DROGAS E NUTRIÇÃO: INTERAÇÕES E INCOMPATIBILIDADES

Shima, Hisako

doi:10.1590/0080-6234198201600300255

Resumos

A absorção de drogas pode, às vezes, ser consideravelmente alterada conforme as condições em que são ingeridas, ou seja, em jejum ou junto com alimentos ou fluidos. Além disso, alguns componentes alimentares não devem ser ingeridos com certas drogas por apresentarem efeitos adversos. O presente trabalho aborda essas interações e incompatibilidades existentes entre as drogas e os alimentos.

The use of drugs with foods or fluids can alter their absorption level. Moreover, some constituents of certain foods cannot be ingested with some drugs because they cause adverse effects. This paper presents these interactions and incompatibilities between drugs and food.

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REFERÊNCIAS BIBLIOGRÁFICAS

BATES, T. R. et alii. Effect of food on nitrofuratoin absorption. Clin. Pharmacol. Ther., Washington, 16(1) :63-8, 1974.
BOROWITZ, J. L. et alii. Mechanism of enhanced drug effects produced by dilution of the oral dose. Toxicol, appl. Pharmacol. New York, 19:164-8, 1971.
DAVIDSON, S. et alii. Human nutrition and dietetics. Edimburg, Churchill Livingstone, 1979. p. 196.
GIESBRECHT. A. M. & ZYNGIER, S. B. Absorção e distribuição de drogas. In: ZANINI, A. C. & OGA, S. Farmacologia aplicada. São Paulo, Atheneu, 1979. cap. 3, p. 27-33.
GILLESPIE, N. G. et alii. Diets affecting treatment of parkinsonism with levodopa. J. Amer. diet. Ass., Chicago, 62:525-8, 1973.
GREENBLATT, D. J. et alii. Bioavailability of digoxin tablets and elixir in the fasting and postprandial states. Clin. Pharmacol. Ther. St. Louis, 16(1):444-8, 1974.
GREENBLATT, D. J. et alii. Diazepan absorption: effect of antiacids and foods. Clin. Pharmacol. Ther., St. Louis, 24:600-9, 1978.
HATHCOCK, J. N. Nutrition: toxicology and pharmacology. Nutr. Rev., New York, 34 (3):65-70, 1976.
JEPPSON, J. & SJOGREN, J. The influence of food on side effects and absorption of lithium. Acta psychiat. scand., Kebenhavn, 51:285-8, 1975.
JOHNSON, B. F. et alii. Effect of a standart breakfast on digoxin absorption in normal subjects. Clin. Pharmacol. Ther., St. Louis, 28:315-9, 1978.
JUSKO, W. J. & LEVY, G. Absorption, metabolism and excretion of riboflavin-5' — phosphate in man. J. pharm. Sci., Washington, 56:58-62, 1967.
KABASAKALIAN, P. et alii. Parameters affecting absorption of griseofulvin in a human subject using urinary metabolite excretion data. J. pharm. Sci., Washington, 59:595-600, 1970.
KOCH-WESER, J. Biovailability of drugs. New Engl. J. Med., Boston,291(5)233-7, 1974
LAMBERT Jr, M. L. Drugs and diet interactions. Am. J. Nurs. New York, 75(3):402-6, 1975.
LEVY, G. & JUSKO, W. J. Factors affecting the absorption of riboflavin in man. J. pharm. Sci., Washington, 55:285-9, 1966.
McLEAN, A. J. et alii. Food, splanchnis blood flow and biovailability of drugs subject to first-pass metabolism. Clin. Pharmacol. Ther., St. Louis, 24:5-10, 1978.
MELANDER, A. et alii. Enhancement by food of canrenone biovailability from spironolactone. Clin. Pharmacol. Ther., St. Louis, 22(1):100-3, 1977.
MITCHELL, H. S. et alii. Nutrição. Rio de Janeiro, Interamericana, 1978. cap. 33, p. 463-6.
OGA, S. Biotransformação e excreção de drogas. In: ZANINI, A. C. & OGA, S. Farmacologia aplicada. São Paulo, Atheneu, 1979. cap. 5. p. 42-52.
PÉCOUD, A. et alii. Effect of foodstuffs on the absorption of zinc sulphate. Clin. Pharmacol. Ther., St. Louis, 17:469-74, 1975.
RESENBERG, H. A. & BATES, T. R. The influence of food on nitrofurantoin bioavailability. Clin. Pharmacol. Ther., St. Louis, 20:227-32, 1976.
ROE, D. A. Diet-drug interactions and incompatibilities. In: HATHCOCK, J. N. & COON, J. Nutrition and drug interrelations. New York, Academic Press, 1978. cap. 11, p. 319-45.
SENNELLO, L. T. et alii. Effect of food on kinetics of the nonsteroidal anti-inflamative alclofenac. Clin. Pharmacol. Ther., St. Louis, 23:414-20, 1978.
THEUER, R. C. & VÍTALE, J. J. Drug and nutrient interactions. In: SCHNEIDER, H. A. et alii. Nutritional support of medical practice. New York, Harper & Row, 1977. cap. 18, p. 297-305.
TOOTHAKER, R. D. & WELLING, P. G. The effect of food on drug biovailability. Ann. Rev. Pharmacol. Toxicol., Palo Alto, 20:173-99, 1980.
WELLING, P. G. et alii. Influence of diet and fluid on bioavailability of theophylline. Clin. Pharmacol. Ther., St. Louis, 17:475-80, 1975.
WELLING, P. G. Influence of food and diet on gastrointestinal drug absorption: a review. J. Pharmacokin. Biopharm., San Francisco, 5(4) :291-334, 1977.
WELLING, P. G. et alii. Bioavailability of erythromicin stearate: influence of food and fluid volume. J. pharm. Sci., Washington, 67(6):764-6, 1978.

Datas de Publicação

Publicação nesta coleção
Dez 1982

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

[1] BATES, T. R. et alii. Effect of food on nitrofuratoin absorption. Clin. Pharmacol. Ther., Washington, 16(1) :63-8, 1974.

[2] BOROWITZ, J. L. et alii. Mechanism of enhanced drug effects produced by dilution of the oral dose. Toxicol, appl. Pharmacol. New York, 19:164-8, 1971.

[3] DAVIDSON, S. et alii. Human nutrition and dietetics. Edimburg, Churchill Livingstone, 1979. p. 196.

[4] GIESBRECHT. A. M. & ZYNGIER, S. B. Absorção e distribuição de drogas. In: ZANINI, A. C. & OGA, S. Farmacologia aplicada. São Paulo, Atheneu, 1979. cap. 3, p. 27-33.

[5] GILLESPIE, N. G. et alii. Diets affecting treatment of parkinsonism with levodopa. J. Amer. diet. Ass., Chicago, 62:525-8, 1973.

[6] GREENBLATT, D. J. et alii. Bioavailability of digoxin tablets and elixir in the fasting and postprandial states. Clin. Pharmacol. Ther. St. Louis, 16(1):444-8, 1974.

[7] GREENBLATT, D. J. et alii. Diazepan absorption: effect of antiacids and foods. Clin. Pharmacol. Ther., St. Louis, 24:600-9, 1978.

[8] HATHCOCK, J. N. Nutrition: toxicology and pharmacology. Nutr. Rev., New York, 34 (3):65-70, 1976.

[9] JEPPSON, J. & SJOGREN, J. The influence of food on side effects and absorption of lithium. Acta psychiat. scand., Kebenhavn, 51:285-8, 1975.

[10] JOHNSON, B. F. et alii. Effect of a standart breakfast on digoxin absorption in normal subjects. Clin. Pharmacol. Ther., St. Louis, 28:315-9, 1978.

[11] JUSKO, W. J. & LEVY, G. Absorption, metabolism and excretion of riboflavin-5' — phosphate in man. J. pharm. Sci., Washington, 56:58-62, 1967.

[12] KABASAKALIAN, P. et alii. Parameters affecting absorption of griseofulvin in a human subject using urinary metabolite excretion data. J. pharm. Sci., Washington, 59:595-600, 1970.

[13] KOCH-WESER, J. Biovailability of drugs. New Engl. J. Med., Boston,291(5)233-7, 1974

[14] LAMBERT Jr, M. L. Drugs and diet interactions. Am. J. Nurs. New York, 75(3):402-6, 1975.

[15] LEVY, G. & JUSKO, W. J. Factors affecting the absorption of riboflavin in man. J. pharm. Sci., Washington, 55:285-9, 1966.

[16] McLEAN, A. J. et alii. Food, splanchnis blood flow and biovailability of drugs subject to first-pass metabolism. Clin. Pharmacol. Ther., St. Louis, 24:5-10, 1978.

[17] MELANDER, A. et alii. Enhancement by food of canrenone biovailability from spironolactone. Clin. Pharmacol. Ther., St. Louis, 22(1):100-3, 1977.

[18] MITCHELL, H. S. et alii. Nutrição. Rio de Janeiro, Interamericana, 1978. cap. 33, p. 463-6.

[19] OGA, S. Biotransformação e excreção de drogas. In: ZANINI, A. C. & OGA, S. Farmacologia aplicada. São Paulo, Atheneu, 1979. cap. 5. p. 42-52.

[20] PÉCOUD, A. et alii. Effect of foodstuffs on the absorption of zinc sulphate. Clin. Pharmacol. Ther., St. Louis, 17:469-74, 1975.

[21] RESENBERG, H. A. & BATES, T. R. The influence of food on nitrofurantoin bioavailability. Clin. Pharmacol. Ther., St. Louis, 20:227-32, 1976.

[22] ROE, D. A. Diet-drug interactions and incompatibilities. In: HATHCOCK, J. N. & COON, J. Nutrition and drug interrelations. New York, Academic Press, 1978. cap. 11, p. 319-45.

[23] SENNELLO, L. T. et alii. Effect of food on kinetics of the nonsteroidal anti-inflamative alclofenac. Clin. Pharmacol. Ther., St. Louis, 23:414-20, 1978.

[24] THEUER, R. C. & VÍTALE, J. J. Drug and nutrient interactions. In: SCHNEIDER, H. A. et alii. Nutritional support of medical practice. New York, Harper & Row, 1977. cap. 18, p. 297-305.

[25] TOOTHAKER, R. D. & WELLING, P. G. The effect of food on drug biovailability. Ann. Rev. Pharmacol. Toxicol., Palo Alto, 20:173-99, 1980.

[26] WELLING, P. G. et alii. Influence of diet and fluid on bioavailability of theophylline. Clin. Pharmacol. Ther., St. Louis, 17:475-80, 1975.

[27] WELLING, P. G. Influence of food and diet on gastrointestinal drug absorption: a review. J. Pharmacokin. Biopharm., San Francisco, 5(4) :291-334, 1977.

[28] WELLING, P. G. et alii. Bioavailability of erythromicin stearate: influence of food and fluid volume. J. pharm. Sci., Washington, 67(6):764-6, 1978.

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DROGAS E NUTRIÇÃO: INTERAÇÕES E INCOMPATIBILIDADES

Drugs and nutrition: interactions and incompatibilities

Resumos

REFERÊNCIAS BIBLIOGRÁFICAS

Datas de Publicação