Polyclonal B-cell activation in human malaria: relevance to the development of anti-sporozoite specific immune response and of immunopathology in individuals from endemic areas (Rondonia State - Brazil)

Daniel-Ribeiro, Claudio; Banic, Dalma Maria; Oliveira-Ferreira, Joseli de; Issa-Ahmed, Ishiraf; Teva, Antonio

doi:10.1590/S0036-46651988000600005

ORIGINAL ARTICLES

Department of Immunology (WHO Collaborating Center for Research and Training in Immunology of Parasitic Diseases). Institute Oswaldo Cruz - Fundação Oswaido Cruz. Caixa Postal 926. CEP 20001 Rio de Janeiro Brazil

Key words: Malaria, Polyclonal B cell activation; Anaemia; Immunoglobulin sensitization of erythrocytes; Anti-sporozoite antibodies; Immunoradiometnc assay; Plaque forming cell; Man.

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ACKNOWLEDGEMENTS

We are indebt to Drs. Agostinho Cruz Marques, João Bosco Pereira and Romeu Rodrigues Fialho from SUCAM and Mário Lemos Filho, Orlando Justino de Araújo, Percival da Costa Pinheiro Machado and Sandra Ferraciole from the Fundação SESP for all the facilities provided during the work in the field. We also thank Mr. Oseas Borges da Silva Fundação SESP. This study received financial support from the CNPq - Brazil (Polonoroeste proc. nº 700.418/85 - and PIDE VI proc. nº 401052/85) and the UNDP/ World Bank/Bank/WHO Special Programme for Research and Training in Tropical Diseases - ID 78618, CDR, DMB, IIA and JOF are recipients of a grant from CNPq.

Nota. Este trabalho faz parte do Projeto Polonoroeste CNPq e como os demais, nao foi submetido a avaliação do Corpo Redatorial da Revista do Instituto de Medicina Tropical de São Paulo.

1. BURGER, L.; DANIEL RIBEIRO, C. & BALLET, J. J. - Kinetics and composition of polyclonal B cell activation during lethal P. yoelii (17 XL) infection in CBA/J and swiss OF 1 mice. (Submitted).
2. CORSINI, A. C. & COSTA, M. G. - Immunosuppression in mice infected with Trypanosoma cruzi (Chagas, 1909) I. Evidences of polyclonal B cell activation in experimental infections mimicked by an extract prepared from circulating trypomastigotes Rev. Inst. Med. trop. S. Paulo 23: 114-121, 1981a.
3. CORSINI, A. C. & COSTA, M. G. - Immunosuppression in mice infected with Trypanosoma cruzi (Chagas, 1909). II Trypomastigote crude extract (TCE) suppress the humoral immune response in mice. Rev. Inst. Med. trop. S. Paulo, 23: 122-126, 1981b.
4. DANIEL RIBEIRO, C. - L'activation polyclonale des cellules-B,, l'autoimmunite et l'immunosuppression au cours du paludisme. Paris, 1983. (These Doctorat d'Etat, Universite Paris VI)
5. DANIEL RIBEIRO, C.; BANIC, D. M.; ISSA-AHMED, I. & GALVÃO CASTRO, B. - Polyclonal B-lymphocite activation and sensitization of erythrocytes by IgG in human malaria: relevance to the development of anaemia in a holoendemic area in northwestern Brazil (Ariquernes Rondônia). Mem. Inst. Oswaldo Cruz, 1 (Supp. II). 169-176, 1986.
6. DANIEL RIBEIRO, C.; OLIVEIRA-FERREIRA, J.; BANIC, D. M. & GALVÃO CASTRO, B. - Can malaria associated polyclonal B lymphocyte activation interfere with the development of anti-sporozoites specific immunity? Trans. roy. Soc. trop. Med. Hyg., 82, 1988. (In press).
7. DIAMANTSTEIN, T.; KEPPLER, W.; BLITSTEIN WILLINGER, E. & BEN-EFRAIN, S. - Suppression of the primary immune response in vivo to sheep red blood cells by B-cell mitogens. Immunology, 30: 401-407. 1976.
8. HAMMARSTROM, L.; SMITH, E.; PRIMI, D. & MOLLER, G. - Induction of autoantibodies to red blood cells by polyclonal cell activators. Nature, 263: 60-61, 1976.
9. LAMBERT, P. H.; MOREL, P. A.; RENVERSEZ, J. C. & GOLDMAN, M. - Idiotypic interactions and immune complexes in infections diseases. In: YAMAMURA, V. Y. & TADA, T., ed. - Progress in immunology. New York, Academic Press, 1983. p. 1343.
10. ORJIH, A. V. & NUSSENZWEIG, R. S. - Plasmodium berghei: suppression of antibody response to sporozoite stage by acute blood stage infection. Clin. exp. Immunol., 38: 1-8, 1979.
11. ROSENBERG, Y. J. - Autoimmune and polyclonal B cell responses during murine malaria. Nature, 274: 170-172. 1978.
12. SEED, T. M. & KREIR, J. P. - In: KREIER. J. P. ed. - Malaria, vol. 2. Pathology vector studies and culture. New York. Academic Press, 1980 p. 1-46.
13. WOODRUFF, A. W.; ANSDELL, V. E. & PETTITT, L. E. - Cause of anaemia in malaria. Lancet, 1: 1055-1057, 1979.
14. ZUCKERMAN, A - Recent studies on factors involved in malarial anaemia. Milit. Med., 131 (Suppl. 9): 1201-1216, 1966.