Bilateral mandibular dentigerous cysts: a case report

Cisto dentígero bilateral em mandíbula: relato de caso

Hécio Henrique Araújo de MORAIS Tasiana Guedes de Souza DIAS Ricardo José de Holanda VASCONCELLOS Belmiro Cavalcanti do Egito VASCONCELOS Auremir Rocha MELO David Alencar GONDIM Ricardo Wathson Feitosa de CARVALHO About the authors

Abstracts

Dentigerous cysts are frequently found in the maxilla. After radicular cysts, dentigerous cysts are those most commonly diagnosed, accounting for 20% of all jaw cysts. They are often asymptomatic and diagnosed incidentally during routine examinations. Clinical complications such as dental displacement, ectopic eruption, dental impaction, adjacent tooth root resorption, cortical expansion with facial asymmetry, paresthesia, pathological fracture, and even malignant transformation may occur. Despite these classical features, definitive diagnosis must always be based on histological examination. Most dentigerous cysts are solitary. The aim of this article is to report a case of bilateral mandibular dentigerous cysts in a non-syndromic patient and, through a literature review, present the available treatment modalities used successfully in this case.

Dentigerous cyst; Mandible; Odontogenic cyst


Os cistos são frequentemente encontrados nos maxilares. Depois dos cistos radiculares, os cistos dentígeros são os mais comumente diagnosticados, constituindo cerca de 20% de todos os cistos maxilo-mandibulares. Frequentemente apresentam-se de indolores, sendo achados em exames de rotina. Complicações clínicas como deslocamentos de dentes, erupções ectópicas, impacções dentárias, reabsorção das raízes dos dentes adjacentes, expansão da cortical gerando assimetria facial, parestesia e fratura patológica podem ocorrer advinda à presença dessa afecção. Apesar das características clássicas, o diagnóstico definitivo deve sempre ser baseado através do exame histopatológico. A maioria dos cistos dentígeros apresenta-se de forma solitária; múltiplos cistos são raros e geralmente são encontrados em pacientes sindrômicos. Este trabalho tem como objetivo relatar um caso de cistos dentígeros bilaterais em mandíbula no qual a descompressão teve fundamental importância para o sucesso do caso.

Cisto dentígero; Mandíbula; Cisto odontogênico


INTRODUCTION

Dentigerous cysts are common lesions of the maxillomandibular complex. They are defined as pathologic epithelium-lined cavities that surround the crown of an unerupted tooth at the level of the cementoenamel junction. Although dentigerous cysts are highly prevalent, bilateral occurrence is rare and usually associated with syndromes or systemic diseases11. Freitas DQ, Tempest LM, Sicolis E, Lopes-Neto FC. Bilateral dentigerous cysts: review of the literature and report of an unusual case. Dentomaxillofac Radiol. 2006;35(6):464-8. doi: http://dx.doi.org/10.1259/dmfr/26194891
https://doi.org/10.1259/dmfr/26194891...
, such as Maroteaux-Lamy syndrome22. Ko KS, Dover DG, Jordan RC. Bilateral dentigerous cysts--report of an unusual case and review of the literature. J Can Dent Assoc. 1999;65(1):49-51., cleidocranial dysplasia, and mucopolysaccharidosis11. Freitas DQ, Tempest LM, Sicolis E, Lopes-Neto FC. Bilateral dentigerous cysts: review of the literature and report of an unusual case. Dentomaxillofac Radiol. 2006;35(6):464-8. doi: http://dx.doi.org/10.1259/dmfr/26194891
https://doi.org/10.1259/dmfr/26194891...
.

Dentigerous cysts are usually associated with an impacted tooth, most commonly a mandibular third molar; the maxillary canine is the second most commonly affected tooth. A dentigerous cyst associated with a maxillary central incisor in an 8-year-old child has been reported in the literature33. Desai RS, Vanaki SS, Puranik RS, Tegginamani AS. Dentigerous cyst associated with permanent central incisor: a rare entity. J Indian Soc Pedod Prev Dent. 2005;23(1):49-50. doi: 10.4103/0970-4388.16030
https://doi.org/10.4103/0970-4388.16030...
. Approximately 75% of all dentigerous cysts are found in the mandible. One case of bilateral maxillary dentigerous cysts has been reported44. Ustuner E, Fitoz S, Atasoy C, Erden I, Akyar S. Bilateral maxillary dentigerous cysts: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(5):632-5. doi: 10.1067/moe.2003.123
https://doi.org/10.1067/moe.2003.123...
; the authors stressed the importance of computed tomography for better treatment planning in the reported case.

These cysts are generally asymptomatic and diagnosed incidentally on routine radiographs or during etiological investigation of an unerupted tooth11. Freitas DQ, Tempest LM, Sicolis E, Lopes-Neto FC. Bilateral dentigerous cysts: review of the literature and report of an unusual case. Dentomaxillofac Radiol. 2006;35(6):464-8. doi: http://dx.doi.org/10.1259/dmfr/26194891
https://doi.org/10.1259/dmfr/26194891...
. Signs and symptoms arise when the cyst expands enough to cause pain and bone expansion55. Aziz SR, Pulse C, Dourmas MA, Roser SM. Inferior alveolar nerve paresthesia associated with a mandibular dentigerous cyst. J Oral Maxillofac Surg. 2002;60(4):457-9. doi: 10.1053/joms.2002.31238
https://doi.org/10.1053/joms.2002.31238...
. Although clinical complaints are valuable, histological examination is essential for definitive diagnosis11. Freitas DQ, Tempest LM, Sicolis E, Lopes-Neto FC. Bilateral dentigerous cysts: review of the literature and report of an unusual case. Dentomaxillofac Radiol. 2006;35(6):464-8. doi: http://dx.doi.org/10.1259/dmfr/26194891
https://doi.org/10.1259/dmfr/26194891...
.

Histologically, dentigerous cysts may be inflamed or uninflamed. When uninflamed, they are characterized by a wall of relatively loose connective tissue, and an epithelial lining consisting of two to four layers of cuboidal cells. When inflamed, the fibrous wall is more collagenized, with a chronic inflammatory infiltrate. The epithelial lining is hyperplastic, and a keratinized surface is sometimes observed.

The exact histogenesis of dentigerous cysts is still unknown, but most authors agree they are of developmental origin.

It has been suggested that two types of dentigerous cysts exist66. Benn A, Altini M. Dentigerous cysts of inflammatory origin: a clinicopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81(2):203-9. doi: 10.1016/S1079-2104(96)80416-1
https://doi.org/10.1016/S1079-2104(96)80...
. The first are developmental cysts of the permanent dentition, and are usually the result of an impacted tooth. These cysts occur in the second or third decade of life and are discovered on routine radiographs. The second type are inflammatory cysts that occur in immature teeth, as a result of periapical inflammation, generally due to a nonvital deciduous tooth or to dissemination of an inflammatory process affecting the follicle of a permanent tooth. These cysts are diagnosed in the first or second decade of life. It has also been suggested that concomitant use of ciclosporin and calcium channel blockers may have an influence on the formation of maxillary cysts. These drugs may alter mechanisms that regulate gingival stromal tissue reabsorption, thus causing gingival hypertrophy, which may obstruct tooth eruption and, consequently, facilitate cyst development77. De Biase A, Ottolenghi L, Polimeni A, Benvenuto A, Lubrano R, Magliocca FM. Bilateral mandibular cysts associated with cyclosporine use: a case report. Pediatr Nephrol. 2001;16(12):993-5..

The role of the p53 protein in the development of odontogenic cysts through alterations in cell proliferation was studied by Piattelli et al.88. Piattelli A, Fioroni M, Santinelli A, Rubini C. P53 protein expression in odontogenic cysts. J Endod 2001;27(7):459-61., who found that p53-positive tissues appear to exhibit greater proliferative activity; of the 24 cases of dentigerous cysts studied, 9.1% were positive for this protein.

On radiography, a dentigerous cyst should be suspected if the follicular space is larger than 5 mm2. The lesion appears as a radiolucent, unilocular area, with well-defined sclerotic borders, associated with the crown of an unerupted tooth. Cortical expansion and root resorption are often observed11. Freitas DQ, Tempest LM, Sicolis E, Lopes-Neto FC. Bilateral dentigerous cysts: review of the literature and report of an unusual case. Dentomaxillofac Radiol. 2006;35(6):464-8. doi: http://dx.doi.org/10.1259/dmfr/26194891
https://doi.org/10.1259/dmfr/26194891...
, but other lesions have also been reported. Lung et al.99. Lung K, Ganatra S, Robinson CE, Dobrovolsky W, Peters E. Multiple multilocular dentigerous cysts with intra-osseous and extra-osseous third molar displacement: a case report [cited 2012 Ago 10]. Available from: <http://www.oralhealthgroup.com/news/multiple-multilocular-dentigerous-cysts-with-intra-osseous-and-extra-osseous-third-molar-displacemen/1000204906/>.
http://www.oralhealthgroup.com/news/mult...
reported a case of intra- and extraosseous dental displacement, with migration of the tooth into the submandibular soft tissues.

Clinically, the differential diagnosis of dentigerous cyst must include other cystic lesions, such as keratocyst and primordial cyst, and odontogenic tumors such as mural ameloblastoma, unilocular ameloblastoma, ameloblastic fibroma, and adenomatoid odontogenic tumor55. Aziz SR, Pulse C, Dourmas MA, Roser SM. Inferior alveolar nerve paresthesia associated with a mandibular dentigerous cyst. J Oral Maxillofac Surg. 2002;60(4):457-9. doi: 10.1053/joms.2002.31238
https://doi.org/10.1053/joms.2002.31238...
,1010. Martinez-Perez D, Varela-Morales M. Conservative treatment of dentigerous cysts in children: a report of 4 cases. J Oral Maxillofac Surg. 2001;59(3):331-3. doi: 10.1053/joms.2001.21006
https://doi.org/10.1053/joms.2001.21006...
. Even more severe entities, such as glandular odontogenic cyst1111. Kasaboglu O, Basal Z, Usubutun A. Glandular odontogenic cyst presenting as a dentigerous cyst: a case report. J Oral Maxillofac Surg. 2006;64(4):731-3. or even squamous cell carcinoma, the management of which differs substantially from that of dentigerous cysts, should be considered in the differential diagnosis of these lesions1212. Yasuoka T, Yonemoto K, Kato Y, Tatematsu N. Squamous cell carcinoma arising in a dentigerous cyst. J Oral Maxillofac Surg. 2000;58(8):900-5. doi: 10.1053/joms.2000.8219
https://doi.org/10.1053/joms.2000.8219...
-1313. Gulbranson SH, Wolfrey JD, Raines JM, Mcnally BP. Squamous cell carcinoma arising in a dentigerous cyst in a 16-month-old girl. Otolaryngol Head Neck Surg. 2002;127(5):463-4. doi: 10.1067/mhn.2002.129039
https://doi.org/10.1067/mhn.2002.129039...
.

In a study of 327 patients with head and neck infections requiring hospitalization1414. Smith JL 2(nd); Kellman RM. Dentigerous cysts presenting as head and neck infections. Otolaryngol Head Neck Surg. 2005;133(5):715-7. doi: 10.1016/j.otohns.2005.07.014
https://doi.org/10.1016/j.otohns.2005.07...
, the underlying etiology was a dentigerous cyst in 7 cases.

The usual treatment is judicious enucleation of the cyst and removal of the impacted or unerupted tooth. If eruption of the involved teeth is viable, enucleation alone may be performed. Large cysts may be marsupialized instead to facilitate decompression, and enucleated later through a more conservative surgical procedure. If complete excision is achieved, the prognosis is excellent and recurrence is rare55. Aziz SR, Pulse C, Dourmas MA, Roser SM. Inferior alveolar nerve paresthesia associated with a mandibular dentigerous cyst. J Oral Maxillofac Surg. 2002;60(4):457-9. doi: 10.1053/joms.2002.31238
https://doi.org/10.1053/joms.2002.31238...
.

Ertas & Yavuz1515. Ertas U, Yavuz MS. Interesting eruption of 4 teeth associated with a large dentigerous cyst in mandible by only marsupialization. J Oral Maxillofac Surg 2003;61(6):728-30. doi: 10.1053/joms.2003.50145
https://doi.org/10.1053/joms.2003.50145...
reported a case in which four extremely displaced teeth associated with an extensive dentigerous cyst in a 9-year-old erupted after marsupialization alone, with no need for postoperative orthodontic treatment. The authors believe that eruption is dependent on patient age and incomplete root formation.

Marsupialization is advocated as a treatment option for dentigerous cysts, particularly in children1010. Martinez-Perez D, Varela-Morales M. Conservative treatment of dentigerous cysts in children: a report of 4 cases. J Oral Maxillofac Surg. 2001;59(3):331-3. doi: 10.1053/joms.2001.21006
https://doi.org/10.1053/joms.2001.21006...
.

The proposed treatment for cysts considered to be of inflammatory origin is extraction of the nonvital deciduous tooth and marsupialization of the lesion to enable eruption of the permanent tooth66. Benn A, Altini M. Dentigerous cysts of inflammatory origin: a clinicopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81(2):203-9. doi: 10.1016/S1079-2104(96)80416-1
https://doi.org/10.1016/S1079-2104(96)80...
.

CASE REPORT

A 15-year-old white male presented to the Department of Oral Surgery of the Universidade de Pernambuco School of Dentistry (FOP/UPE) with a chief complaint of enlargement of the right retromolar region of 6 months' duration. The patient denied any parafunctional habits, smoking, alcohol intake, or systemic changes. Extraoral examination revealed facial asymmetry with marked enlargement in the region of the right mandibular body, which was firm and tender to palpation. Intraoral examination showed a firm, tender area of enlargement of the buccal cortical plate of the mandible, with no mucosal discoloration; teeth #37, #38, #47, and #48 were absent. Radiographs showed unilocular, well-circumscribed radiolucent areas involving the crowns of the mandibular second molars, which were retained due to mechanical restrictions caused by horizontally impacted third molars ( Figure 1). History, physical examination, and imaging did not provide any evidence of syndromic or systemic involvement.

Figure 1.
Orthopanthomogram showing radiolucent areas involving the mandibular second molars and the mandibular third molars involved in impaction.

Based on the clinical and radiographic characteristic, a tentative diagnosis of dentigerous cyst was established for both lesions. Prior to definitive treatment, bilateral needle aspiration (yielding straw-colored fluid) and incisional biopsies were performed. The surgical specimens were sent to the FOP/UPE Department of Oral Pathology for analysis. Histological examination revealed an uninflamed connective tissue capsule, with remnants of odontogenic epithelium, and three to four layers of cuboidal cells in the epithelium of the cyst. Both lesions received a final histopathological diagnosis of dentigerous cyst.

The right-sided cyst was decompressed by placing a plastic device during extraction of the impacted third molar. The device was kept in place for 2 months, and the patient was instructed to perform daily irrigation with 0.9% saline solution through the device and adhere to excellent oral hygiene practices. The cyst was removed completely at a later stage ( Figure 2), after its dimensions had been reduced by decompression.

Figure 2.
Plastic device placed in the buccal sulcus and sutured so as to enable cyst decompression.

The left-sided cyst was enucleated during extraction of the third molar ( Figure 3).

Figure 3.
Appearance of the surgical cavity after enucleation of the cyst, extraction of tooth #38, and preservation of tooth #37.

At 7-month follow-up, radiographic examination showed eruption of tooth #47, to the occlusal plane, as well as bone neoformation in the area previously visualized as a large radiolucency in the region of teeth #47 and #48; on the left side, tooth #37 had erupted and there was visible bone neoformation in the region of #37 and #38 ( Figure 4), thus demonstrating the absence of recurrence.

Figure 4.
Orthopantomogram showing tooth #47 on the occlusal plane and bilateral bone neoformation in the affected areas.

DISCUSSION

Bilateral occurrence of dentigerous cysts in nonsyndromic patients is a rare condition99. Lung K, Ganatra S, Robinson CE, Dobrovolsky W, Peters E. Multiple multilocular dentigerous cysts with intra-osseous and extra-osseous third molar displacement: a case report [cited 2012 Ago 10]. Available from: <http://www.oralhealthgroup.com/news/multiple-multilocular-dentigerous-cysts-with-intra-osseous-and-extra-osseous-third-molar-displacemen/1000204906/>.
http://www.oralhealthgroup.com/news/mult...
. Only 17 cases of bilateral dentigerous cyst in the absence of a syndrome or systemic disease have been reported.

Dentigerous cysts are typically asymptomatic11. Freitas DQ, Tempest LM, Sicolis E, Lopes-Neto FC. Bilateral dentigerous cysts: review of the literature and report of an unusual case. Dentomaxillofac Radiol. 2006;35(6):464-8. doi: http://dx.doi.org/10.1259/dmfr/26194891
https://doi.org/10.1259/dmfr/26194891...
, but clinical complications such as development of inferior alveolar nerve paresthesia arouse suspicion of more serious conditions, such as malignancies, direct or indirect neurovascular injury, or systemic diseases such as diabetes or multiple sclerosis. One case of paresthesia in a patient with a mandibular dentigerous cyst was resolved after excision55. Aziz SR, Pulse C, Dourmas MA, Roser SM. Inferior alveolar nerve paresthesia associated with a mandibular dentigerous cyst. J Oral Maxillofac Surg. 2002;60(4):457-9. doi: 10.1053/joms.2002.31238
https://doi.org/10.1053/joms.2002.31238...
. In the present case, the patient's only complaint was enlargement and tenderness of the affected area.

The differential diagnosis of dentigerous cyst must include lesions such as keratocyst and primordial cyst and odontogenic tumors such as mural ameloblastoma, unilocular ameloblastoma, ameloblastic fibroma, and adenomatoid odontogenic tumor55. Aziz SR, Pulse C, Dourmas MA, Roser SM. Inferior alveolar nerve paresthesia associated with a mandibular dentigerous cyst. J Oral Maxillofac Surg. 2002;60(4):457-9. doi: 10.1053/joms.2002.31238
https://doi.org/10.1053/joms.2002.31238...
,1010. Martinez-Perez D, Varela-Morales M. Conservative treatment of dentigerous cysts in children: a report of 4 cases. J Oral Maxillofac Surg. 2001;59(3):331-3. doi: 10.1053/joms.2001.21006
https://doi.org/10.1053/joms.2001.21006...
. Bilateral dentigerous cysts should raise suspicion of a syndrome or systemic condition11. Freitas DQ, Tempest LM, Sicolis E, Lopes-Neto FC. Bilateral dentigerous cysts: review of the literature and report of an unusual case. Dentomaxillofac Radiol. 2006;35(6):464-8. doi: http://dx.doi.org/10.1259/dmfr/26194891
https://doi.org/10.1259/dmfr/26194891...
. Neither was found in the present case, which is exceedingly rare.

Treatment of dentigerous cysts generally consists of enucleation. However, cysts that cause major dental displacement and involve major bone loss must be decompressed. This treatment modality encourages new bone formation, as marsupialization decreases pressure within the cyst. The main disadvantage of marsupialization is that pathological tissue remains in situ and is not examined histologically. The cyst tissue removed with the bony window can be sent for anatomic pathology examination, but a more aggressive lesion may be present in residual tissue1616. Peterson LJ, Edward E, Hupp JR, Myron RT. Cirurgia oral e maxilofacial contemporânea. 2ª ed. Rio de Janeiro: Guanabara Koogan; 2000..

In the case described herein, marsupialization of the right mandibular angle lesion was justified by the risk of fracture with single-stage enucleation. At the left mandibular angle, where the lesion was smaller, the decision to perform single-stage enucleation proved safe and appropriate. As the horizontal position of the mandibular third molars was the true cause of impaction of teeth #37 and #47, the decision was made to extract the third molars and conduct rigorous follow-up of eruption of the second molars.

In the vast majority of cases, dentigerous cysts can be treated via an intraoral approach, as in this report. There are two reports in the literature of enucleation of dentigerous cysts and extraction of the associated tooth via the extraoral (Risdon) approach described by Ellis & Zide1717. Ellis E, Zide MF. Surgical aprroaches to the facial skeleton. 2 ed. Baltimore: Williams & Wilkins; 2006.,1818. Mintz S, Allard M, Nour R. Extraoral removal of mandibular odontogenic dentigerous cysts: a report of 2 cases. J Oral Maxillofac Surg. 2001;59(9):1094-6. doi: 10.1053/joms.2001.25857
https://doi.org/10.1053/joms.2001.25857...
. In both cases, the inferior border of the mandible was substantially weakened and the authors decided to use internal fixation to provide reinforcement and prevent mandibular fractures.

Some authors1919. Chew YS, Aghabeigi B. Spontaneous regression of bilateral dentigerous cysts: a case report. Dent Update. 2008;35(1):63-5.-2020. Shah N, Thuau H, Beale I. Spontaneous regression of bilateral dentigerous cysts associated with impacted mandibular third molars. Br Dent J. 2002;192(2):75-6. doi:10.1038/sj.bdj.4801297
https://doi.org/10.1038/sj.bdj.4801297...
have reported that surgery is not the only treatment modality for dentigerous cyst. Two rare cases of bilateral dentigerous cysts treated with a conservative approach have been reported; both progressed to spontaneous resolution, preventing an unnecessary surgical procedure1919. Chew YS, Aghabeigi B. Spontaneous regression of bilateral dentigerous cysts: a case report. Dent Update. 2008;35(1):63-5.. However, the mechanism involved in spontaneous regression is still unknown. It is believed that rupture of the cyst wall creates an opening into the oral cavity, decompressing the lesion in a manner similar to marsupialization2020. Shah N, Thuau H, Beale I. Spontaneous regression of bilateral dentigerous cysts associated with impacted mandibular third molars. Br Dent J. 2002;192(2):75-6. doi:10.1038/sj.bdj.4801297
https://doi.org/10.1038/sj.bdj.4801297...
.

CONCLUSION

This report presented two treatment modalities used to address the same pathological condition. This combination was justified by the discrepancy in size of the two lesions, and enabled successful treatment of both.

When dentigerous cysts are present bilaterally, the patient should be investigated for syndromes or systemic disease, as this presentation is exceedingly rare in nonsyndromic settings.

REFERENCES

  • 1
    Freitas DQ, Tempest LM, Sicolis E, Lopes-Neto FC. Bilateral dentigerous cysts: review of the literature and report of an unusual case. Dentomaxillofac Radiol. 2006;35(6):464-8. doi: http://dx.doi.org/10.1259/dmfr/26194891
    » https://doi.org/10.1259/dmfr/26194891
  • 2
    Ko KS, Dover DG, Jordan RC. Bilateral dentigerous cysts--report of an unusual case and review of the literature. J Can Dent Assoc. 1999;65(1):49-51.
  • 3
    Desai RS, Vanaki SS, Puranik RS, Tegginamani AS. Dentigerous cyst associated with permanent central incisor: a rare entity. J Indian Soc Pedod Prev Dent. 2005;23(1):49-50. doi: 10.4103/0970-4388.16030
    » https://doi.org/10.4103/0970-4388.16030
  • 4
    Ustuner E, Fitoz S, Atasoy C, Erden I, Akyar S. Bilateral maxillary dentigerous cysts: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(5):632-5. doi: 10.1067/moe.2003.123
    » https://doi.org/10.1067/moe.2003.123
  • 5
    Aziz SR, Pulse C, Dourmas MA, Roser SM. Inferior alveolar nerve paresthesia associated with a mandibular dentigerous cyst. J Oral Maxillofac Surg. 2002;60(4):457-9. doi: 10.1053/joms.2002.31238
    » https://doi.org/10.1053/joms.2002.31238
  • 6
    Benn A, Altini M. Dentigerous cysts of inflammatory origin: a clinicopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81(2):203-9. doi: 10.1016/S1079-2104(96)80416-1
    » https://doi.org/10.1016/S1079-2104(96)80416-1
  • 7
    De Biase A, Ottolenghi L, Polimeni A, Benvenuto A, Lubrano R, Magliocca FM. Bilateral mandibular cysts associated with cyclosporine use: a case report. Pediatr Nephrol. 2001;16(12):993-5.
  • 8
    Piattelli A, Fioroni M, Santinelli A, Rubini C. P53 protein expression in odontogenic cysts. J Endod 2001;27(7):459-61.
  • 9
    Lung K, Ganatra S, Robinson CE, Dobrovolsky W, Peters E. Multiple multilocular dentigerous cysts with intra-osseous and extra-osseous third molar displacement: a case report [cited 2012 Ago 10]. Available from: <http://www.oralhealthgroup.com/news/multiple-multilocular-dentigerous-cysts-with-intra-osseous-and-extra-osseous-third-molar-displacemen/1000204906/>.
    » http://www.oralhealthgroup.com/news/multiple-multilocular-dentigerous-cysts-with-intra-osseous-and-extra-osseous-third-molar-displacemen/1000204906/
  • 10
    Martinez-Perez D, Varela-Morales M. Conservative treatment of dentigerous cysts in children: a report of 4 cases. J Oral Maxillofac Surg. 2001;59(3):331-3. doi: 10.1053/joms.2001.21006
    » https://doi.org/10.1053/joms.2001.21006
  • 11
    Kasaboglu O, Basal Z, Usubutun A. Glandular odontogenic cyst presenting as a dentigerous cyst: a case report. J Oral Maxillofac Surg. 2006;64(4):731-3.
  • 12
    Yasuoka T, Yonemoto K, Kato Y, Tatematsu N. Squamous cell carcinoma arising in a dentigerous cyst. J Oral Maxillofac Surg. 2000;58(8):900-5. doi: 10.1053/joms.2000.8219
    » https://doi.org/10.1053/joms.2000.8219
  • 13
    Gulbranson SH, Wolfrey JD, Raines JM, Mcnally BP. Squamous cell carcinoma arising in a dentigerous cyst in a 16-month-old girl. Otolaryngol Head Neck Surg. 2002;127(5):463-4. doi: 10.1067/mhn.2002.129039
    » https://doi.org/10.1067/mhn.2002.129039
  • 14
    Smith JL 2(nd); Kellman RM. Dentigerous cysts presenting as head and neck infections. Otolaryngol Head Neck Surg. 2005;133(5):715-7. doi: 10.1016/j.otohns.2005.07.014
    » https://doi.org/10.1016/j.otohns.2005.07.014
  • 15
    Ertas U, Yavuz MS. Interesting eruption of 4 teeth associated with a large dentigerous cyst in mandible by only marsupialization. J Oral Maxillofac Surg 2003;61(6):728-30. doi: 10.1053/joms.2003.50145
    » https://doi.org/10.1053/joms.2003.50145
  • 16
    Peterson LJ, Edward E, Hupp JR, Myron RT. Cirurgia oral e maxilofacial contemporânea. 2ª ed. Rio de Janeiro: Guanabara Koogan; 2000.
  • 17
    Ellis E, Zide MF. Surgical aprroaches to the facial skeleton. 2 ed. Baltimore: Williams & Wilkins; 2006.
  • 18
    Mintz S, Allard M, Nour R. Extraoral removal of mandibular odontogenic dentigerous cysts: a report of 2 cases. J Oral Maxillofac Surg. 2001;59(9):1094-6. doi: 10.1053/joms.2001.25857
    » https://doi.org/10.1053/joms.2001.25857
  • 19
    Chew YS, Aghabeigi B. Spontaneous regression of bilateral dentigerous cysts: a case report. Dent Update. 2008;35(1):63-5.
  • 20
    Shah N, Thuau H, Beale I. Spontaneous regression of bilateral dentigerous cysts associated with impacted mandibular third molars. Br Dent J. 2002;192(2):75-6. doi:10.1038/sj.bdj.4801297
    » https://doi.org/10.1038/sj.bdj.4801297

Publication Dates

  • Publication in this collection
    Jul-Sep 2014

History

  • Received
    19 June 2013
  • Reviewed
    28 Aug 2013
  • Accepted
    17 Feb 2014
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