Cuadro clínico para población pediátrica con SARS-CoV-2 cuidado: revisión

Martins, Lucas Amaral; Santos, Deisy Vital dos; Marques, Patrícia Figueiredo; Silva, Elaine Andrade Leal; Castro, Caroline Tianeze de; Santos, Djanilson Barbosa dos; Camargo, Climene Laura de

doi:10.1590/1983-1447.2021.20200162

person Lucas Amaral Martins

school Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Colegiado de Enfermagem. Santo Antônio de Jesus, Bahia, Brasil.school Universidade Federal da Bahia (UFBA), Escola de Enfermagem, Programa de Pós-Graduação. Salvador, Bahia, Brasil.

0000-0003-1497-6576

person Deisy Vital dos Santos

school Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Colegiado de Enfermagem. Santo Antônio de Jesus, Bahia, Brasil.

0000-0002-2312-3586

person Patrícia Figueiredo Marques

school Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Colegiado de Enfermagem. Santo Antônio de Jesus, Bahia, Brasil.

0000-0002-0242-5024

person Elaine Andrade Leal Silva

school Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Colegiado de Enfermagem. Santo Antônio de Jesus, Bahia, Brasil.school Universidade Federal da Bahia (UFBA), Escola de Enfermagem, Programa de Pós-Graduação. Salvador, Bahia, Brasil.

0000-0003-2551-1264

person Caroline Tianeze de Castro

school Universidade Federal da Bahia (UFBA), Instituto Multidisciplinar em Saúde. Vitória da Conquista, Bahia, Brasil.

0000-0002-9445-8842

person Djanilson Barbosa dos Santos

school Universidade Federal da Bahia (UFBA), Instituto Multidisciplinar em Saúde. Vitória da Conquista, Bahia, Brasil.school Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Colegiado do Bacharelado Interdisciplinar em Saúde. Santo Antônio de Jesus, Bahia, Brasil.

0000-0002-6128-1155

person Climene Laura de Camargo

school Universidade Federal da Bahia (UFBA), Instituto Multidisciplinar em Saúde. Vitória da Conquista, Bahia, Brasil.

0000-0002-4880-3916

personCorresponding author: Lucas Amaral Martins E-mail:
lucas.martins@ufrb.edu.br

Associate editor:

Dagmar Elaine Kaiser

Editor-in-chief:

Maria da Graça Oliveira Crossetti

groupsAuthorship contribution:

Lucas Amaral Martins - Conceptualization, Data curation, Formal analysis, Research, Methodology, Project administration, Software, Visualization, Writing - original draft, Writing - review and editing. Deisy Vital dos Santos - Conceptualization, Formal analysis, Research, Methodology, Project administration, Visualization, Writing - original draft, Writing - review and editing. Patrícia Figueiredo Marques - Conceptualization, Formal analysis, Research, Methodology, Project administration, Visualization, Writing - original draft, Writing - review and editing. Elaine Andrade Leal Silva - Conceptualization, Formal analysis, Research, Methodology, Visualization, Writing - original draft, Writing - review and editing. Caroline Tianeze de Castro - Conceptualization, Formal analysis, Software, Visualization, Writing - original draft, Writing - review and editing. Djanilson Barbosa dos Santos - Conceptualization, Methodology, Writing - original draft, Writing - review and editing. Climene Laura de Camargo - Conceptualization, Writing - original draft, Writing - review and editing.

The authors declare that there is no conflict of interest.

DATABASE	STRATEGY	No. of Articles 1st search 04/20/2020	No. of Articles 2nd search 05/02/2020
MEDLINE via BVS	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn” or “Infant” or “Child, Preschool”	177	370
LILACS via BVS	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn” or “Infant” or “Child, Preschool”	11	22
SCIELO	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn”	0	0
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant”	0	0
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Child, Preschool”	0	0
PubMed	“Coronavirus Infections and “Humans and “Signs and Symptoms and “Infant, Newborn	2	3
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant”	13	14
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Child, Preschool”	1	3
CINAHL	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn”	4	7
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant”	4	7
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Child, Preschool”	4	6
IBECS via BVS	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn” or “Infant” or “Child, Preschool”	2	11
EMBASE	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant”	1	1
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn”	1	1
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Child, Preschool”	0	0
Web Of Science	“Coronavirus Infections” and “Infant, Newborn”	0	0
	“Coronavirus Infections” and “Infant”	3	8
	“Coronavirus Infections” and “Child, Preschool”	0	0
	“Coronavirus Infections” and “Child”	5	7

Author	Country of study	Type of study	N	Age	Sex
Alonso Díaz et al.²⁶	Spain	Case report	1	8 days	Female
Canarutto et al.²⁵	Italy	Case report	1	32 days	Male
Feng et al.³³	China	Case series	15	4 to 14 years	Male (5) Female (10)
Kamali Aghdam et al.²⁴	Iran	Case report	1	15 days	Male
Li et al.³⁴	China	Case series	5	10 months to 6 years	Female
Li et al.³⁰	China	Case report	2	4 years	Male (1) Female (1)
Lin et al.²⁷	China	Case report	1	7 years	Female
Liu et al.³⁵	China	Case series	6	1 to 7 years	Male (2) Female (4)
Ma et al.⁴¹	China	Case series	115	51 days to 15 years	Male (73) Female (42)
Mansour et al.³¹	Lebanon	Case report	1	16 months	Female
Park et al.²⁸	South Korea	Case report	1	10 years	Female
Shi et al.³⁶	China	Case series	10	7 months to 11 years	Male (5) Female (5)
Su et al.³⁷	China	Case series	9	11 months to 9 years	Male (3) Female (6)
Sun et al.³⁹	China	Case series	8	2 months to 15 years	Male (6) Female (2)
Xia et al.⁴⁰	China	Case series	20	1 day to 14 years	Male (13) Female (7)
Xu et al.³⁸	China	Case series	10	2 months to 15 years	Male (6) Female (4)
Zeng et al.²⁹	China	Case report	1	17 days	Male
Zhang et al.³²	China	Case report	1	3 months	-

*JBI Critical Appraisal Checklist for case reports*
Study					*Q1		Q2		Q3		Q4		Q5		Q6		Q7		Q8		SCORE	Quality
Alonso Díaz et al.²⁶					*S		Y		Y		Y		Y		*N		*NA		Y		85.7%	High
Canarutto et al.²⁵					Y		N		Y		Y		N		Y		NA		Y		71.4%	High
Kamali Aghdam et al.²⁴					Y		N		Y		Y		N		Y		NA		Y		71.4%	High
Li et al.³⁰					N		N		Y		Y		N		N		NA		N		28.6%	Low
Lin et al.²⁷					Y		Y		Y		Y		Y		Y		NA		Y		100.0%	High
Mansour et al.³¹					Y		Y		Y		Y		Y		Y		NA		Y		100.0%	High
Park et al.²⁸					Y		Y		Y		Y		Y		Y		NA		Y		100.0%	High
Zeng et al.²⁹					Y		Y		Y		Y		Y		N		NA		Y		85.7%	High
Zhang et al.³²					Y		N		Y		Y		*U		N		NA		Y		57.1%	Moderate
*IHE Quality Appraisal Checklist for case series*
Study	Q 1	Q 2	Q 3	Q 4	Q 5	Q 6	Q 7	Q 8	Q 9	Q 10	Q 11	Q 12	Q 13	Q 14	Q 15	Q 16	Q 17	Q 18	Q 19	Q 20	SCORE	Quality
Feng et al.³³	Y	N	N	*P	Y	P	P	Y	N	Y	Y	Y	Y	Y	Y	Y	P	Y	Y	Y	75.0%	High
Li et al.³⁴	Y	P	N	P	Y	Y	N	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	N	Y	P	77.5%	High
Liu et al.³⁵	N	Y	Y	Y	Y	Y	N	Y	Y	Y	Y	Y	P	Y	Y	Y	Y	N	Y	Y	82.5%	High
Ma et al.⁴¹	Y	N	N	P	Y	P	P	Y	Y	Y	Y	Y	P	Y	P	Y	Y	Y	Y	N	72.5%	High
Shi et al.³⁶	Y	Y	N	Y	Y	Y	N	Y	Y	Y	Y	Y	Y	Y	Y	P	Y	N	P	Y	80.0%	High
Su et al.³⁷	Y	N	N	P	Y	Y	N	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	82.5%	High
Sun et al.³⁹	Y	P	N	P	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	90.0%	High
Xia et al.⁴⁰	Y	Y	N	P	Y	P	P	Y	Y	Y	Y	Y	P	P	P	Y	N	Y	Y	P	72.5%	High
Xu et al.³⁸	Y	P	N	P	Y	P	P	Y	Y	Y	Y	Y	Y	Y	Y	Y	N	Y	Y	Y	80.0%	High

Author	Imaging	Clinical status	Recommendations
Alonso Díaz et al.²⁶	-	Asymptomatic; Severe double pneumonia; Intermittent polypnea; Mild intercostal drainage; Self-limiting oxygen desaturations	Conducting further studies with newborns; Carrying out new collections, when the PCR of the nasopharynx is negative, if a patient has a high index of suspicion for COVID-19 virus infection
Canarutto et al.²⁵	-	Fever; Rhinitis; Cough	Maintaining a very low index of suspicion in children with symptoms, even in the absence of contact with confirmed cases of COVID-19, in all countries affected by the outbreak; The management of children affected by COVID-19 should be dictated by clinical conditions, limiting hospitalization when possible; Conducting routine chest CT in children
Feng et al.³³	Chest CT	Asymptomatic; Fever; Nasal congestion; Cough	Screening of cases of infection with epidemiological history; Adoption of RT-PCR as one of the diagnostic criteria; Using chest CT as the first choice for screening images of children with suspected COVID-19 virus infection
Kamali Aghdam et al.²⁴	Chest x-ray Echocardiogram	Fever; Lethargy; Skin spots; Difficulty breathing	Conducting PCR tests for SARS-CoV-2 in newborns with nonspecific clinical and laboratory symptoms of infection with parents with a history of COVID-19
Li et al.³⁴	Chest CT	Asymptomatic; Fever; Cough; Runny nose; Sore throat	Chest CT to assist in the diagnosis of COVID-19
Li et al.³⁰	Chest CT	Asymptomatic; Cough; Runny nose; Dyspnea	Conducting further studies on clinical manifestations in children; Performing PCR and chest CT for diagnosis, associated with child and family history and possible contact with infected individuals and clinical manifestations
Lin et al.²⁷	Chest CT	Asymptomatic	Conducting additional research with large samples to investigate the characteristics of children infected with SARS-CoV-2; Adopting an isolation period of more than 14 days for children
Liu et al.³⁵	Chest x-ray Chest CT	Fever; Cough; Vomiting.	-
Ma et al.⁴¹	Chest CT	Asymptomatic; Fever; Cough; Runny nose; Nasal congestion; Gastrointestinal symptoms; Chest tightness; Chest pain	Performing RT-PCR and chest CT in children living with positive cases of SARS-CoV-2 to verify asymptomatic infection and proceed with isolation; Continuous blood count tests that focus on alterations in white blood cells and lymphocytes; Monitoring alterations in ALT and CK-MB
Mansour et al.³¹	Chest X-ray	Fever; Lethargy; Skin spots; Difficulty breathing	-
Park et al.²⁸	-	Fever; Sputum	Closure of schools to mitigate the spread of COVID-19 in the community; Consider the possible health risks of radiation when computed tomography is needed in children
Shi et al.³⁶	-	Mild pneumonia; Upper respiratory tract infection	-
Su et al.³⁷	Chest x-ray Chest CT	Fever; Cough	-
Sun et al.³⁹	Chest X-ray	Polypnea; Fever; Cough; Sputum; Rumbling auscultation; Nausea/vomiting; Diarrhea; Fatigue/myalgia; Headache; Constipation	Early identification of the specific characteristics of severe pediatric patients and timely treatment
Xia et al.⁴⁰	Chest x-ray Echocardiogram	Fever; Cough; Diarrhea; Runny nose; Sore throat; Moist rales; Vomiting; Tachypnea; Signs of retraction; Cyanosis; Co-infection with other pathogens	Early diagnosis to improve management and clinical treatment of children; Early chest CT
Xu et al.³⁸	Chest x-ray Chest CT	Asymptomatic; Fever; Cough; Sore throat; Nasal congestion; Runny Nose; Diarrhea	-
Zeng et al.²⁹	Chest x-ray Chest CT	Fever; Diarrhea	Monitoring of anal swabs for nucleic acid test; When there is suspicion or confirmation of COVID-19 in family members or close contacts, attention should be paid to the possibility of asymptomatic and atypical infections in newborns
Zhang et al.³²	-	Fever; Sputum; Cough; Tachycardia	Carrying out PCR for feces and secretions from the nasopharynx even if the PCR for blood is negative in three alternating collections; Testing the family members; Maintaining the child and family members in isolation and follow-up

[TFN1] Source: Authors, 2020.

Cuadro clínico para población pediátrica con SARS-CoV-2 cuidado: revisión

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