Alcalde-Vargas et al.15
|
Case report |
Low/High |
79 |
F |
Previous antibiotic treatment (beta-lactam and subsequent fluoroquinolone), older age |
Blood |
Pseudomembraneous colitis and bacteremia |
Metronidazole |
Not reported |
15 days |
Clinical improvement |
Brasha et al.24
|
Case report |
Low/Low |
37 |
F |
Large uterine fibroid myoma |
Pus from uterine fibroid tissue |
Postpartum pyomyoma |
Piprecillin/tazobactam (in hospital) Amoxicillin/clavulanic acid (at discharge) |
Piprecillin/tazobactam 4.5 (4/0.5) g / 8h Amoxicillin/clavulanic 625 (500 /125) mg / 8h |
Piprecillin/tazobactam for at least 5 days Amoxicillin/clavulanic acid for 14 days |
Clinical improvement |
Brook4
|
Case series |
Low/Unclear Low/Unclear* *selection/information bias
|
3.5 |
F |
Unknown disease of gastrointestinal tract |
Blood |
Bloodstream infection |
Penicillin |
Not reported |
Not reported |
Complete recovery |
Brook4
|
Case series |
Low/Unclear Low/Unclear* *selection/information bias
|
3.5 |
M |
Young preschooler child |
Middle ear |
Acute otitis media |
Amoxicillin |
Not reported |
Not reported |
Complete recovery |
Dayha et al.9
|
Case report |
Low/Unclear |
26 |
M |
Traumatic injury (open tibial shaft fracture treated with intramedullary interlocking nail fixation) |
Blood and postoperative wound |
Osteomyelitis |
Vancomycin plus tigecycline |
Not reported |
12 weeks |
Failure of antibiotic treatment led to amputation |
García-Jiménez et al.7
|
Case series |
Low/Low High/Unclear* *selection/information bias
|
62 |
F |
Rheumatoid arthritis with implanted prosthetic joint |
Joint fluid and intraoperative cultures |
Septic arthritis |
Initially Meropenem + metronidazole, switched to IV penicillin + clindamycin + metronidazole |
Not reported |
Meropenem+ Metronidazole 6 weeks; IV penicillin+ Clindamycin (unknown duration) plus Metronidazole for 3 months |
Clinical improvement |
García-Jiménez et al.7
|
Case series |
Low/Low High/Unclear* *selection/information bias
|
53 |
M |
Chronic renal failure/hemodialysis |
Blood and abscess aspirate |
Septic arthritis |
Initially ampicillin + Gentamycin, switched to amoxicillin- clavulanate |
Not reported |
Ampicillin+ Gentamycin 6 weeks; Amoxicillin- clavulanate 6 weeks |
Clinical improvement |
Gerber et al.17
|
Case report |
Low/High |
74 |
M |
Alcoholic liver cirrhosis with hepatorenal syndrome treated initially with hemo- and peritoneal dialysis, older age |
Peritoneal fluid |
Peritonitis leading to sepsis |
Initially IP cefazolin + Ceftazidime, switched to IV Ceftazidime + Vancomycin (ET was not effective), switched to comfort care |
Not reported |
Not reported |
Unclear |
Gollapudi et al.20
|
Case series |
Low/Unclear High/Unclear* **selection/information bias
|
66 |
F |
Hematological cancer, older age |
Blood |
Bloodstream infection |
Cefepime + Metronidazole (ET) |
Not reported |
Not reported |
Clinical improvement |
Gollapudi et al.20
|
Case series |
Low/Unclear High/Unclear* **selection/information bias
|
79 |
M |
Hematological cancer, older age |
Blood |
Bloodstream infection |
Ceftazidime + Metronidazole (ET) |
Not reported |
Not reported |
Death |
Kozaki et al.18
|
Case report |
Low/Low |
73 |
M |
Diabetes mellitus, older age |
Aortic wall and surrounding tissue samples during surgery |
Infected thoracic aortic aneurysm |
Initially meropenem+ Metronidazole, switched to minocycline |
Meropenem 0.5g/6h, Metronidazole 0.5g/8h |
Meropenem+ Metronidazole 7 days; Immunoglobulin 3 days; Minocycline not reported |
Complete recovery |
Lavigne et al.14
|
Case report |
Low/Low |
74 |
M |
Prostatic adenoma, older age |
Diskal puncture aspirate |
Spondylodiscitis |
Initially, IV Amoxicillin + p.o. Metronidazole, switched to oral amoxicilline and metronidazole at discharge |
IV and oral amoxicillin 2 g/8h, Metronidazole 0.5g/8h |
IV amoxicilline plus Metronidazole 4 weeks; Oral amoxicillin plus Metronidazole 4 weeks |
Clinical improvement |
Lim et al.21
|
Case series |
Low/Low High/Unclear* *selection and information bias
|
89 |
F |
Colon cancer, older age |
Blood |
Bloodstream infection |
Initially, ceftriaxone, switched to tigecycline |
Not reported |
Ceftriaxone 2 days; Tigecycline- not reported |
Clinical improvement |
Lim et al.21
|
Case series |
Low/Low High/Unclear* *selection and information bias
|
70 |
M |
Infected pressure ulcers, older age |
Blood |
Bloodstream infection |
Meropenem plus teicoplanin |
Not reported |
Unclear |
Clinical improvement |
Lorleac’h et al.26
|
Case report |
Low/Unclear |
72 |
M |
Bioprosthetic aortic valve replacement due to aortic stenosis, older age |
Blood |
Endocarditis |
Amoxicillin |
Not reported |
Not reported |
Clinical improvement |
Mohandas et al.22
|
Case report |
Low/Unclear |
91 |
F |
Arterial hypertension, diabetes mellitus, infected pressure ulcers, older age |
Blood |
Bloodstream infection and osteomyelitis |
Ampicilin-sulbactam+ gentamicin |
Not reported |
Not reported |
Clinical improvement |
Set et al.10
|
Case report |
Low/Unclear |
5 |
M |
Chronic suppurative otitis media in ayoung preschooler child |
Cerebellar abscess with pus |
Cerebellar abscess |
Ampicillin + Chloramphenicol + Metronidazole |
Not reported |
Not reported |
Clinical improvement |
Turcoglu et al.25
|
Case report |
Low/Unclear |
7 |
M |
Invasive diagnostic and therapeutic procedures due to pleural empyema, brain hydatid disease |
Hydatid cyst fluid |
Infected intracranial hydatid cyst |
Meropenem |
Not reported |
28 days |
Clinical improvement |
Zakham et al.8
|
Case report |
Low/Low |
26 |
F |
Ewing sarcoma |
Bone and tissue fragment |
Septic pseudoarthrosis |
Clindamycin |
0.6g/8h |
8 months |
Complete recovery |