In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis

Actividad in vitro de surfactante pulmonar clínico Surfacen® frente a Leishmania amazonensis

Odalys Blanco Yuliannis Lugones Elaine Díaz Lianet Monzote About the authors

Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®.

Leishmania amazonensis; Pulmonary surfactant; Antibiotic activity; Antimicrobial; SP-B

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