Deaths and hospitalizations of victims of non-drug toxicological events in Brazil, 2009 to 2018

Duarte, Fernanda Gross; Moreira, Sandra da Silva; Barberino, Maria Goreth; Paula, Marcelo Neubauer de; Vianna, Nelzair Araújo; Almeida, Maria Conceição Chagas de; Moreira Junior, Edson Duarte

Fernanda Gross Duarte

concept and planning of the study

data collection

analysis and interpretation of the results

drafting and critically reviewing the contents of the manuscript

Instituto Gonçalo Moniz, Laboratório de Epidemiologia Molecular e Bioestatística, Salvador, BA, Brazil

http://orcid.org/0000-0001-5918-6872

Sandra da Silva Moreira

concept and planning of the study

analysis and interpretation of the results

drafting and critically reviewing the contents of the manuscript

Associação Obras Sociais Irmã Dulce, Centro de Pesquisa Clínica, Salvador, BA, Brazil

http://orcid.org/0000-0002-1988-0736

Maria Goreth Barberino

concept and planning of the study

analysis and interpretation of the results

drafting and critically reviewing the contents of the manuscript

Instituto Gonçalo Moniz, Laboratório de Epidemiologia Molecular e Bioestatística, Salvador, BA, Brazil

http://orcid.org/0000-0002-7858-0768

Marcelo Neubauer de Paula

concept and planning of the study

data collection

analysis and interpretation of the results

drafting and critically reviewing the contents of the manuscript

Grupo Hypera Pharma, São Paulo, SP, Brazil

http://orcid.org/0000-0002-6753-1733

Nelzair Araújo Vianna

concept and planning of the study

analysis and interpretation of the results

drafting and critically reviewing the contents of the manuscript

Instituto Gonçalo Moniz, Laboratório de Epidemiologia Molecular e Bioestatística, Salvador, BA, Brazil

http://orcid.org/0000-0002-5183-6671

Maria Conceição Chagas de Almeida

concept and planning of the study

data collection

analysis and interpretation of the results

drafting and critically reviewing the contents of the manuscript

Instituto Gonçalo Moniz, Laboratório de Epidemiologia Molecular e Bioestatística, Salvador, BA, Brazil

http://orcid.org/0000-0002-4760-4157

Edson Duarte Moreira Junior

concept and planning of the study

data collection

analysis and interpretation of the results

drafting and critically reviewing the contents of the manuscript

Instituto Gonçalo Moniz, Laboratório de Epidemiologia Molecular e Bioestatística, Salvador, BA, Brazil

http://orcid.org/0000-0002-7081-8348

Correspondence
Edson Duarte Moreira Junior. edson.moreira@fiocruz.br

Associate editor

Doroteia Aparecida Höfelmann - 0000-0003-1046-3319

Conflicts of interest

The authors declare that they have no conflicts of interest.

Variables	Hospitalizations		Deaths
Variables	n	%	n	%
Total	125,570	100.0	4,326	100.0
Sex
Female	47,477	37.8	1,399	32.3
Male	78,093	62.2	2,927	67.7
Age group (in years)
Under 5	10,809	8.6	53	1.2
5-9	3,575	2.8	18	0.4
10-14	4,566	3.6	66	1.5
15-19	9,789	7.8	235	5.5
20-29	21,656	17.2	632	14.6
30-39	25,364	20.2	870	20.1
40-49	23,968	19.1	972	22.5
50-59	14,884	11.9	690	16.0
60-69	6,564	5.2	430	9.9
70 or over	4,395	3.6	360	8.3
Race/skin color
White	38,684	30.8	1,204	27.8
Mixed race	37,480	29.9	1,235	28.6
Black	4,583	3.6	157	3.6
Other	1,293	1.0	51	1.2
Not informed	43,530	34.7	1679	38.8
Region
North	7,462	5.9	215	5.0
Northeast	30,555	24.3	1,382	31.9
Midwest	13,071	10.4	278	6.4
Southeast	58,017	46.2	2,070	47.9
South	16,465	13.2	381	8.8

Variables	Year										Annual Average
Variables	2009	2010	2011	2012	2013	2014	2015	2016	2017	2018	Annual Average
Hospitalization rate^a
Age group (in years)
< 5	9.1	8.7	8.9	8.5	8.4	8.2	7.8	7.5	7.3	7.1	8.1
5-9	3.0	2.8	2.8	2.8	2.4	2.5	2.2	2.1	2.0	2.0	2.5
10-14	3.2	3.0	2.9	2.9	2.8	2.7	2.7	2.3	2.7	2.7	2.8
15-19	6.5	6.4	6.3	6.1	5.9	5.5	4.7	4.4	5.1	6.1	5.7
20-29	9.9	8.8	8.0	6.8	6.5	6.2	5.6	5.1	5.1	5.4	6.7
30-39	13.7	11.8	9.9	8.7	7.8	7.4	6.6	5.5	5.3	5.2	8.2
40-49	15.2	12.8	11.4	9.8	8.8	7.7	6.8	6.0	5.7	5.1	8.9
50-59	11.3	9.3	8.4	7.2	6.3	6.4	5.5	5.0	4.7	4.2	6.8
60-69	7.2	6.1	5.5	4.5	4.7	4.1	3.9	3.5	3.1	3.0	4.6
70 or over	5.5	5.3	4.9	3.8	3.8	4.0	3.4	3.0	2.6	2.3	3.9
Total	9.4	8.3	7.5	6.6	6.2	5.8	5.2	4.7	4.6	4.5	6.3
Mortality^b
Age group (in years)
< 5	0.59	0.44	0.59	0.37	0.37	0.61	0.15	0.15	0.54	0.15	0.40
5-9	0.13	0.45	0.13	0.21	0.07	0.00	0.07	0.00	0.15	0.00	0.12
10-14	0.34	0.46	0.57	0.41	0.24	0.43	0.45	0.46	0.33	0.34	0.40
15-19	1.58	1.57	2.08	0.92	1.32	1.44	1.33	0.98	1.06	1.40	1.37
20-29	2.73	2.42	2.66	1.72	1.67	1.67	1.84	1.90	1.42	1.67	1.97
30-39	3.66	3.78	2.52	3.20	2.78	2.70	3.01	2.25	2.20	1.85	2.80
40-49	4.55	4.82	4.06	4.16	3.44	3.28	3.49	2.76	2.79	2.61	3.60
50-59	3.72	3.16	3.41	3.78	3.37	3.42	2.91	2.61	2.52	2.36	3.13
60-69	3.30	4.18	3.40	2.70	2.62	2.34	2.58	3.28	2.66	2.23	2.93
70 or over	2.23	3.65	4.47	3.89	2.32	2.98	3.93	3.08	2.57	1.99	3.11
Total	2.54	2.66	2.48	2.31	2.02	2.07	2.18	1.92	1.79	1.66	2.16

Variables	Year										Annual average	Coefficient	95%CI^a	p-value	Trend
Variables	2009	2010	2011	2012	2013	2014	2015	2016	2017	2018	Annual average	Coefficient	95%CI^a	p-value	Trend
Hospitalization^b
Region
North	5.8	5.2	5.5	5.0	5.6	4.2	3.6	3.1	2.9	3.1	4.4	-0.36	-0.47;-0.24	0.001	Falling
Midwest	13.6	9.9	10.3	9.4	9.2	8.2	7.7	6.8	6.1	6.0	8.7	-0.72	-0.92;-0.52	< 0.001	Falling
Northeast	8.0	8.8	7.5	6.1	5.2	4.9	4.3	3.7	3.6	3.4	5.6	-0.62	-0.77;-0.47	< 0.001	Falling
Southeast	10.7	8.7	8.1	7.2	6.6	6.6	5.8	5.3	5.0	4.9	6.9	-0.58	-0.72;-0.43	0.002	Falling
South	8.5	7.2	5.8	5.3	5.5	4.8	4.9	4.7	5.5	5.3	5.8	-0.29	-0.51;-0.07	0.015	Falling
Brazil	9.4	8.3	7.5	6.6	6.2	5.8	5.2	4.7	4.6	4.5	6.3	-0.54	-0.65;-0.43	< 0.001	Falling
Mortality^c
Region
North	0.99	1.79	1.70	1.08	1.36	1.16	1.15	1.41	1.17	0.82	1.26	-4.38	-11.71;2.95	0.205	Stationary
Midwest	2.96	2.86	2.81	1.96	1.27	1.84	1.49	0.83	1.07	1.55	1.86	-21.75	-32.67;-10.83	0.002	Falling
Northeast	2.81	2.95	2.55	2.62	2.52	2.49	2.51	2.51	1.82	2.24	2.50	-5.24	-12.01;1.47	0.004	Stationary
Southeast	2.94	2.98	2.78	2.69	2.15	2.35	2.60	2.04	2.30	1.72	2.46	-11.81	-17.36;-6.26	0.001	Falling
South	1.63	1.61	1.78	1.41	1.43	1.08	1.24	1.30	0.95	0.91	1.33	-8.73	-12.27;-5.20	0.003	Falling
Brazil	2.55	2.67	2.48	2.30	2.01	2.07	2.17	1.92	1.78	1.65	2.16	-10.57	-13.42;-7.72	< 0.001	Falling

[1] Correspondence
Edson Duarte Moreira Junior. edson.moreira@fiocruz.br

Brasil

Brasil

Deaths and hospitalizations of victims of non-drug toxicological events in Brazil, 2009 to 2018

Abstract

Objective:

Methods:

Results:

Conclusions: