Cuadro clínico para población pediátrica con SARS-CoV-2 cuidado: revisión

Martins, Lucas Amaral; Santos, Deisy Vital dos; Marques, Patrícia Figueiredo; Silva, Elaine Andrade Leal; Castro, Caroline Tianeze de; Santos, Djanilson Barbosa dos; Camargo, Climene Laura de

Lucas Amaral Martins

Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Colegiado de Enfermagem. Santo Antônio de Jesus, Bahia, Brasil.

Universidade Federal da Bahia (UFBA), Escola de Enfermagem, Programa de Pós-Graduação. Salvador, Bahia, Brasil.

http://orcid.org/0000-0003-1497-6576

Deisy Vital dos Santos

Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Colegiado de Enfermagem. Santo Antônio de Jesus, Bahia, Brasil.

http://orcid.org/0000-0002-2312-3586

Patrícia Figueiredo Marques

Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Colegiado de Enfermagem. Santo Antônio de Jesus, Bahia, Brasil.

http://orcid.org/0000-0002-0242-5024

Elaine Andrade Leal Silva

Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Colegiado de Enfermagem. Santo Antônio de Jesus, Bahia, Brasil.

Universidade Federal da Bahia (UFBA), Escola de Enfermagem, Programa de Pós-Graduação. Salvador, Bahia, Brasil.

http://orcid.org/0000-0003-2551-1264

Caroline Tianeze de Castro

Universidade Federal da Bahia (UFBA), Instituto Multidisciplinar em Saúde. Vitória da Conquista, Bahia, Brasil.

http://orcid.org/0000-0002-9445-8842

Djanilson Barbosa dos Santos

Universidade Federal da Bahia (UFBA), Instituto Multidisciplinar em Saúde. Vitória da Conquista, Bahia, Brasil.

Universidade Federal do Recôncavo da Bahia (UFRB), Centro de Ciências da Saúde, Colegiado do Bacharelado Interdisciplinar em Saúde. Santo Antônio de Jesus, Bahia, Brasil.

http://orcid.org/0000-0002-6128-1155

Climene Laura de Camargo

Universidade Federal da Bahia (UFBA), Instituto Multidisciplinar em Saúde. Vitória da Conquista, Bahia, Brasil.

http://orcid.org/0000-0002-4880-3916

Corresponding author:
Lucas Amaral Martins E-mail: lucas.martins@ufrb.edu.br

Associate editor:

Dagmar Elaine Kaiser

Editor-in-chief:

Maria da Graça Oliveira Crossetti

Authorship contribution:

Lucas Amaral Martins - Conceptualization, Data curation, Formal analysis, Research, Methodology, Project administration, Software, Visualization, Writing - original draft, Writing - review and editing. Deisy Vital dos Santos - Conceptualization, Formal analysis, Research, Methodology, Project administration, Visualization, Writing - original draft, Writing - review and editing. Patrícia Figueiredo Marques - Conceptualization, Formal analysis, Research, Methodology, Project administration, Visualization, Writing - original draft, Writing - review and editing. Elaine Andrade Leal Silva - Conceptualization, Formal analysis, Research, Methodology, Visualization, Writing - original draft, Writing - review and editing. Caroline Tianeze de Castro - Conceptualization, Formal analysis, Software, Visualization, Writing - original draft, Writing - review and editing. Djanilson Barbosa dos Santos - Conceptualization, Methodology, Writing - original draft, Writing - review and editing. Climene Laura de Camargo - Conceptualization, Writing - original draft, Writing - review and editing.

The authors declare that there is no conflict of interest.

DATABASE	STRATEGY	No. of Articles 1st search 04/20/2020	No. of Articles 2nd search 05/02/2020
MEDLINE via BVS	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn” or “Infant” or “Child, Preschool”	177	370
LILACS via BVS	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn” or “Infant” or “Child, Preschool”	11	22
SCIELO	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn”	0	0
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant”	0	0
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Child, Preschool”	0	0
PubMed	“Coronavirus Infections and “Humans and “Signs and Symptoms and “Infant, Newborn	2	3
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant”	13	14
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Child, Preschool”	1	3
CINAHL	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn”	4	7
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant”	4	7
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Child, Preschool”	4	6
IBECS via BVS	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn” or “Infant” or “Child, Preschool”	2	11
EMBASE	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant”	1	1
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Infant, Newborn”	1	1
	“Coronavirus Infections” and “Humans” and “Signs and Symptoms” and “Child, Preschool”	0	0
Web Of Science	“Coronavirus Infections” and “Infant, Newborn”	0	0
	“Coronavirus Infections” and “Infant”	3	8
	“Coronavirus Infections” and “Child, Preschool”	0	0
	“Coronavirus Infections” and “Child”	5	7

Author	Country of study	Type of study	N	Age	Sex
Alonso Díaz et al.26Alonso Díaz C, López Maestro M, Moral Pumarega MT, Flores Antón B, Pallás Alonso C. Primer caso de infección neonatal por SARS-CoV-2 en España [letter]. An Pediatr (Barc). 2020;92(4):237-8. doi: https://doi.org/10.1016/j.anpedi.2020.03.002 https://doi.org/10.1016/j.anpedi.2020.03...	Spain	Case report	1	8 days	Female
Canarutto et al.25Canarutto D, Priolo A, Russo G, Pitea M, Vigone MC, Barera G. COVID-19 infection in a paucisymptomatic infant: raising the index of suspicion in epidemic settings. Pediatr Pulmonol. 2020;55(6):E4-E5. doi: https://doi.org/10.1002/ppul.24754 https://doi.org/10.1002/ppul.24754...	Italy	Case report	1	32 days	Male
Feng et al.33Feng K, Yun Y, Wang X, Yang G, Zheng Y, Lin C, et al. [Analysis of CT features of 15 Children with 2019 novel coronavirus infection]. Zhonghua Er Ke Za Zhi. 2020;58:E007. Chinese. doi: https://doi.org/10.3760/cma.j.issn.0578-1310.2020.0007 https://doi.org/10.3760/cma.j.issn.0578-...	China	Case series	15	4 to 14 years	Male (5) Female (10)
Kamali Aghdam et al.24Kamali Aghdam M, Jafari N, Eftekhari K. Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case report. Infect Dis (Lond). 2020;52(6):427-9. doi: https://doi.org/10.1080/23744235.2020.1747634 https://doi.org/10.1080/23744235.2020.17...	Iran	Case report	1	15 days	Male
Li et al.34Li W, Cui H, Li K, Fang Y, Li S. Chest computed tomography in children with COVID-19 respiratory infection. Pediatr Radiol. 2020;50(6):796-9. doi: https://doi.org/10.1007/s00247-020-04656-7 https://doi.org/10.1007/s00247-020-04656...	China	Case series	5	10 months to 6 years	Female
Li et al.30Li Y, Guo FF, Cao Y, Li LF, Guo YJ. Insight into COVID-2019 for pediatricians. Pediatr Pulmonol. 2020;55(5):E1-E4. doi: https://doi.org/10.1002/ppul.24734 https://doi.org/10.1002/ppul.24734...	China	Case report	2	4 years	Male (1) Female (1)
Lin et al.27Lin J, Duan J, Tan T, Fu Z, Dai J. The isolation period should be longer: lesson from a child infected with SARS-CoV-2 in Chongqing, China. Pediatr Pulmonol. 2020;55(6):E6-E9. doi: https://doi.org/10.1002/ppul.24763 https://doi.org/10.1002/ppul.24763...	China	Case report	1	7 years	Female
Liu et al.35Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of Covid-19 in children in early January 2020 in Wuhan, China [correspondence]. New Engl J Med. 2020;382(14):1370-1. doi: https://doi.org/10.1056/NEJMc2003717 https://doi.org/10.1056/NEJMc2003717 ...	China	Case series	6	1 to 7 years	Male (2) Female (4)
Ma et al.41Ma Y-L, Xia S-Y, Wang M, Zhang S-M, DU W-H, Chen Q. [Clinical features of children with SARS-CoV-2 infection: an analysis of 115 cases]. Zhongguo Dang Dai Er Ke Za Zhi. 2020;22(4):290-3. doi: https://doi.org/10.7499/j.issn.1008-8830.2003016 https://doi.org/10.7499/j.issn.1008-8830...	China	Case series	115	51 days to 15 years	Male (73) Female (42)
Mansour et al.31Mansour A, Atoui R, Kanso K, Mohsen R, Fares Y, Fares J. First case of an infant with COVID-19 in the Middle East. Cureus. 2020;12(4):e7520. doi: https://doi.org/10.7759/cureus.7520 https://doi.org/10.7759/cureus.7520...	Lebanon	Case report	1	16 months	Female
Park et al.28Park JY, Han MS, Park KU, Kim JY, Choi EH. First pediatric case of coronavirus disease 2019 in Korea. J Korean Med Sci. 2020;35(11):e124. doi: https://doi.org/10.3346/jkms.2020.35.e124 https://doi.org/10.3346/jkms.2020.35.e12...	South Korea	Case report	1	10 years	Female
Shi et al.36Shi Y, Wang X, Liu G, Zhu Q, Wang J, Yu H, et al. A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China. Ann Transl Med. 2020;8(5):241. doi: https://doi.org/10.21037/atm.2020.03.22 https://doi.org/10.21037/atm.2020.03.22...	China	Case series	10	7 months to 11 years	Male (5) Female (5)
Su et al.37Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, et al. The different clinical characteristics of corona virus disease cases between children and their families in China: the character of children with COVID-19. Emerg Microbes Infect. 2020;9(1):707-13. doi: https://doi.org/10.1080/22221751.2020.1744483 https://doi.org/10.1080/22221751.2020.17...	China	Case series	9	11 months to 9 years	Male (3) Female (6)
Sun et al.39Sun D, Li H, Lu XX, Xiao H, Ren J, Zhang FR, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr. 2020;16(3):251-9. doi: https://doi.org/10.1007/s12519-020-00354-4 https://doi.org/10.1007/s12519-020-00354...	China	Case series	8	2 months to 15 years	Male (6) Female (2)
Xia et al.40Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults. Pediatr Pulmonol. 2020;55(5):1169-74. doi: https://doi.org/10.1002/ppul.24718 https://doi.org/10.1002/ppul.24718...	China	Case series	20	1 day to 14 years	Male (13) Female (7)
Xu et al.38Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502-5. doi: https://doi.org/10.1038/s41591-020-0817-4 https://doi.org/10.1038/s41591-020-0817-...	China	Case series	10	2 months to 15 years	Male (6) Female (4)
Zeng et al.29Zeng LK, Tao XW, Yuan WH, Wang J, Liu X, Liu ZS. [First case of neonate with COVID-19 in China]. Zhonghua Er Ke Za Zhi. 2020;58(4):279-80. Chinese. doi: https://doi.org/10.3760/cma.j.cn112140-20200212-00081 https://doi.org/10.3760/cma.j.cn112140-2...	China	Case report	1	17 days	Male
Zhang et al.32Zhang YH, Lin DJ, Xiao MF, Wang JC, Wei Y, Lei ZX, et al. 2019-novel coronavirus infection in a three-month-old baby. Zhonghua Er Ke Za Zhi. 2020;58(3):182-4. Chinese. doi: https://doi.org/10.3760/cma.j.issn.0578-1310.2020.03.004 https://doi.org/10.3760/cma.j.issn.0578-...	China	Case report	1	3 months	-

*JBI Critical Appraisal Checklist for case reports*
Study					*Q1		Q2		Q3		Q4		Q5		Q6		Q7		Q8		SCORE	Quality
Alonso Díaz et al.26Alonso Díaz C, López Maestro M, Moral Pumarega MT, Flores Antón B, Pallás Alonso C. Primer caso de infección neonatal por SARS-CoV-2 en España [letter]. An Pediatr (Barc). 2020;92(4):237-8. doi: https://doi.org/10.1016/j.anpedi.2020.03.002 https://doi.org/10.1016/j.anpedi.2020.03...					*S		Y		Y		Y		Y		*N		*NA		Y		85.7%	High
Canarutto et al.25Canarutto D, Priolo A, Russo G, Pitea M, Vigone MC, Barera G. COVID-19 infection in a paucisymptomatic infant: raising the index of suspicion in epidemic settings. Pediatr Pulmonol. 2020;55(6):E4-E5. doi: https://doi.org/10.1002/ppul.24754 https://doi.org/10.1002/ppul.24754...					Y		N		Y		Y		N		Y		NA		Y		71.4%	High
Kamali Aghdam et al.24Kamali Aghdam M, Jafari N, Eftekhari K. Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case report. Infect Dis (Lond). 2020;52(6):427-9. doi: https://doi.org/10.1080/23744235.2020.1747634 https://doi.org/10.1080/23744235.2020.17...					Y		N		Y		Y		N		Y		NA		Y		71.4%	High
Li et al.30Li Y, Guo FF, Cao Y, Li LF, Guo YJ. Insight into COVID-2019 for pediatricians. Pediatr Pulmonol. 2020;55(5):E1-E4. doi: https://doi.org/10.1002/ppul.24734 https://doi.org/10.1002/ppul.24734...					N		N		Y		Y		N		N		NA		N		28.6%	Low
Lin et al.27Lin J, Duan J, Tan T, Fu Z, Dai J. The isolation period should be longer: lesson from a child infected with SARS-CoV-2 in Chongqing, China. Pediatr Pulmonol. 2020;55(6):E6-E9. doi: https://doi.org/10.1002/ppul.24763 https://doi.org/10.1002/ppul.24763...					Y		Y		Y		Y		Y		Y		NA		Y		100.0%	High
Mansour et al.31Mansour A, Atoui R, Kanso K, Mohsen R, Fares Y, Fares J. First case of an infant with COVID-19 in the Middle East. Cureus. 2020;12(4):e7520. doi: https://doi.org/10.7759/cureus.7520 https://doi.org/10.7759/cureus.7520...					Y		Y		Y		Y		Y		Y		NA		Y		100.0%	High
Park et al.28Park JY, Han MS, Park KU, Kim JY, Choi EH. First pediatric case of coronavirus disease 2019 in Korea. J Korean Med Sci. 2020;35(11):e124. doi: https://doi.org/10.3346/jkms.2020.35.e124 https://doi.org/10.3346/jkms.2020.35.e12...					Y		Y		Y		Y		Y		Y		NA		Y		100.0%	High
Zeng et al.29Zeng LK, Tao XW, Yuan WH, Wang J, Liu X, Liu ZS. [First case of neonate with COVID-19 in China]. Zhonghua Er Ke Za Zhi. 2020;58(4):279-80. Chinese. doi: https://doi.org/10.3760/cma.j.cn112140-20200212-00081 https://doi.org/10.3760/cma.j.cn112140-2...					Y		Y		Y		Y		Y		N		NA		Y		85.7%	High
Zhang et al.32Zhang YH, Lin DJ, Xiao MF, Wang JC, Wei Y, Lei ZX, et al. 2019-novel coronavirus infection in a three-month-old baby. Zhonghua Er Ke Za Zhi. 2020;58(3):182-4. Chinese. doi: https://doi.org/10.3760/cma.j.issn.0578-1310.2020.03.004 https://doi.org/10.3760/cma.j.issn.0578-...					Y		N		Y		Y		*U		N		NA		Y		57.1%	Moderate
*IHE Quality Appraisal Checklist for case series*
Study	Q 1	Q 2	Q 3	Q 4	Q 5	Q 6	Q 7	Q 8	Q 9	Q 10	Q 11	Q 12	Q 13	Q 14	Q 15	Q 16	Q 17	Q 18	Q 19	Q 20	SCORE	Quality
Feng et al.33Feng K, Yun Y, Wang X, Yang G, Zheng Y, Lin C, et al. [Analysis of CT features of 15 Children with 2019 novel coronavirus infection]. Zhonghua Er Ke Za Zhi. 2020;58:E007. Chinese. doi: https://doi.org/10.3760/cma.j.issn.0578-1310.2020.0007 https://doi.org/10.3760/cma.j.issn.0578-...	Y	N	N	*P	Y	P	P	Y	N	Y	Y	Y	Y	Y	Y	Y	P	Y	Y	Y	75.0%	High
Li et al.34Li W, Cui H, Li K, Fang Y, Li S. Chest computed tomography in children with COVID-19 respiratory infection. Pediatr Radiol. 2020;50(6):796-9. doi: https://doi.org/10.1007/s00247-020-04656-7 https://doi.org/10.1007/s00247-020-04656...	Y	P	N	P	Y	Y	N	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	N	Y	P	77.5%	High
Liu et al.35Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of Covid-19 in children in early January 2020 in Wuhan, China [correspondence]. New Engl J Med. 2020;382(14):1370-1. doi: https://doi.org/10.1056/NEJMc2003717 https://doi.org/10.1056/NEJMc2003717 ...	N	Y	Y	Y	Y	Y	N	Y	Y	Y	Y	Y	P	Y	Y	Y	Y	N	Y	Y	82.5%	High
Ma et al.41Ma Y-L, Xia S-Y, Wang M, Zhang S-M, DU W-H, Chen Q. [Clinical features of children with SARS-CoV-2 infection: an analysis of 115 cases]. Zhongguo Dang Dai Er Ke Za Zhi. 2020;22(4):290-3. doi: https://doi.org/10.7499/j.issn.1008-8830.2003016 https://doi.org/10.7499/j.issn.1008-8830...	Y	N	N	P	Y	P	P	Y	Y	Y	Y	Y	P	Y	P	Y	Y	Y	Y	N	72.5%	High
Shi et al.36Shi Y, Wang X, Liu G, Zhu Q, Wang J, Yu H, et al. A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China. Ann Transl Med. 2020;8(5):241. doi: https://doi.org/10.21037/atm.2020.03.22 https://doi.org/10.21037/atm.2020.03.22...	Y	Y	N	Y	Y	Y	N	Y	Y	Y	Y	Y	Y	Y	Y	P	Y	N	P	Y	80.0%	High
Su et al.37Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, et al. The different clinical characteristics of corona virus disease cases between children and their families in China: the character of children with COVID-19. Emerg Microbes Infect. 2020;9(1):707-13. doi: https://doi.org/10.1080/22221751.2020.1744483 https://doi.org/10.1080/22221751.2020.17...	Y	N	N	P	Y	Y	N	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	82.5%	High
Sun et al.39Sun D, Li H, Lu XX, Xiao H, Ren J, Zhang FR, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr. 2020;16(3):251-9. doi: https://doi.org/10.1007/s12519-020-00354-4 https://doi.org/10.1007/s12519-020-00354...	Y	P	N	P	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	Y	90.0%	High
Xia et al.40Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults. Pediatr Pulmonol. 2020;55(5):1169-74. doi: https://doi.org/10.1002/ppul.24718 https://doi.org/10.1002/ppul.24718...	Y	Y	N	P	Y	P	P	Y	Y	Y	Y	Y	P	P	P	Y	N	Y	Y	P	72.5%	High
Xu et al.38Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502-5. doi: https://doi.org/10.1038/s41591-020-0817-4 https://doi.org/10.1038/s41591-020-0817-...	Y	P	N	P	Y	P	P	Y	Y	Y	Y	Y	Y	Y	Y	Y	N	Y	Y	Y	80.0%	High

Author	Imaging	Clinical status	Recommendations
Alonso Díaz et al.26Alonso Díaz C, López Maestro M, Moral Pumarega MT, Flores Antón B, Pallás Alonso C. Primer caso de infección neonatal por SARS-CoV-2 en España [letter]. An Pediatr (Barc). 2020;92(4):237-8. doi: https://doi.org/10.1016/j.anpedi.2020.03.002 https://doi.org/10.1016/j.anpedi.2020.03...	-	Asymptomatic; Severe double pneumonia; Intermittent polypnea; Mild intercostal drainage; Self-limiting oxygen desaturations	Conducting further studies with newborns; Carrying out new collections, when the PCR of the nasopharynx is negative, if a patient has a high index of suspicion for COVID-19 virus infection
Canarutto et al.25Canarutto D, Priolo A, Russo G, Pitea M, Vigone MC, Barera G. COVID-19 infection in a paucisymptomatic infant: raising the index of suspicion in epidemic settings. Pediatr Pulmonol. 2020;55(6):E4-E5. doi: https://doi.org/10.1002/ppul.24754 https://doi.org/10.1002/ppul.24754...	-	Fever; Rhinitis; Cough	Maintaining a very low index of suspicion in children with symptoms, even in the absence of contact with confirmed cases of COVID-19, in all countries affected by the outbreak; The management of children affected by COVID-19 should be dictated by clinical conditions, limiting hospitalization when possible; Conducting routine chest CT in children
Feng et al.33Feng K, Yun Y, Wang X, Yang G, Zheng Y, Lin C, et al. [Analysis of CT features of 15 Children with 2019 novel coronavirus infection]. Zhonghua Er Ke Za Zhi. 2020;58:E007. Chinese. doi: https://doi.org/10.3760/cma.j.issn.0578-1310.2020.0007 https://doi.org/10.3760/cma.j.issn.0578-...	Chest CT	Asymptomatic; Fever; Nasal congestion; Cough	Screening of cases of infection with epidemiological history; Adoption of RT-PCR as one of the diagnostic criteria; Using chest CT as the first choice for screening images of children with suspected COVID-19 virus infection
Kamali Aghdam et al.24Kamali Aghdam M, Jafari N, Eftekhari K. Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case report. Infect Dis (Lond). 2020;52(6):427-9. doi: https://doi.org/10.1080/23744235.2020.1747634 https://doi.org/10.1080/23744235.2020.17...	Chest x-ray Echocardiogram	Fever; Lethargy; Skin spots; Difficulty breathing	Conducting PCR tests for SARS-CoV-2 in newborns with nonspecific clinical and laboratory symptoms of infection with parents with a history of COVID-19
Li et al.34Li W, Cui H, Li K, Fang Y, Li S. Chest computed tomography in children with COVID-19 respiratory infection. Pediatr Radiol. 2020;50(6):796-9. doi: https://doi.org/10.1007/s00247-020-04656-7 https://doi.org/10.1007/s00247-020-04656...	Chest CT	Asymptomatic; Fever; Cough; Runny nose; Sore throat	Chest CT to assist in the diagnosis of COVID-19
Li et al.30Li Y, Guo FF, Cao Y, Li LF, Guo YJ. Insight into COVID-2019 for pediatricians. Pediatr Pulmonol. 2020;55(5):E1-E4. doi: https://doi.org/10.1002/ppul.24734 https://doi.org/10.1002/ppul.24734...	Chest CT	Asymptomatic; Cough; Runny nose; Dyspnea	Conducting further studies on clinical manifestations in children; Performing PCR and chest CT for diagnosis, associated with child and family history and possible contact with infected individuals and clinical manifestations
Lin et al.27Lin J, Duan J, Tan T, Fu Z, Dai J. The isolation period should be longer: lesson from a child infected with SARS-CoV-2 in Chongqing, China. Pediatr Pulmonol. 2020;55(6):E6-E9. doi: https://doi.org/10.1002/ppul.24763 https://doi.org/10.1002/ppul.24763...	Chest CT	Asymptomatic	Conducting additional research with large samples to investigate the characteristics of children infected with SARS-CoV-2; Adopting an isolation period of more than 14 days for children
Liu et al.35Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of Covid-19 in children in early January 2020 in Wuhan, China [correspondence]. New Engl J Med. 2020;382(14):1370-1. doi: https://doi.org/10.1056/NEJMc2003717 https://doi.org/10.1056/NEJMc2003717 ...	Chest x-ray Chest CT	Fever; Cough; Vomiting.	-
Ma et al.41Ma Y-L, Xia S-Y, Wang M, Zhang S-M, DU W-H, Chen Q. [Clinical features of children with SARS-CoV-2 infection: an analysis of 115 cases]. Zhongguo Dang Dai Er Ke Za Zhi. 2020;22(4):290-3. doi: https://doi.org/10.7499/j.issn.1008-8830.2003016 https://doi.org/10.7499/j.issn.1008-8830...	Chest CT	Asymptomatic; Fever; Cough; Runny nose; Nasal congestion; Gastrointestinal symptoms; Chest tightness; Chest pain	Performing RT-PCR and chest CT in children living with positive cases of SARS-CoV-2 to verify asymptomatic infection and proceed with isolation; Continuous blood count tests that focus on alterations in white blood cells and lymphocytes; Monitoring alterations in ALT and CK-MB
Mansour et al.31Mansour A, Atoui R, Kanso K, Mohsen R, Fares Y, Fares J. First case of an infant with COVID-19 in the Middle East. Cureus. 2020;12(4):e7520. doi: https://doi.org/10.7759/cureus.7520 https://doi.org/10.7759/cureus.7520...	Chest X-ray	Fever; Lethargy; Skin spots; Difficulty breathing	-
Park et al.28Park JY, Han MS, Park KU, Kim JY, Choi EH. First pediatric case of coronavirus disease 2019 in Korea. J Korean Med Sci. 2020;35(11):e124. doi: https://doi.org/10.3346/jkms.2020.35.e124 https://doi.org/10.3346/jkms.2020.35.e12...	-	Fever; Sputum	Closure of schools to mitigate the spread of COVID-19 in the community; Consider the possible health risks of radiation when computed tomography is needed in children
Shi et al.36Shi Y, Wang X, Liu G, Zhu Q, Wang J, Yu H, et al. A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China. Ann Transl Med. 2020;8(5):241. doi: https://doi.org/10.21037/atm.2020.03.22 https://doi.org/10.21037/atm.2020.03.22...	-	Mild pneumonia; Upper respiratory tract infection	-
Su et al.37Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, et al. The different clinical characteristics of corona virus disease cases between children and their families in China: the character of children with COVID-19. Emerg Microbes Infect. 2020;9(1):707-13. doi: https://doi.org/10.1080/22221751.2020.1744483 https://doi.org/10.1080/22221751.2020.17...	Chest x-ray Chest CT	Fever; Cough	-
Sun et al.39Sun D, Li H, Lu XX, Xiao H, Ren J, Zhang FR, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr. 2020;16(3):251-9. doi: https://doi.org/10.1007/s12519-020-00354-4 https://doi.org/10.1007/s12519-020-00354...	Chest X-ray	Polypnea; Fever; Cough; Sputum; Rumbling auscultation; Nausea/vomiting; Diarrhea; Fatigue/myalgia; Headache; Constipation	Early identification of the specific characteristics of severe pediatric patients and timely treatment
Xia et al.40Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults. Pediatr Pulmonol. 2020;55(5):1169-74. doi: https://doi.org/10.1002/ppul.24718 https://doi.org/10.1002/ppul.24718...	Chest x-ray Echocardiogram	Fever; Cough; Diarrhea; Runny nose; Sore throat; Moist rales; Vomiting; Tachypnea; Signs of retraction; Cyanosis; Co-infection with other pathogens	Early diagnosis to improve management and clinical treatment of children; Early chest CT
Xu et al.38Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502-5. doi: https://doi.org/10.1038/s41591-020-0817-4 https://doi.org/10.1038/s41591-020-0817-...	Chest x-ray Chest CT	Asymptomatic; Fever; Cough; Sore throat; Nasal congestion; Runny Nose; Diarrhea	-
Zeng et al.29Zeng LK, Tao XW, Yuan WH, Wang J, Liu X, Liu ZS. [First case of neonate with COVID-19 in China]. Zhonghua Er Ke Za Zhi. 2020;58(4):279-80. Chinese. doi: https://doi.org/10.3760/cma.j.cn112140-20200212-00081 https://doi.org/10.3760/cma.j.cn112140-2...	Chest x-ray Chest CT	Fever; Diarrhea	Monitoring of anal swabs for nucleic acid test; When there is suspicion or confirmation of COVID-19 in family members or close contacts, attention should be paid to the possibility of asymptomatic and atypical infections in newborns
Zhang et al.32Zhang YH, Lin DJ, Xiao MF, Wang JC, Wei Y, Lei ZX, et al. 2019-novel coronavirus infection in a three-month-old baby. Zhonghua Er Ke Za Zhi. 2020;58(3):182-4. Chinese. doi: https://doi.org/10.3760/cma.j.issn.0578-1310.2020.03.004 https://doi.org/10.3760/cma.j.issn.0578-...	-	Fever; Sputum; Cough; Tachycardia	Carrying out PCR for feces and secretions from the nasopharynx even if the PCR for blood is negative in three alternating collections; Testing the family members; Maintaining the child and family members in isolation and follow-up

[1] Corresponding author:
Lucas Amaral Martins E-mail: lucas.martins@ufrb.edu.br

Brasil

Brasil

Cuadro clínico para población pediátrica con SARS-CoV-2 cuidado: revisión

RESUMEN

Objetivo:

Método:

Resultado:

Conclusiones: