A patient with Chagas' Disease and mega-ileum is described. White, 41 years old, he presented a story of 3 years duration of crises of intestinal cramps, followed by abdominal distension and diarrhea. Between the crises, which became more intensive and more frequent, the patient did not present any complaint. The diagnosis of mega-ileum was made by small bowel radiological study. At histology of a biopsy fragment obtained during laparotomy, the denervation of mienteric plexus was confirmed.