra S, Singh RM, Grewal A, Kaul TK, Sood D. Preemptive analgesia with Ketamine for Laparoscopic cholecystectomy. J Anaesthesiol Clin Pharmacol. 2013;29(4):478-84.
|
80/4 |
Ketamine (vs. placebo) |
+ |
§ |
+ |
Nesek-Adam et al., 20122020 Nesek-Adam V, Grizelj-Stojčić E, Mršić V, Rašić Z, Schwarz D. Preemptive use of diclofenac in combination with ketamine in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study. Surg Laparosc Endosc Percutan Tech. 2012;22(3):232-8.
|
80/2 |
Ketamine and diclofenac (vs. placebo) |
+ |
ǂ |
ǂ |
Olgun et al., 20122121 Olgun B, Oguz G, Kaya M, Savli S, Eskiçirak HE, Güney I, et al. The effects of magnesium sulphate on desflurane requirement, early recovery and postoperative analgesia in laparascopic cholecystectomy. Magnes Res. 2012;25(2):72-8.
|
60/2 |
Magnesium sulfate (vs. placebo) |
+ |
§ |
+ |
Gabapentin/Pregabalin |
Gurunathan et al., 20152222 Gurunathan U, Rapchuk IL, King G, Barnett AG, Fraser JF. The effect of pregabalin and celecoxib on the analgesic requirements after laparoscopic cholecystectomy: a randomized controlled trial. J Anesth. 2016;30(1):64-71.
|
100/4 |
Pregabalin/celecoxib/pregabalin and celecoxib (vs. placebo) |
ǂ |
ǂ |
+ |
Bekawi et al., 20142323 Bekawi MS, El Wakeel LM, Al Taher WM, Mageed WM. Clinical study evaluating pregabalin efficacy and tolerability for pain management in patients undergoing laparoscopic cholecystectomy. Clin J Pain. 2014;30(11):944-52.
|
90/3 |
Pregabalin (vs. Gabapentin or vs. placebo) |
+ |
§ |
+ |
Sarakatsianou et al., 20132424 Sarakatsianou C, Theodorou E, Georgopoulou S, Stamatiou G, Tzovaras G. Effect of pre-emptive pregabalin on pain intensity and postoperative morphine consumption after laparoscopic cholecystectomy. Surg Endosc. 2013;27(7):2504-11.
|
50/3 |
Pregabalin (vs. placebo) |
+ |
§ |
+ |
Balaban et al., 20122525 Balaban F, Yagar S, Özgök A, Koç M, Güllapoglu H. A randomized, placebo-controlled study of pregabalin for postoperative pain intensity after laparoscopic cholecystectomy. J Clin Anesth. 2012;24(3):175-8.
|
90/3 |
Pregabalin (vs. diclofenac) |
+ |
§ |
+ |
Miscellaneous |
Bakan et al., 201522 Bakan M, Umutoglu T, Topuz U, Uysal H, Bayram M, Kadioglu H, et al. Opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic cholecystectomy: a prospective, randomized, double-blinded study. Rev Bras Anestesiol. 2015;65(3):191-9. Portuguese.
|
80/2 |
Dexmedetomidine and lidocaine (vs. remifentanyl) |
+ |
ǂ |
+ |
Dereli et al., 20152626 Dereli N, Tutal ZB, Babayigit M, Kurtay A, Sahap M, Horasanli E. Effect of intraoperative esmolol infusion on anesthetic, analgesic requirements and postoperative nausea-vomitting in a group of laparoscopic cholecystectomy patients. Rev Bras Anestesiol. 2015;65(2):141-6. Portuguese.
|
60/4 |
Esmolol (vs. placebo) |
+ |
§ |
+ |
Delfino et al., 20152727 Delfino AE, de la Fuente N, Echevarría GC, Altermatt FR, Cortinez LI. Effect of acute arterial hypertension on morphine requirements and postsurgical pain. J Clin Anesth. 2015;27(3):226-32.
|
50/2 |
Phenylephrine (vs. placebo) |
ǂ |
§ |
ǂ |
Akelma et al., 20142828 Akelma FK, Ergil J, Özkan D, Akinci M, Özmen M, Gümüs J. A comparison of the effects of intraoperative esmolol and lidocaine infusions on postoperative analgesia. Anestezi Dergisi. 2014;22(1):25-31.
|
48/3 |
Esmolol/ lidocaine (vs. remifentanyl) |
+ |
§ |
ǂ |
Ortiz et al., 201433 Ortiz J, Chang LC, Tolpin DA, Minard CG, Scott BG, Rivers JM. Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy. Rev Braz Anesthesiol. 2014;64(3):145-51.
|
80/4 |
Propofol (vs. isoflurane, vs. desflurane and vs. sevoflurane) |
ǂ |
ǂ |
- |
Lee et al., 20132929 Lee JH, Kim JH, Cheong YK. The analgesic effect of nefopam with fentanyl at the end of laparoscopic cholecystectomy. Korean J Pain. 2013;26(4):361-7.
|
90/3 |
Nefopam and fentanyl (vs. fentanyl) |
+ |
ǂ |
- |
Park et al., 20123030 Park JK, Cheong SH, Lee KM, Lim SH, Lee JH, Cho K, et al. Does dexmedetomidine reduce postoperative pain after laparoscopic cholecystectomy with multimodal analgesia? Korean J Anesthesiol. 2012;63(5):436-40.
|
42/2 |
Dexmedetomidine (vs. placebo) |
+ |
ǂ |
- |
Lopez-Alvarez et al., 20123131 López-Álvarez S, Mayo-Moldes M, Zaballos M, Iglesias BG, Blanco-Dávila R. Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy: a randomized controlled trial. Can J Anaesth. 2012;59(5):442-8.
|
60/2 |
Esmolol (vs. ketamine and remifentanyl) |
+ |
§ |
ǂ |
Peripheral blockades |
Elamin et al., 20153232 Elamin G, Waters PS, Hamid H, O'Keeffe HM, Waldron RM, Duggan M, et al. Efficacy of a laparoscopically delivered transversus abdominis plane block technique during elective laparoscopic cholecystectomy: a prospective, double-blind randomized trial. J Am Coll Surg. 2015;221(2):335-44.
|
80/2 |
TAP block (vs. no blockade) |
+ |
ǂ |
ǂ |
Basaran, 20153333 Basaran B, Basaran A, Kozanhan B, Kasdogan E, Eryilmaz MA, Ozmen S. Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study. Med Sci Monit. 2015;21:1304-12.
|
76/2 |
TAP block (vs. no blockade) |
+ |
§ |
ǂ |
Pandey et al., 20153434 Pandey A, Kumar R, Kang CLS, Agarwal M. Comparative study between levobupivacaine with clonidine and ropivacaine with clonidine in thoracic epidural block for laparoscopic cholecystectomy. J Evolution Med Dent Sci. 2015;4(9):1457-65.
|
60/2 |
Epidural blockade with levobupivacaine and clonidine (vs. ropivacaine and clonidine) |
+ |
ǂ |
+ |
Bathia et al., 20143535 Bhatia N, Arora S, Jyotsna W, Kaur G. Comparison of posterior and subcostal approach to ultrasound-guided transverse abdominis plane block for postoperative analgesia in laparoscopic cholecystectomy. J Clin Anesth. 2014;26(4):294-9.
|
60/3 |
Subcostal TAP block (vs. posterior TAP block) |
+ |
§ |
ǂ |
Petersen et al., 20123636 Petersen PL, Stjernholm P, Kristiansen VB, Torup H, Hansen EG, Mitchell AU, et al. The beneficial effect of transversus abdominis plane block after laparoscopic cholecystectomy in day-case surgery: a randomized clinical trial. Anesth Analg. 2012;115(3):527-33.
|
80/2 |
TAP block with ropivacaine (vs. placebo TAP block) |
+ |
§ |
ǂ |
Opioids |
Choi et al., 20153737 Choi YJ, Park SW, Kwon HJ, Choi JM, Lee YM. Efficacy of early intravenous bolus oxycodone or fentanyl in emergence from general anaesthesia and postoperative analgesia following laparoscopic cholecystectomy: a randomized trial. J Int Med Res. 2015;43(6):809-18.
|
54/2 |
Oxycodone (vs. fentanyl) |
+ |
ǂ |
ǂ |
Hwang et al., 20143838 Hwang BY, Kwon JY, Kim E, Lee DW, Kim TK, Kim HK. Oxycodone vs. fentanyl patient-controlled analgesia after laparoscopic cholecystectomy. Int J Med Sci. 2014;11(7):658-62.
|
81/2 |
Oxycodone (vs. fentanyl) |
+ |
ǂ |
+ |