Variation in response of Schistosoma mansoni strains to schistosomicides

Luiz Cândido de Souza Dias John I. Bruce Gerald C. Coles About the authors

Abstract

The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated.

Schistosoma mansoni; Experimental chemotherapy; resistance to drugs


ORIGINAL ARTICLES

Variation in response of Schistosoma mansoni strains to schistosomicides(1 (1 ) This study was supported in part by the Research Foundation of São Paulo State, (FAPESP) Brazil and NIAID grant no. 1R21-A1-20171-01 to the Center for Tropical Diseases, University of Lowell, Lowell. Massachusetts, U.S.A. )

Luiz Cândido de Souza DiasI; John I. BruceII; Gerald C. ColesIII

IState University of Campinas. Department of Parasitology. CP 6109. CEP 13081, Campinas, São Paulo, Brazil

IICenter for Tropical Diseases. College of Pure and Applied Science, University of Lowell, Lowell, Massachusetts 01854, U.S.A

IIIDepartment of Zoology, University of Massachusetts. Amherst, Massachusetts 01003, U.S.A

SUMMARY

The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated.

Key words:Schistosoma mansoni; Experimental chemotherapy - resistance to drugs.

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ACKNOWLEDGEMENTS

We are grateful to Dr. Yung-san Liang for valuable suggestions concerning this study and to Mr. David A. Boyd and Ms. Deborah M. Russel for their valuable technical assistance. Our thanks are also extended to Ms. Allison M. Howard for typing the manuscript. Support for this study was provided in part by the Research Foundation of São Paulo State (FAPESP), Brazil and by Grant No. 1R21-AI-20171-01 from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), United States of America.

Recebido para publicação em 21/12/1987.

  • (1
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    (1 ) This study was supported in part by the Research Foundation of São Paulo State, (FAPESP) Brazil and NIAID grant no. 1R21-A1-20171-01 to the Center for Tropical Diseases, University of Lowell, Lowell. Massachusetts, U.S.A.

    Publication Dates

    • Publication in this collection
      17 Feb 2011
    • Date of issue
      Apr 1988

    History

    • Received
      21 Dec 1987
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