Factores asociados a las muertes por tuberculosis en el estado de Mato Grosso, 2011-2020: estudio de cohorte retrospectivo

Lopes, Vanessa da Silva; Couto, Rodrigo de Macedo; Luz, Alexandre Peron da; Silva, Pãmela Rodrigues de Souza; Lima, Jaqueline Costa

doi:10.1590/S2237-96222024V33E20231402.EN

person Vanessa da Silva Lopes

concept and design · analysis and interpretation · drafting and reviewing · integrity

schoolUniversidade Federal de Mato Grosso, Faculdade de Enfermagem, Cuiabá, MT, Brasil

0000-0002-5702-3882

person Rodrigo de Macedo Couto

concept and design · analysis and interpretation · drafting and reviewing · integrity

schoolUniversidade Federal de São Paulo, Departamento de Medicina Preventiva, São Paulo, SP, Brasil

0000-0003-2598-5830

person Alexandre Peron da Luz

organizing and reviewing · integrity

schoolSecretaria de Estado de Saúde, Cuiabá, MT, Brasil

0009-0003-8778-6439

person Pãmela Rodrigues de Souza Silva

interpretation · drafting and reviewing · integrity

schoolUniversidade Federal de Mato Grosso, Faculdade de Enfermagem, Cuiabá, MT, Brasil

0000-0002-3602-603X

person Jaqueline Costa Lima

concept and design · analysis and interpretation · drafting and reviewing · integrity

schoolUniversidade Federal de Mato Grosso, Faculdade de Enfermagem, Cuiabá, MT, Brasil

0000-0002-2264-3301

personCorrespondence: Vanessa da Silva Lopes.
emailE-mail: vanessalopesufmt@gmail.com

groupsAUTHOR CONTRIBUTIONS

VS Lopes, RM Couto and JC Lima were responsible for the study concept and design, analysis and interpretation of the results, drafting and critically reviewing the contents of the manuscript. PRS Silva was responsible for interpreting the results, drafting and critically reviewing the manuscript. AP Luz was responsible for organizing the database and critically reviewing the manuscript. All the authors have approved the final version of the manuscript and are responsible for all aspects thereof, including the guarantee of its accuracy and integrity.

CONFLICTS OF INTEREST

The authors have no conflicts of interest to declare.

Associate editor: Thaynã Ramos Flores - http://orcid.org/0000-0003-0098-1681

Demographic, socioeconomic and housing characteristics	Total n = 12.331		Tuberculosis cases
	Total n = 12.331		Non-deaths n = 11.806		Deaths n = 525		RR (95%CI)^a	p-value
	N	%	N	%	N	%	RR (95%CI)^a	p-value
Sex^b
Female	3.895	31,6	3.773	32,0	122	23,2	1,00	< 0,001
Male	8.436	68,4	8.033	68,0	403	76,8	1,52 (1,26;1,91)	< 0,001
Age distribution (years)^b
10-17	450	3,7	444	3,8	6	1,2	1,00	< 0,001
18-39	5.389	44,2	5.281	45,2	108	20,8	1,51 (0,66;3,46)	0,327
40-59	4.081	33,5	3.893	33,4	188	36,2	3,57 (1,58;8,10)	0,002
60+	2.271	18,6	2.053	17,6	218	41,9	7,86 (3,47;17,80)	< 0,001
Race/skin color^b
White	2.553	21,2	2.442	21,1	111	21,9	1,00	< 0,001
Non-white	9.508	78,8	9.111	78,9	397	78,1	0,96 (0,77;1,19)	< 0,001
Schooling^b
Complete or incomplete higher education	788	7,9	778	8,1	10	2,7	1,00	0,134
Complete elementary education and complete high school education	3.539	35,4	3.465	36,0	74	19,9	1,66 (0,86;3,23)	< 0,001
Incomplete elementary education and incomplete high school education	4.856	48,6	4.636	48,2	220	59,1	3,69 (1,95;6,99)	< 0,001
Illiterate	808	8,1	740	7,7	68	18,3	7,15 (3,65;13,99)	< 0,001
Street dweller^b
No	6.392	97,1	6.129	97,3	263	93,6	1,00	< 0,001
Yes	189	2,9	171	2,7	18	6,4	2,45 (1,49;4,49)	< 0,001
Health professionals^b
No	6.467	98,1	6.185	98,1	282	99,6	1,00	< 0,001
Yes	124	1,9	123	1,9	1	0,4	0,18 (0,03;1,28)	< 0,001
Immigrants^b
No	6.527	99,2	6.247	99,2	280	99,3	1,00	< 0,001
Yes	50	0,8	48	0,8	2	0,7	0,93 (0,23;3,84)	< 0,001
Deprived of liberty^b
No	9.519	85,9	9.086	85,4	433	96,9	1,00	< 0,001
Yes	1.567	14,1	1.553	14,6	14	3,1	0,19 (0,11;0,323)	< 0,001

Clinical and behavioral characteristics	Total n = 12.331		Tuberculosis cases
	Total n = 12.331		Non-deaths n = 11.806		Deaths n = 525		RR (95%CI)^a	p-value
	N	%	N	%	N	%	RR (95%CI)^a	p-value
Treatment^b
Caso novo	10.725	88,4	10.289	88,5	436	85,2	1,00	< 0,001
Retratamento	1.413	11,6	1.337	11,5	76	14,8	1,34 (1,04;1,72)	< 0,001
Observed treatment^b
Not observed	1.075	22,0	1.037	22,0	38	21,3	1,00	< 0,001
Observed	3.819	78,0	3.679	78,0	140	78,7	1,04 (0,72;1,50)	< 0,001
Alcohol use^b
No	9.377	84,5	9.035	84,8	342	76,3	1,00	< 0,001
Yes	1.722	15,5	1.616	15,2	106	23,7	1,73 (1,39;2,17)	< 0,001
Drug use^b
No	6.106	89,5	5.855	89,5	251	88,7	1,00	< 0,001
Yes	719	10,5	687	10,5	32	11,3	1,09 (0,75;1,58)	< 0,001
Tobacco use^b
No	5.391	78,3	5.195	78,7	196	70,5	1,00	< 0,001
Yes	1.491	21,7	1.409	21,3	82	29,5	1,54 (1,18;2,01)	< 0,001
Diabetes^b
No	10.153	92,6	9.755	92,8	398	89,0	1,00	0,003
Yes	807	7,4	758	7,2	49	11,0	1,58 (1,17;2,15)	0,003
HIV^b
No	6.701	87,6	6.442	87,8	259	84,1	1,00	0,056
Yes	948	12,4	899	12,2	49	15,9	1,36 (0,99;1,85)	0,056
Laboratory confirmation^b
No	5.807	47,1	5.494	46,5	313	59,6	1,00	< 0,001
Yes	6.524	52,9	6.312	53,5	212	40,4	0,59 (0,49;0,70)	< 0,001

	Total n = 12.331		Non-deaths n = 11.806		Deaths n = 525		Crude RR (95%CI)^a	Adjusted RR (95%CI)^a	p-value
	N	%	N	%	N	%	Crude RR (95%CI)^a	Adjusted RR (95%CI)^a	p-value
Age group^b
10-17	450	3,7	444	3,8	6	1,2	1,00	1,00
18-39	5.389	44,2	5.281	45,2	108	20,8	1,51 (0,66;3,46)	1,43 (0,35;5,87)	0,624
40-59	4.081	33,5	3.893	33,4	188	36,2	3,57 (1,58;8,10)	2,84 (0,70;11,54)	0,145
60+	2.271	18,6	2.053	17,6	218	41,9	7,86 (3,47;17,80)	7,70 (1,91;31,04)	0,004
Schooling^b
Higher education (complete or incomplete)	788	7,9	778	8,1	10	2,7	1,00	1,00
Complete elementary education and complete high school education	3.539	35,4	3.465	36,0	74	19,9	1,66 (0,86;3,23)	2,72 (0,98;7,56)	0,054
Incomplete elementary education and incomplete high school education	4.856	48,6	4.636	48,2	220	59,1	3,69 (1,95;6,99)	3,66 (1,34;9,96)	0,011
Illiterate	808	8,1	740	7,7	68	18,3	7,15 (3,65;13,99)	4,50 (1,60;12,66)	0,054
Street dweller^b
No	6.392	97,1	6.129	97,3	263	93,6	1,00	1,00	0,003
Yes	189	2,9	171	2,7	18	6,4	2,45 (1,49;4,049)	2,41 (1,34;4,35)	0,003
Alcohol use^b
No	9.377	84,5	9.035	84,8	342	76,3	1,00	1,00	0,027
Yes	1.722	15,5	1.616	15,2	106	23,7	1,73 (1,39;2,17)	1,45 (1,04;2,02)	0,027
Laboratory confirmation^b
No	5.807	47,1	5.494	46,5	313	59,6	1,00	1,00	0,014
Yes	6.524	52,9	6.312	53,5	212	40,4	0,59 (0,49;0,70)	0,68 (0,52;0,93)	0,014
Sex^b
Female	3.895	31,6	3.773	32,0	122	23,2	1,00	1,00	0,027
Male	8.436	68,4	8.033	68,0	403	76,8	1,52 (1,26;1,91)	1,48 (1,04;2,09)	0,027
Tobacco use^b
No	5.391	78,3	5.195	78,7	196	70,5	1,00	1,00	0,259
Yes	1.491	21,7	1.409	21,3	82	29,5	1,54 (1,18;2,01)	1,32 (0,98;1,77)	0,259

[TFN1] a) RR: Relative Risk; 95%CI: 95% confidence interval; b) The difference in relation to the total number of cases (100%) corresponds to the number of cases that were unknown, left blank or filled in with data not corresponding to the tuberculosis Dictionary.

Factores asociados a las muertes por tuberculosis en el estado de Mato Grosso, 2011-2020: estudio de cohorte retrospectivo

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