Reduced schedule of human anti-rabies immunization with Fuenzalida & Palacios vaccine: additional data

Esquema reduzido de imunização anti-rábica humana com vacina Fuenzalida & Palacios: dados adicionais

S.R. Favoretto M.L. Carrieri M.S. Tino A. Assis C.R. Zanetti O.A.C. Pereira About the authors

Abstracts

It was reevaluated a reduced schedule for anti-rabies post-exposure immunization with newborn mice nervous tissue vaccine (Fuenzalida 8c Palacios) in a group of 30 non exposed volunteers. The vaccine was administered by intramuscular injections on days zero, 2, 4, 16 and 27, in the deltoid area. Antibody levels were determinated by a simplified serum neutralization microtest on days zero, 16 and 37. On days 16 and 37 the antibody levels of the whole group was >0.5 IU/ml and >1.0 IU/ml, respectively. The cell mediated immunity was precociously detected (on day 4) by the delayed type hipersensitivity skin test. Our results show that this reduced schedule elicited an early and effective humoral and cellular immune response. However it is necessary other studies with larger groups of vaccinees in order to obtain definitive conclusion.

Human Anti-rabies Immunization; Reduced Schedule; Humoral and cellular immune responses


Foi reestudado em um grupo adicional de 30 voluntários não expostos ao contágio um esquema reduzido para imunização pós-exposi-ção com vacina de sistema nervoso de camundongos recém-nascidos (Fuenzalida ; Palacios). A vacina foi administrada nos dias zero, 2, 4, 16 e 27. A resposta imune humoral foi avaliada por soroneutralização em cultura celular nos dias zero, 16 e 37. Já no dia 16 os títulos de anticorpos foram > 0.5 UI/ml e no dia 37 > 1.00 UI/ml. A resposta imune celular foi avaliada no dia 4 pelo teste cutâneo de hipersensibilidade tardia. Foram obtidos resultados positivos em todos os 30 voluntários estudados.


IMUNOLOGY

Reduced schedule of human anti-rabies immunization with Fuenzalida & Palacios vaccine. Additional data

Esquema reduzido de imunização anti-rábica humana com vacina Fuenzalida & Palacios. Dados adicionais

S.R. FavorettoI; M.L. CarrieriI; M.S. TinoII; A. AssisIII; C.R. ZanettiI; O.A.C. PereiraI

IInstituto Pasteur de São Paulo

IIEscola Paulista de Medicina - Disciplina de Imunologia

IIISecretaria de Agricultura, Abastec. e Meio Ambiente de Mogi-Guaçu

Address for correspondence

SUMMARY

It was reevaluated a reduced schedule for anti-rabies post-exposure immunization with newborn mice nervous tissue vaccine (Fuenzalida 8c Palacios) in a group of 30 non exposed volunteers.

The vaccine was administered by intramuscular injections on days zero, 2, 4, 16 and 27, in the deltoid area.

Antibody levels were determinated by a simplified serum neutralization microtest on days zero, 16 and 37.

On days 16 and 37 the antibody levels of the whole group was >0.5 IU/ml and >1.0 IU/ml, respectively.

The cell mediated immunity was precociously detected (on day 4) by the delayed type hipersensitivity skin test.

Our results show that this reduced schedule elicited an early and effective humoral and cellular immune response. However it is necessary other studies with larger groups of vaccinees in order to obtain definitive conclusion.

Key words: Human Anti-rabies Immunization; Reduced Schedule; Humoral and cellular immune responses.

RESUMO

Foi reestudado em um grupo adicional de 30 voluntários não expostos ao contágio um esquema reduzido para imunização pós-exposi-ção com vacina de sistema nervoso de camundongos recém-nascidos (Fuenzalida ; Palacios).

A vacina foi administrada nos dias zero, 2, 4, 16 e 27.

A resposta imune humoral foi avaliada por soroneutralização em cultura celular nos dias zero, 16 e 37.

Já no dia 16 os títulos de anticorpos foram > 0.5 UI/ml e no dia 37 > 1.00 UI/ml.

A resposta imune celular foi avaliada no dia 4 pelo teste cutâneo de hipersensibilidade tardia. Foram obtidos resultados positivos em todos os 30 voluntários estudados.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

ACKNOWLEDGMENTS

The authors wish to thank all volunteers who took part in this work. They gratefully acknowledge Mrs. Maria Aparecida da Silva, Mrs. Dolores Ayako Yoda and Mr. José Luiz de Carvalho Jr. for the technical assistence. This work was supported by the Secretary of Health of the State of São Paulo and CNPq.

  • Address for correspondence:
    Silvana R. Favoretto
    Instituto Pasteur de São Paulo
    Av. Paulista, 393
    CEP 01311-000 - São Paulo - Brasil
  • Recebido para publicação em 14/06/1992

    Aceito para publicação em 16/10/1992

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    Address for correspondence: Silvana R. Favoretto Instituto Pasteur de São Paulo Av. Paulista, 393 CEP 01311-000 - São Paulo - Brasil

    Publication Dates

    • Publication in this collection
      20 July 2006
    • Date of issue
      June 1993

    History

    • Accepted
      16 Oct 1992
    • Received
      14 June 1992
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