Intestinal cryptosporidiosis. association with Pneumocystis carinii, cytomegalovirus and Candida sp. Infections

Coelho, K. I. R.; Maeda, S. A.; Marques, M. E. A.

doi:10.1590/S0036-46651987000500010

Abstracts

This is a case report of intestinal cryptosporidiosis diagnosed in histological specimen collected from autopsy. The patient was a child of 5 months admitted to the hospital with severe acute diarrhea associated with Pneumocystis carinii pneumonia, cytomegalic sialadenitis, oral and dermal candidiasis. The presence of multiple opportunistic infections in this case indicated immunodeficiency state. Cryptosporidium sp is a possible etiology of acute diarrhea in both immunodeficient and immunocompetent patients and has to be searched for at autopsy when diagnosis was not possible "in vivo".

Immunodeficiency; Diarrhea; Cryptosporidiosis

Criptosporidiose intestinal associada a infecções por Pneumocystis carinii, cytomegalovirus e Candida sp. Trata-se de apresentação de um caso de criptosporidiose intestinal diagnosticada histologicamente em material de autópsia. A paciente era uma criança de 5 meses, internada com diarréia aguda grave, associada a pneumonia por Pneumocystis carinii, sialadenite citomegálica e candidíase oral e cutânea. A presença de infecções oportunísticas múltiplas indicaram o diagnóstico de imunodeficiência. Cryptosporidium sp é uma possibilidade etiológica para diarréias agudas em pacientes imunodeprimidos ou imunocompetentes e deve ser procurado em material de autópsia quando não diagnosticado "in vivo".

CASE REPORT

Intestinal cryptosporidiosis. Association with Pneumocystis carinii, cytomegalovirus and Candida sp. Infections

K. I. R. Coelho; S. A. Maeda; M. E. A. Marques

^{Address for correspondence} Address for correspondence: Dra. Kunie Iabuki R. Coelho Departamento de Patologia da Faculdade de Medicina de Botucatu CEP 18600 Botucatu, SP., Brasil

SUMMARY

This is a case report of intestinal cryptosporidiosis diagnosed in histological specimen collected from autopsy. The patient was a child of 5 months admitted to the hospital with severe acute diarrhea associated with Pneumocystis carinii pneumonia, cytomegalic sialadenitis, oral and dermal candidiasis. The presence of multiple opportunistic infections in this case indicated immunodeficiency state.

Cryptosporidium sp is a possible etiology of acute diarrhea in both immunodeficient and immunocompetent patients and has to be searched for at autopsy when diagnosis was not possible "in vivo".

Key words: Immunodeficiency; Diarrhea; Cryptosporidiosis.

RESUMO

Criptosporidiose intestinal associada a infecções por Pneumocystis carinii, cytomegalovirus e Candida sp.

Trata-se de apresentação de um caso de criptosporidiose intestinal diagnosticada histologicamente em material de autópsia.

A paciente era uma criança de 5 meses, internada com diarréia aguda grave, associada a pneumonia por Pneumocystis carinii, sialadenite citomegálica e candidíase oral e cutânea. A presença de infecções oportunísticas múltiplas indicaram o diagnóstico de imunodeficiência.

Cryptosporidium sp é uma possibilidade etiológica para diarréias agudas em pacientes imunodeprimidos ou imunocompetentes e deve ser procurado em material de autópsia quando não diagnosticado "in vivo".

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Recebido para publicação em 02/12/86.

1. BOGAERTZ, J.; LEPAGE, P.; ROUVROY, D. & VANDEPITTE, J. - Cryptosporidium sp, a frequent cause of diarrhea in Central Africa. J. clin. Microbiol., 20: 874-876, 1984.
2. CHIAMPI, N. P.; SUNDBERG, R. D.; KLOMPUS, J P. & WILSON, A. J. - Cryptosporidial enteritis and Pneumocystis pneumonia in a homossexual man. Hum. Path., 14: 734-737, 1983.
3. CURENT, W. L.; REESE, N. C.; ERNST, J. V.; BAILEY, W. S.; HEYMAN, M. B. & WEINSTEIN, W. M. - Human cryptosporidiosis in immunocompetent and imunodeficient persons. New Engl. J. Med.; 308: 1252-1257, 1983.
4. LOUREIRO, E. C. B.; LINHARES, A. C & MATA. L. - Acute diarrhoea associated with Cryptosporidium sp in Belem, Brazil. Rev. Inst. Med. trop. S. Paulo, 28: 138-140, 1986.
5. MATA, L. - Cryptosporidium and other protozoa in diarrheal disease in less developed countries. Pediat. infect. Dis., 5 (Supplement): S117-S130, 1986.
6. MILLER, R. A.; WASSERHEIT, J. N.; KIRIHARA, J. & COYLE, M. B. - Detection of Cryptosporidium oocysts in sputum during screening for mycobacteria. J. clin. Microbiol., 20: 1192-1193,1984.
7. REESE, N. C.; CURRENT, W. L.; ERNST, J. V. & BAILEY, W. S. - Cryptosporidiosis of man and calf. A case report and results of experimental infections in mice and rats. Amer. J. trop. Med. Hyg., 31: 226-229, 1982.
8. REICHERT, C. M.; O'LEARY, T. J.; LEVENS, D. L.; SIMRELL, C. R. & MACHER, A. M. - Autopsy pathology in the acquired immunodeficiency syndrome. Amer. J. Path., 112: 357-382, 1983.
9. ROGERS, M. F. - AIDS in children: a review of the clinical, epidemiologic and public health aspects. Pediat. Infect. Dis., 4: 230-236, 1985.
10. WEIDERMANN, B. L.; KAPLAN, S. L. & MARINO, B. - Prevalence and significance of cryptosporidiosis in children. Pediat. infect. Dis., 4: 292-293, 1985.
11. WEIKEL, C. S.; JOHNSTON, L. I.; DE SOUZA, M. & GUERRANT, R. L. - Cryptosporidiosis in northeastern Brazil. Association with sporadic diarrhea. J. infect. Dis., 151: 963-965, 1985.

Address for correspondence:

Dra. Kunie Iabuki R. Coelho

Departamento de Patologia da Faculdade de Medicina de Botucatu

CEP 18600 Botucatu, SP., Brasil

Publication Dates

Publication in this collection
17 Feb 2011
Date of issue
Oct 1987

History

Received
02 Dec 1986

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BOGAERTZ, J.; LEPAGE, P.; ROUVROY, D. & VANDEPITTE, J. - Cryptosporidium sp, a frequent cause of diarrhea in Central Africa. J. clin. Microbiol., 20: 874-876, 1984.

[2] 2. CHIAMPI, N. P.; SUNDBERG, R. D.; KLOMPUS, J P. & WILSON, A. J. - Cryptosporidial enteritis and Pneumocystis pneumonia in a homossexual man. Hum. Path., 14: 734-737, 1983.

[3] 3. CURENT, W. L.; REESE, N. C.; ERNST, J. V.; BAILEY, W. S.; HEYMAN, M. B. & WEINSTEIN, W. M. - Human cryptosporidiosis in immunocompetent and imunodeficient persons. New Engl. J. Med.; 308: 1252-1257, 1983.

[4] 4. LOUREIRO, E. C. B.; LINHARES, A. C & MATA. L. - Acute diarrhoea associated with Cryptosporidium sp in Belem, Brazil. Rev. Inst. Med. trop. S. Paulo, 28: 138-140, 1986.

[5] 5. MATA, L. - Cryptosporidium and other protozoa in diarrheal disease in less developed countries. Pediat. infect. Dis., 5 (Supplement): S117-S130, 1986.

[6] 6. MILLER, R. A.; WASSERHEIT, J. N.; KIRIHARA, J. & COYLE, M. B. - Detection of Cryptosporidium oocysts in sputum during screening for mycobacteria. J. clin. Microbiol., 20: 1192-1193,1984.

[7] 7. REESE, N. C.; CURRENT, W. L.; ERNST, J. V. & BAILEY, W. S. - Cryptosporidiosis of man and calf. A case report and results of experimental infections in mice and rats. Amer. J. trop. Med. Hyg., 31: 226-229, 1982.

[8] 8. REICHERT, C. M.; O'LEARY, T. J.; LEVENS, D. L.; SIMRELL, C. R. & MACHER, A. M. - Autopsy pathology in the acquired immunodeficiency syndrome. Amer. J. Path., 112: 357-382, 1983.

[9] 9. ROGERS, M. F. - AIDS in children: a review of the clinical, epidemiologic and public health aspects. Pediat. Infect. Dis., 4: 230-236, 1985.

[10] 10. WEIDERMANN, B. L.; KAPLAN, S. L. & MARINO, B. - Prevalence and significance of cryptosporidiosis in children. Pediat. infect. Dis., 4: 292-293, 1985.

[11] 11. WEIKEL, C. S.; JOHNSTON, L. I.; DE SOUZA, M. & GUERRANT, R. L. - Cryptosporidiosis in northeastern Brazil. Association with sporadic diarrhea. J. infect. Dis., 151: 963-965, 1985.