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Case Report • Rev. Inst. Med. Trop. São Paulo 56 (5) • Sep-Oct 2014 • https://doi.org/10.1590/S0036-46652014000500012 linkcopy

Open-access FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE

Primeiro relato de ototoxicidade pelo antimoniato de meglumina

AuthorshipSCIMAGO INSTITUTIONS RANKINGS

    Abstracts

    Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions.

    Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted.

    Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.

    Mucocutaneous Leishmaniasis; Drug Toxicity; Meglumine antimoniate; Hearing loss; Tinnitus; Dizziness

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    Instituto de Medicina Tropical de São Paulo Av. Dr. Enéas de Carvalho Aguiar, 470, 05403-000 - São Paulo - SP - Brazil, Tel. +55 11 3061-7005 - São Paulo - SP - Brazil
    E-mail: revimtsp@usp.br
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