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What is the ideal working length for bridge plating osteosynthesis of a femoral shaft fracture? A multinational online survey evaluation

ABSTRACT

Objective:

to evaluate how orthopedic surgeons in Latin America define the working length for distinct patterns of femoral shaft fracture.

Methods:

a survey was developed presenting different options of working length in four femoral fracture patterns. The survey was submitted to the participants using Google Forms tool. The association between professional characteristics and medical management options according to each type of fracture was analyzed by Chi-square test, with 5% significance level.

Results:

seven hundred and seven professionals from all Latin America answered the survey. The majority prefered a smaller working length for all situations presented in the study. There was a significant association between the main interest area and the medical preference for the management in fracture types AO 32-B3 and 32-C2 (p<0.05). Other professional characteristics had no significant association at the level of 5%.

Conclusion:

most of the study participants preferred constructions with smaller working length, representing approximately one-third of the total length of the plate, regardless of fracture pattern. There was a significant association between the main interest area (orthopedic trauma) and medical management options for fracture type AO 32-B3 and 32-C2. This can be attributed in part to the fact that these two types of fractures are considered, in the view of the authors, intermediate patterns in terms of strain. This study reinforces the importance of understanding the concept of working length, showing that its calculation remains more based on the surgeons' experience than grounded by strong biomechanical concepts governing the fracture healing process.

Keywords:
Surveys and questionnaires; Bone plates; Bone screws; Femoral fractures

RESUMO

Objetivo:

avaliar a conduta de cirurgiões ortopédicos da América Latina na definição da área de trabalho em distintos padrões de fratura da diáfise do fêmur.

Métodos:

foi desenvolvido um questionário em que foram apresentadas opções de fixação extra-medular em quatro padrões de fratura da diáfise do fêmur com três diferentes áreas de trabalho. O questionário foi submetido aos participantes utilizando-se a ferramenta Googleforms. A associação entre as características profissionais e as opções de conduta médica de acordo com cada tipo de fratura foi analisada pelo teste de qui-quadrado, com nível de significância de 5%.

Resultados:

setecentos e sete profissionais da América Latina responderam o questionário. A maioria dos participantes optou por uma menor área de trabalho na osteossíntese em todas as situações do estudo. Observou-se associação significativa entre a especialidade e a conduta médica nas fraturas do tipo AO 32-B3 e 32-C2 (p < 0,05). As demais características profissionais não mostraram associação significativa.

Conclusão:

a maioria dos participantes deste estudo prefere construções com menor área de trabalho, representando aproximadamente um terço do comprimento total da placa, independentemente do padrão de fratura. Houve associação significativa entre o tipo de especialidade (trauma ortopédico) e as opções de conduta para as fraturas do tipo AO 32-B3 e 32-C. O presente estudo reforça a importância da compreensão do conceito de área de trabalho, mostrando que sua estimativa continua sendo baseada mais na experiência do cirurgião do que em conceitos biomecânicos que regem o processo de consolidação de fraturas.

Descritores:
Inquéritos e questionários; Placas ósseas; Parafusos ósseos; Fraturas do fêmur

INTRODUCTION

Fracture of femur shaft is relatively common, with a prevalence of approximately 3/10,000 people11 Giordano V, Amaral NP. Fratura da diáfise do fêmur. In: Sociedade Brasileira de ortopedia e Traumatologia. Programa de Atualização em Traumatologia e Ortopedia (PROATO). Porto Alegre: Artmed Panamericana; 2006.. Due to its high morbidity and mortality, particularly associated to high direct and indirect costs, it is a severe health public issue. Its treatment is constantly evolving, based on the higher understanding of local anatomy and biomechanical forces involved in the fixation techniques11 Giordano V, Amaral NP. Fratura da diáfise do fêmur. In: Sociedade Brasileira de ortopedia e Traumatologia. Programa de Atualização em Traumatologia e Ortopedia (PROATO). Porto Alegre: Artmed Panamericana; 2006.,22 Rozbruch SR, Müller U, Gautier E, Ganz R. The evolution of femoral shaft plating technique. Clin Orthop Relat Res. 1998;(354):195-208.. Nowadays, osteosynthesis with an intramedullary tutor, in special in blocked intramedullary shaft, is standardized for this type of fracture, with low rates of infection and pseudoarthrosis11 Giordano V, Amaral NP. Fratura da diáfise do fêmur. In: Sociedade Brasileira de ortopedia e Traumatologia. Programa de Atualização em Traumatologia e Ortopedia (PROATO). Porto Alegre: Artmed Panamericana; 2006..

However, some clinical situations, such as a very narrow medullary channel, previous vicious consolidation or the presence of implants that occupies partially the medullary channel (such as prosthesis, for example) make intramedullary osteoshyntesis unfeasible or difficult11 Giordano V, Amaral NP. Fratura da diáfise do fêmur. In: Sociedade Brasileira de ortopedia e Traumatologia. Programa de Atualização em Traumatologia e Ortopedia (PROATO). Porto Alegre: Artmed Panamericana; 2006.. In these patients, the use of extra-medullary implants is a treatment option for fracture of femur shaft, and it is necessary to determine which method must be used11 Giordano V, Amaral NP. Fratura da diáfise do fêmur. In: Sociedade Brasileira de ortopedia e Traumatologia. Programa de Atualização em Traumatologia e Ortopedia (PROATO). Porto Alegre: Artmed Panamericana; 2006.. The construction of a model with absolute stability, although allowing anatomical and direct reduction of the fracture, requires some devitalization of neighbor tissues around the bone, implying in healing problems of soft tissue and delayed consolidation11 Giordano V, Amaral NP. Fratura da diáfise do fêmur. In: Sociedade Brasileira de ortopedia e Traumatologia. Programa de Atualização em Traumatologia e Ortopedia (PROATO). Porto Alegre: Artmed Panamericana; 2006.,22 Rozbruch SR, Müller U, Gautier E, Ganz R. The evolution of femoral shaft plating technique. Clin Orthop Relat Res. 1998;(354):195-208.. For those reasons, in view of the current concepts, the use of an indirect reduction technique is advised for a more elastic stabilization of the fracture 11 Giordano V, Amaral NP. Fratura da diáfise do fêmur. In: Sociedade Brasileira de ortopedia e Traumatologia. Programa de Atualização em Traumatologia e Ortopedia (PROATO). Porto Alegre: Artmed Panamericana; 2006.

2 Rozbruch SR, Müller U, Gautier E, Ganz R. The evolution of femoral shaft plating technique. Clin Orthop Relat Res. 1998;(354):195-208.

3 Angelini AJ, Livani B, Flierl MA, Morgan SJ, Belangero WD. Less invasive percutaneous wave plating of simple femur shaft fractures: a prospective series. Injury. 2010;41(6):624-8.

4 Beltran MJ, Collinge CA, Gardner MJ. Stress modulation of fracture fixation implants. J Am Acad Orthop Surg. 2016;24(10):711-9.
-55 Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. 1979;17(138):175-96..

However, very rigid constructions are responsible for the inadequate and usually asymmetric formation of bone callus, associated or not to implant fatigue. On the other hand, elasticity of the construction plate/screws is still undefined55 Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. 1979;17(138):175-96.. At present, the length of the implant and the location and number of screws are defined by the surgeons' experience instead of biomechanics evidence55 Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. 1979;17(138):175-96.,66 Claes LE, Heigele CA. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J Biomech. 1999;32(3):255-66.. Recent guidelines using blocked implants suggest that the plate must be the longest possible and that at least three bi-cortical screws must be placed at each side of the fracture, but do not define which is the ideal working area for different patterns of femur shaft fracture55 Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. 1979;17(138):175-96.

6 Claes LE, Heigele CA. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J Biomech. 1999;32(3):255-66.

7 Chao P, Conrad BP, Lewis DD, Horodyski M, Pozzi A. Effect of plate working length on plate stiffness and cyclic fatigue life in a cadaveric femoral fracture gap model stabilized with a 12-hole 2.4 mm locking compression plate. BMC Vet Res. 2013;9:125.
-88 Huiskes D, Nunamaker R. Local stresses and bone adaption around orthopedic implants. Calcif Tissue Int. 1984;36 Suppl 1:S110-7..

In the authors experience, simple trace fractures, with high deformation percentage of the fracture site (strain) must have a working area bigger than that calculated for more complex fractures. Taking into account that hypothesis (H0), the objective of the present work was to evaluate, by a question form, the medical choice of treatment of orthopedic surgeons from different countries of Latin America to define the working area in distinct patterns of femur shaft fractures.

METHODS

It was developed a question form, divided in two parts. The first part collected information about the participant, and the second presented fixation options for four different femur shaft fractures to be selected as best choice.

Question form was developed and submitted to participants using Google Forms tool. Invitation with the link to answer the questionnaire were sent by email by the Latin America Trauma Office (AOTLat - Oficina da AO Trauma Latino-Americana). All affiliates of this medical association were invited to answer. The question form was in Spanish for all AOTLat members, except for Brazilians, who used a Portuguese version.

The first part of the question form was developed to identify professional experience grade, kind of practice and area with higher interest and action in the specialty. Since each participant was invited by email, his nationality could be identified, but this data was not used for statistical analysis.

In the second part, it was presented four fracture patterns, with illustration representing fractures classified by the AO Group as 32-A3, 32-B3, 32-C2 and 32-C3. The choice of the types of fractures was made considering those with higher trace (32-AA3 and 32-B30 and lower strain (32-C2 and32-C30), with different morphologies. In the four presented situations, the center of the fracture was always located at most central point of the femoral diaphysis. In 32-A3 fracture, it was created a fracture to simulate a 2mm diastase between proximal and distal fragments, allowing the contact of trans cortical during load. In the types 32-B3, 32-C2 and 32-C3, fracture zone was located precisely at the medium third of diaphysis. Patterns of fracture are illustrated in Figure 1, that shows the representation of fractures 32-A3, 32-B3, 32-C2 and 32-C3 of the AO classification, with one of the constructions of the answer options. In types 32-B3, 32-C2 and 32-C3 the fracture zone was located at the medium third of diaphysis.

Figure 1.
Representation of the types of fractures.

In each of these fractures, it was presented to the participants four options of answers, and three of them contained different constructions of fixation with blocked plate, with varying distribution of screws. Most proximal and most distal screws were always present and the distribution of the remaining screws was based on clinical experience and on published studies99 Märdian S, Schaser KD, Duda GN, Heyland M. Working length of locking plates determines interfragmentary movement in distal femur fractures under physiological loading. Clin Biomech (Bristol, Avon). 2015;30(4):391-6.,1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.. The represented implant corresponded to a straight LCP® (Locking Compression Plate®, DPS, USA) with 16 holes and screws numbers in a crescent fashion, from 1 to16. Although not specifically pointed out to the participants, illustrations represented blocked screws. Regardless of the type of fracture, construction options were always the same. Figures 2 and 3 show examples of the second part of que questionnaire. In each of the four presented situations, it was asked to the participant the confidence level of his answer (Figure 4).

Figure 2.
Example of one of the presented situations, representing a fracture type AO 32-A3. It must be observed that the working area diminishes from option 1 to option 3. The last option allowed participants to choose none of the presented options (questionnaire in Spanish).

Figure 3.
Example of one of the situations presented to parti cipants, representing a fracture type AO 32.C3. The working area is progressively smaller from option 1 to 3. The last option allowed the participants to choose none of the presented constructions (questionnaire in Portu guese).

Figure 4.
Confidence level of the answer (questionnaire in Portu guese).

Data were gathered according to frequency and percentage, and presented in some graphics. Association between professional characteristics (experience, kind of practice and area with higher interest in the specialty) and medical treatment options according to each type of fracture were analyzed by Chi-square test (X2). It was used a p=0.05 level of significance. Statistical analysis was processed by the statistical software SPSS version 20.0.

RESULTS

Seven hundred and seven professionals of Latin America from 15 different countries answered the questionnaire. Tables 1,2 and 3 show the frequency (n) and percentage (%) respectively, of professional characteristics and opinion regarding medical choice of treatment and respective confidence grade. In relation to professional experience, participants were divided in three categories: "less than 5 years", "5 to 10 years", and "10 or more years" and were grouped in "less than 5 years" and "5 or more years". In relation to type of professional practice, participants were divided in "academic", "non-academic", and "private practice", and posteriorly grouped as "academic" and "non-academic/private practice". In relation to area with higher interest and action in the specialty, participants were divided in "general", "orthopedics" and "trauma". Group "orthopedics" involved all participants that answered something different than General or Trauma.

Table 1
Distribution of professional characteristic of 707 participants.
Table 2
Distribution of answers in relation to medical choice of treatment
Table 3
Distribution of the confidence level in relation to corresponding medical treatment option

Distribution of medical choice options for treatment according to type of fracture is shown in Figure 5.

Figure 5.
Distribution option of medical choices of treatment according to the type of fracture (AO classification).

Each type of fracture was individually evaluated and the results will be presented in the same manner.

  • Type AO 32-A3 - there was no significant association at 5% of significance level between professional characteristics and choice of treatment for fracture AO 32-A3. Table 4 shows a descriptive analysis (frequency and percentage) of professional characteristics and treatment choice (option 1, option 2, option 3 and none) and the corresponding descriptive level (p value) of X2 test. Some grouping of professional characteristics was made, to strengthen the tendency of observed results.

Table 4
Professional characteristic and medical choice of treatment for each fracture type
  • Type AO 32-B3 - there was a significant association between area with more interest in the specialty and medical treatment choice for fracture AO 32-B3 (p=0.029 with three categories and p=0.020 with two categories). Participants more interested in trauma tended to choose "options 1, 2 and 3", while generalists (General and Orthopedics) tended to choose "none". Other professional characteristics did not show any significant association at 5% of significance level, for medical choice of treatment of fracture type AO 32-B3. Table 5 shows the descriptive analysis (frequency and percentage) of professional characteristics according to medical choice (option1, option 2, option 3, and none) and the corresponding descriptive level (p value) of x2 test. Grouping was made of professional categories to strengthen tendency of observed results.

Table 5
Professional characteristic according to medical treatment choice for fracture type AO 32-B3
  • Type AO 32-C2 - there was a significant association between major interest area in the specialty and medical choice of treatment for fracture type AO 32-C2 (p=0.034 with two categories), meaning that participants with major interest in orthopedic trauma tend to choose "options 1,2 and 3", while generalists (general and orthopedics) tend to choose "none". There is a tendency of association between major area of interest in the specialty and medical choice of treatment for fracture type AO 32-C2 (p=0.11 with three categories). Other professional categories did not present any significant association at 5% of significance level with medical choice of treatment. Table 6 shows a descriptive analysis (frequency and percentage) of professional characteristics according to medical choice of treatment (option 1, option 2, option 3 and none) and the corresponding descriptive level (p value) of X2 test. Grouping was made of professional characteristics to strength tendency of observed results.

Table 6
Professional characteristic according to medical choice of treatment for fracture type AO 32-C2
  • Type AO 32-C3 - there was a strong tendency of association between major area of interest in the specialty and medical choice of treatment for fracture type AO 32-C3 (p=0.062 with two categories). Participants with major interest in orthopedic trauma tended to choose "options 1,2 and 3), while generalists (General and Orthopedics) tend to choose "none". Probably this loss of significance, at 5% of significance level, is caused by the low number of "none" answers (n=33) for fracture type AO 32-C3. Other professional characteristics did not show any significant association at 5% of significance level, with medical choice of treatment for fracture type AO 32-C3. There was a slight tendency among specialists with more than 10 years of experience to choose the medical treatment "none", while those with less than 10 years of experience tended to choose "options 1,2 and 3" (p=0.34). Table 7 shows a descriptive analysis (frequency and percentage) of professional characteristics according to medical choice of treatment (option 1, option 2, option 3 and none) and the corresponding descriptive level (p value) of X2 test. Grouping was made of professional characteristics to strength observed results.

Table 7
Professional characteristic according to medical choice of treatment for fracture type AO 32-C3

DISCUSSION

Consolidation process of fractured bone depends directly of the biological and mechanical environment determined, respectively, by the kinetic energy that generated the lesion and by the type of stability provided by the surgeon33 Angelini AJ, Livani B, Flierl MA, Morgan SJ, Belangero WD. Less invasive percutaneous wave plating of simple femur shaft fractures: a prospective series. Injury. 2010;41(6):624-8.

4 Beltran MJ, Collinge CA, Gardner MJ. Stress modulation of fracture fixation implants. J Am Acad Orthop Surg. 2016;24(10):711-9.

5 Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. 1979;17(138):175-96.
-66 Claes LE, Heigele CA. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J Biomech. 1999;32(3):255-66.,88 Huiskes D, Nunamaker R. Local stresses and bone adaption around orthopedic implants. Calcif Tissue Int. 1984;36 Suppl 1:S110-7.. In the treatment of the femur diaphysis fracture, bridge plate is indicated when the use of intramedullary tutor is contraindicated11 Giordano V, Amaral NP. Fratura da diáfise do fêmur. In: Sociedade Brasileira de ortopedia e Traumatologia. Programa de Atualização em Traumatologia e Ortopedia (PROATO). Porto Alegre: Artmed Panamericana; 2006.. However, in the present, there is still doubt about which is the better construction for each pattern of fracture. According to the strain theory described by Perren55 Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. 1979;17(138):175-96., when stability principle is based on plate, osteosynthesis construction must present mechanical characteristics that turn it not too rigid or too flexible22 Rozbruch SR, Müller U, Gautier E, Ganz R. The evolution of femoral shaft plating technique. Clin Orthop Relat Res. 1998;(354):195-208.

3 Angelini AJ, Livani B, Flierl MA, Morgan SJ, Belangero WD. Less invasive percutaneous wave plating of simple femur shaft fractures: a prospective series. Injury. 2010;41(6):624-8.

4 Beltran MJ, Collinge CA, Gardner MJ. Stress modulation of fracture fixation implants. J Am Acad Orthop Surg. 2016;24(10):711-9.
-55 Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. 1979;17(138):175-96.. The understanding of the modulation of rigidity of the construction allows the surgeon to perform an osteosynthesis that is capable to balance biological and mechanical characteristics of each type of fracture.

Axial resistance grade and torsional stiffness of an extramedullary tutor may be modulated by the size of the working area, defined by the plate length under the fracture focus without fixation to the bone 44 Beltran MJ, Collinge CA, Gardner MJ. Stress modulation of fracture fixation implants. J Am Acad Orthop Surg. 2016;24(10):711-9.,77 Chao P, Conrad BP, Lewis DD, Horodyski M, Pozzi A. Effect of plate working length on plate stiffness and cyclic fatigue life in a cadaveric femoral fracture gap model stabilized with a 12-hole 2.4 mm locking compression plate. BMC Vet Res. 2013;9:125.,99 Märdian S, Schaser KD, Duda GN, Heyland M. Working length of locking plates determines interfragmentary movement in distal femur fractures under physiological loading. Clin Biomech (Bristol, Avon). 2015;30(4):391-6.. However, relationship of working area and interfragment mobility (strain) at the fracture focus is still undefined, making the screw positioning depended exclusively to the surgeon's experience.

In the present study, where simple trace patterns of fracture (higher strain) and complex trace (lower strain) were used, it was observed that most participants preferred a smaller working area, corresponding to one third of the plate length, regardless the pattern of the fracture. When asked about their confidence grade of the answers for the four situations, once again most participants answered that they were very confident or confident about the choice. Experience time and area with most interest of the specialty were important for the choice, in particular in some types of fractures (32-B3 e 32-C2).

In the authors opinion, different from the participants, distinct fracture patterns, involving such an antagonistic interfragment mobility as observed in fractures type AO 32-A3 e AO 32-C3 should be treated with different working areas . Ideally, in the bridge plate, interfragment mobility should be balanced under the implant and at the opposite cortical (trans), respecting the concept of stress shielding33 Angelini AJ, Livani B, Flierl MA, Morgan SJ, Belangero WD. Less invasive percutaneous wave plating of simple femur shaft fractures: a prospective series. Injury. 2010;41(6):624-8.,44 Beltran MJ, Collinge CA, Gardner MJ. Stress modulation of fracture fixation implants. J Am Acad Orthop Surg. 2016;24(10):711-9.,1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.. This is clearly observed in fractures with simpler trace, such as AO 32-A3, in the presence of a correct alignment of proximal and distal fragments. Instead, in fractures with major contact defects or severe fragmentation, as in type AO 32-C3, stress concentration is supported singly by the implant, according to the concept of stress rising. Intermediate patterns depend of other factors, such as the local of the bone wedge (type AO 32-B3) and alignment of intermediate fragment (type AO 32-C2).

When planning the working area calculation for a diaphysis fracture with simple trace, to fixate it with a bridge plate, it seems logical that the working area must be longer, allowing more flexibility of the implant. The more rigid is the construction, the higher the concentration of stress in a smaller region of the implant, increasing the risk of fatigue during the consolidation process of the fracture1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.,1111 Schell H, Epari DR, Kassi JP, Bragulla H, Bail HJ, Duda GN. The course of bone healing is influenced by the initial shear fixation stability. J Orthop Res. 2005;23(5):1022-8.. When the construction area is increased, stress concentration over the implant, particularly during flexion, is smaller, since the deformation area is bigger; also, there is a limiting factor of the bending moment consequently protecting the plate, represented by the contact to the trans cortical1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.. This observation is corroborated by several authors observations33 Angelini AJ, Livani B, Flierl MA, Morgan SJ, Belangero WD. Less invasive percutaneous wave plating of simple femur shaft fractures: a prospective series. Injury. 2010;41(6):624-8.,44 Beltran MJ, Collinge CA, Gardner MJ. Stress modulation of fracture fixation implants. J Am Acad Orthop Surg. 2016;24(10):711-9.,77 Chao P, Conrad BP, Lewis DD, Horodyski M, Pozzi A. Effect of plate working length on plate stiffness and cyclic fatigue life in a cadaveric femoral fracture gap model stabilized with a 12-hole 2.4 mm locking compression plate. BMC Vet Res. 2013;9:125.,99 Märdian S, Schaser KD, Duda GN, Heyland M. Working length of locking plates determines interfragmentary movement in distal femur fractures under physiological loading. Clin Biomech (Bristol, Avon). 2015;30(4):391-6.,1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.. By the use of an experimental model with sheep, it was demonstrated that an axial compression distance of 20% to 30% of the interval length in a 3-millimeter defect is capable to promote bone consolidation in approximately nine weeks44 Beltran MJ, Collinge CA, Gardner MJ. Stress modulation of fracture fixation implants. J Am Acad Orthop Surg. 2016;24(10):711-9.,1111 Schell H, Epari DR, Kassi JP, Bragulla H, Bail HJ, Duda GN. The course of bone healing is influenced by the initial shear fixation stability. J Orthop Res. 2005;23(5):1022-8.. In view of the known adaptive qualities of the bone, osteogenesis process is stimulated by elevated stress (or deformation), in the presence of enough stability between bone and plate55 Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. 1979;17(138):175-96..

According to the same concept, when planning the construction of the bridge plate for a multifragment fracture of femur diaphysis, working area should be the closest possible to the zone fracture1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.. Since stress concentration is observed at the fracture level, the smaller the working area is, the lower the stress over the implant (4,5,10). This fact leads to higher axial rigidity under the plate, with reduced interfragment mobility and implant deformation1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.. It has been shown that, in highly fragmented fractures, more flexible constructions predispose to inadequate formation of bone callus, potentially causing hypertrophic pseudoarthrosis or plastic deformation and mechanical failure of the implant55 Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. 1979;17(138):175-96.,1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.,1212 Linn MS, McAndrew CM, Prusaczyk B, Brimmo O, Ricci WM, Gardner MJ. Dynamic locked plating of distal femur fractures. J Orthop Trauma. 2015;29(10):447-50..

As mentioned before, intermediate patterns of fracture must be individually addressed according to the fracture concept. It must be kept in mind the need to maintain the balance between biology and mechanics, controlling variables such as reduction quality, choice of implant and rigidity grade of construction. Specifically, implant choice is important for stress modulation in the fracture focus33 Angelini AJ, Livani B, Flierl MA, Morgan SJ, Belangero WD. Less invasive percutaneous wave plating of simple femur shaft fractures: a prospective series. Injury. 2010;41(6):624-8.,44 Beltran MJ, Collinge CA, Gardner MJ. Stress modulation of fracture fixation implants. J Am Acad Orthop Surg. 2016;24(10):711-9.,1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.,1212 Linn MS, McAndrew CM, Prusaczyk B, Brimmo O, Ricci WM, Gardner MJ. Dynamic locked plating of distal femur fractures. J Orthop Trauma. 2015;29(10):447-50.. Blocked plates support higher flexion loads and torsions than conventional plates, resulting in higher stress over the implant. Due to this fact, several authors propose the use of conventional cortical screws close the fracture focus, in particular when working area is smaller, what seems to be ideal for fractures with multifragment pattern1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.,1212 Linn MS, McAndrew CM, Prusaczyk B, Brimmo O, Ricci WM, Gardner MJ. Dynamic locked plating of distal femur fractures. J Orthop Trauma. 2015;29(10):447-50.,1313 Freeman AL, Tornetta P 3rd, Schmidt A, Bechtold J, Ricci W, Fleming M. How much do locked screws add to the fixation of "hybrid" plate constructs in osteoporotic bone? J Orthop Trauma. 2010;24(3):163-9.. This technical detail reduces rigidity of the construction compared to the use of blocked screws1313 Freeman AL, Tornetta P 3rd, Schmidt A, Bechtold J, Ricci W, Fleming M. How much do locked screws add to the fixation of "hybrid" plate constructs in osteoporotic bone? J Orthop Trauma. 2010;24(3):163-9..

In the present study, although it was not the choice of most participants, the authors options for the different presented situation would be the use of a bigger working area for type AO 32-A3 ("option 1") and a smaller working area for type AO 32-C3 ("option 3"). For the other types (AO 32-B3 and 32-C2), presented at the question form, with correct axial alignment at coronal plane, we would choose an intermediate working area ("option 2"), due to the existence of some sharing grade of stress between bone and implant. It has been observed lower von Mises tension over the construction when there is bone in contact and increased working area, reducing the risk of plate failure44 Beltran MJ, Collinge CA, Gardner MJ. Stress modulation of fracture fixation implants. J Am Acad Orthop Surg. 2016;24(10):711-9.,1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9..

Our study has some limitations. One is the three distinct options of working areas, although other possibilities may exist. For this reason, each participant had the opportunity to answer that none presented option would be chosen. The choice of the assemblies used in the study tried to reproduce a model where the working area was long ("option 1"), short ("option 3"), and intermediate ("option 2"). Mardian et al (9) used similar methodology for investigation. These authors used four working areas for a quantitative analysis with finite elements using computed tomography. The definition of the position of the screws was based in their personal experience and in published recommendations99 Märdian S, Schaser KD, Duda GN, Heyland M. Working length of locking plates determines interfragmentary movement in distal femur fractures under physiological loading. Clin Biomech (Bristol, Avon). 2015;30(4):391-6.,1010 Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9..

Another limitation of the study is that the models were based in the skeleton of a young adult with excellent bone mass. The answers could have been different for older patients, and particularly with reduced bone mass. However, in these situations, other technical details of osteosynthesis seem to be more important than the definition of the working area itself1414 Bottlang M, Doornink J, Byrd GD, Fitzpatrick DC, Madey SM. A nonlocking end screw can decrease fracture risk caused by locked plating in the osteoporotic diaphysis. J Bone Joint Surg Am. 2009;91(3):620-7.,1515 Sanders R, Haidukewych GJ, Milne T, Dennis J, Latta LL. Minimal versus maximal plate fixation techniques of the ulna: the biomechanical effect of number of screws and plate length. J Orthop Trauma. 2002;16(3):166-71.. For example, if we increase the plate length, distribution of stress will occur throughout the implant, preventing concentration at the fracture level and improving the resistance of the construction1515 Sanders R, Haidukewych GJ, Milne T, Dennis J, Latta LL. Minimal versus maximal plate fixation techniques of the ulna: the biomechanical effect of number of screws and plate length. J Orthop Trauma. 2002;16(3):166-71.. In our study, the length of the implant was the longest possible among straight and non-anatomic blocked plates, according to current recommendations.

Finally, the absence of a significant association among most professional categories and the medical choice of treatment may be regarded as a study limitation. However, only in fracture type AO 32-A3 it was observed a complete association. In types AO 32-B3 and 32-C2 it was observed statistical significance at 5% with participants with higher interest in orthopedic trauma, that tended to choose more the options "1, 2, and 3". However, in type AO 32-C3, there was no statistical significance. Probably this loss of significance at a 5% level was caused by the small number of answers "none" (n=33) for this type of fracture.

We can conclude in our study that most participants (49.1%) preferred constructions with smaller working areas, representing approximately one third of total length of the plate, regardless the fracture pattern. There was a significant association between the area with more interest in the specialty (orthopedic trauma) and medical choice of treatment for fractures type AO 32-B3 and 32-C2, probably because these fractures present intermediate strain. Our study reinforces the importance of understanding the working area, but questions its concept, since its calculus is still more based on the surgeon experience than on biomechanical principles that dictate the consolidation process of the fractures.

  • Source of funding: none.

REFERÊNCIAS

  • 1
    Giordano V, Amaral NP. Fratura da diáfise do fêmur. In: Sociedade Brasileira de ortopedia e Traumatologia. Programa de Atualização em Traumatologia e Ortopedia (PROATO). Porto Alegre: Artmed Panamericana; 2006.
  • 2
    Rozbruch SR, Müller U, Gautier E, Ganz R. The evolution of femoral shaft plating technique. Clin Orthop Relat Res. 1998;(354):195-208.
  • 3
    Angelini AJ, Livani B, Flierl MA, Morgan SJ, Belangero WD. Less invasive percutaneous wave plating of simple femur shaft fractures: a prospective series. Injury. 2010;41(6):624-8.
  • 4
    Beltran MJ, Collinge CA, Gardner MJ. Stress modulation of fracture fixation implants. J Am Acad Orthop Surg. 2016;24(10):711-9.
  • 5
    Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. 1979;17(138):175-96.
  • 6
    Claes LE, Heigele CA. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J Biomech. 1999;32(3):255-66.
  • 7
    Chao P, Conrad BP, Lewis DD, Horodyski M, Pozzi A. Effect of plate working length on plate stiffness and cyclic fatigue life in a cadaveric femoral fracture gap model stabilized with a 12-hole 2.4 mm locking compression plate. BMC Vet Res. 2013;9:125.
  • 8
    Huiskes D, Nunamaker R. Local stresses and bone adaption around orthopedic implants. Calcif Tissue Int. 1984;36 Suppl 1:S110-7.
  • 9
    Märdian S, Schaser KD, Duda GN, Heyland M. Working length of locking plates determines interfragmentary movement in distal femur fractures under physiological loading. Clin Biomech (Bristol, Avon). 2015;30(4):391-6.
  • 10
    Stoffel K, Dieter U, Stachowiak G, Gächter A, Kuster MS. Biomechanical testing of the LCP--how can stability in locked internal fixators be controlled? Injury. 2003;34 Suppl 2:B11-9.
  • 11
    Schell H, Epari DR, Kassi JP, Bragulla H, Bail HJ, Duda GN. The course of bone healing is influenced by the initial shear fixation stability. J Orthop Res. 2005;23(5):1022-8.
  • 12
    Linn MS, McAndrew CM, Prusaczyk B, Brimmo O, Ricci WM, Gardner MJ. Dynamic locked plating of distal femur fractures. J Orthop Trauma. 2015;29(10):447-50.
  • 13
    Freeman AL, Tornetta P 3rd, Schmidt A, Bechtold J, Ricci W, Fleming M. How much do locked screws add to the fixation of "hybrid" plate constructs in osteoporotic bone? J Orthop Trauma. 2010;24(3):163-9.
  • 14
    Bottlang M, Doornink J, Byrd GD, Fitzpatrick DC, Madey SM. A nonlocking end screw can decrease fracture risk caused by locked plating in the osteoporotic diaphysis. J Bone Joint Surg Am. 2009;91(3):620-7.
  • 15
    Sanders R, Haidukewych GJ, Milne T, Dennis J, Latta LL. Minimal versus maximal plate fixation techniques of the ulna: the biomechanical effect of number of screws and plate length. J Orthop Trauma. 2002;16(3):166-71.

Publication Dates

  • Publication in this collection
    Jul-Aug 2017

History

  • Received
    19 Jan 2017
  • Accepted
    30 Mar 2017
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