Reinfections and rotavirus serotypes in Belém, Brazil

Linhares, Alexandre da C.; Gabbay, Yvone B.; Freitas, Ronaldo B. de; Mascarenhas, Joana D'arc P.

doi:10.1590/S0036-46651988000200009

Abstracts

Repeated infections involving different rotavirus serotypes were detected in four children living in Belém, who were followed up since birth to three years of age. In one child (Reg. 23.983) three successive symptomatic infections (one of them associated with serotype 2) were noted: the first, at four months of age, the second at 20 months and the third at 27 months. Another child had two subsequent infections, the first one by rotavirus serotype 1, and the second by a not identified rotavirus serotype. In this case two episodes of rotavirus-related diarrhoea were recorded, occurring eight months apart. Apparent infections were detected on two occasions involving the same child (Reg. 24.004), the first being associated with serotype 1, and the second with serotype 2. The fourth child (Reg. 24.097) had two successive infections by not determined rotavirus serotypes, without clinical manifestations; the first occurred at 24 months and the second at 28 months.

Rotavirus; Reinfections; Children; Serotypes

Infecções sucessivas causadas por rotavírus foram detectadas em quatro crianças habitantes de Belém, acompanhadas desde seu nascimento até os três anos de idade. Em uma delas (Reg. 23.983) três infecções sintomáticas foram observadas, duas por sorotipo não especificado e outra pelo 2: a primeira aos 4 meses, a segunda aos 20, e a terceira aos 27. Outro indivíduo (Reg. 24.384) apresentou dois episódios diarréicos, com intervalo de oito meses, o primeiro por sorotipo 1 e o segundo por sorotipo não identificado. Infecções também aparentes foram observadas em duas ocasiões envolvendo a mesma criança (Reg. 24.004), a primeira por sorotipo 1 e, doze meses após. uma segunda pelo 2. Em uma outra criança (Reg. 24.097) duas infecções, ambas inaparentes e por sorotipo nao especincado, foram detectadas: a primeira aos 24 meses de vida e a segunda, aos 28.

PRELIMINARY REPORT

Reinfections and rotavirus serotypes in Belém, Brazil

Reinfecções e sorotipos de rotavirus em Belém, Brasil

Alexandre da C. Linhares; Yvone B. Gabbay; Ronaldo B. de Freitas; Joana D'arc P. Mascarenhas

Instituto Evandro Chagas, Fundação Serviços de Saúde Pública, Ministério da Saúde. Av. Almirante Barroso, 492. Caixa Postal 621. CEP 66050 Belém, Pará, Brasil

SUMMARY

Repeated infections involving different rotavirus serotypes were detected in four children living in Belém, who were followed up since birth to three years of age. In one child (Reg. 23.983) three successive symptomatic infections (one of them associated with serotype 2) were noted: the first, at four months of age, the second at 20 months and the third at 27 months. Another child had two subsequent infections, the first one by rotavirus serotype 1, and the second by a not identified rotavirus serotype. In this case two episodes of rotavirus-related diarrhoea were recorded, occurring eight months apart. Apparent infections were detected on two occasions involving the same child (Reg. 24.004), the first being associated with serotype 1, and the second with serotype 2. The fourth child (Reg. 24.097) had two successive infections by not determined rotavirus serotypes, without clinical manifestations; the first occurred at 24 months and the second at 28 months.

Key words: Rotavirus; Reinfections; Children; Serotypes.

RESUMO

Infecções sucessivas causadas por rotavírus foram detectadas em quatro crianças habitantes de Belém, acompanhadas desde seu nascimento até os três anos de idade. Em uma delas (Reg. 23.983) três infecções sintomáticas foram observadas, duas por sorotipo não especificado e outra pelo 2: a primeira aos 4 meses, a segunda aos 20, e a terceira aos 27. Outro indivíduo (Reg. 24.384) apresentou dois episódios diarréicos, com intervalo de oito meses, o primeiro por sorotipo 1 e o segundo por sorotipo não identificado. Infecções também aparentes foram observadas em duas ocasiões envolvendo a mesma criança (Reg. 24.004), a primeira por sorotipo 1 e, doze meses após. uma segunda pelo 2. Em uma outra criança (Reg. 24.097) duas infecções, ambas inaparentes e por sorotipo nao especincado, foram detectadas: a primeira aos 24 meses de vida e a segunda, aos 28.

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ACKNOWLEDGMENTS

This study was supported by a grant from WHO, Control of Diarrhoeic Diseases Program. We are indebted to the staffs of the sections of Virus, Bacteriology and Parasitology of "Instituto Evandro Chagas, Fundação Serviços de Saúde Pública", for excellent technical assistance. Thanks are due to Drs. T. H. Flewett and G. M. Beards for carrying out serotyping. We are also grateful to Mrs. Glads M. H. Diniz Marins for typing the manuscript.

Recebido para publicação em 16/7/1987.

1. BEARDS. G. M. - Serotyping of rotavirus by NADP - enhanced enzymeimmuno assay. J. med. Virol. (In press).
2. BEARDS, G. M.; CAMPBELL, A. D.; COTTREL, N. L.; PEIRIS. J. S. M.; REES, N.; SANDERS. R. C.; SHIRLEY, J. A.; WOOD, H. C. & FLEWETT, T. H. - Enzyme linked immunosorbent assay based on polyclonal and monoclonal antibodies for rotavirus detection. J. clin. Microbiol., 191: 248-254, 1984.
3. BISHOP, R. F.; BARNES, G. L.; CIPRIANI, E. & LUND, J. S. - Clinical immunity after neonatal rotavirus infection. A prospective longitudinal study in young children. New Engl. J. Med., 309: 72-76. 1983.
4. BLACK, R. E.; BROWN, K. H.; BECKER, S.; ALIM, A. R. M. A. & HUQ, I. - Longitudinal studies of reinfections diseases and physical growth of children in rural Bangla desh. II Incidence of diarrhoea and association with known pathogens. Amer. J. Epidemiol., 115: 315-322, 1982.
5. FONTEYNE, J.; ZISSIS, G. & LAMBERT, J. - Recurrent rotavirus gastroenteritis. Lancet., 1: 983, 1978.
6. GURWITH, M.; WENMAN, W.; GURWITH, D.; BRUNTON, J.; FELTHAM, S. & GREENBERG, H. - Diarrhoea among infants and young children in Canada: a longitudinal study in three Northern communities. J. infect. Dis., 147: 185-192, 1983.
7. KAPIKIAN, A. Z.; KIM, W. H.; WYATT, R. G.; CLINE, W. L.; ARROBIO, J. O.; BRANT, C. D.; RODRIGUEZ, W. J.; SACK, D. A.; CHANOCK, R. M. & PARROT, R. H. - Human rotavirus like agent as the major pathogen as sociated with "winter" gastroenteritis in hospitalized infants and young children. New Engl. J. Med., 294: 965-972, 1976.
8. KONNO, T. M.; SUZUKI, H.; HATSUSHIMA, N.; IMAI, A.; TAZAWA, F.; KUTSUAWA, T.; KITAOKA, S.; SAKAMOTO. M.; UAZAKI. N & ISHIDA. N. - Influence of temperature and relative humidity on human rotavirus infections in Japan. J. infect. Dis., 174: 125-128, 1983
9. LAEMMLI, U. K. - Cleavage of structural proteins during the assembly of the head of bacteriophage - T₄, Nature, 227: 680-685. 1970.
10. LINHARES, A. C.; FREITAS. R. B.; GABBAY, Y. B. & PEREIRA, J. D. M. - Reinfecções por rotavirus em crianças de Belém, Para, Brasil. Rev. Inst. Med. trop. S. Paulo, 28: 194-202, 1986.
11. LINHARES, A C; MONÇÃO. H. C.; GABBAY. Y B : DE ARAÚJO, V. L. C: SERRUYA, A. C. & LOUREIRO, E C. B. - Acute diarrhoea associated with rotavirus among children living in Belém, Pará, Brasil. Trans. roy. Soc. trop. Med. Hyg., 77: 384-390. 1983.
12. MATSUNO, S.; HASEGAWA. A.; MUKOYAMA. A. & INOUYE, S. - A candidate for a new serotype of human rotavirus. J. Virol., 54: 623-624. 1985.
13. MOOSAI, R. B.; ALCOCK, R. & MADELEY, C. R. - A cryptogram for recording rotavirus strains. The rotacode. J. Hyg. (Lond.), 93: 237-250. 1984.
14. MORISHIMA, T.; YAMAGUCHI, H.; NAGAYOSHI, S.; OZAKI, T.; ISOMURA, S. & SUZUKI, S. - Course of rotavirus gastroenteritis in a closed community. Arch. Dis. Childh., 55: 147-149, 1980.
15. RODRIGUEZ, W. J.; KIM, W. H.; BRANDT, C. D.; YOLKEN, R. H.; ARROBIO, J. O.; KAPIKIAN, A. Z.; CHANOCK, R. M. & PARROT, R H. Sequential enteric illnesses associated with different rotavirus serotypes. Lancet: 1: 37, 1978.
16 ROWLAND, M. G.; GOH, S. G. J.; WILLIAMS, K.; CAMPBELL, A. D.; BEARDS, G. M.; SANDERS, R. C. & FLEWETT, T. H. - Epidemiological aspects of rotavirus infection in young Gambian children. Ann. trop. Paed., 5: 23-31, 1985.
17. TOTTERDELL, B. M.; NICHOLSON, K. G.; MAC LEOD, J.; CHRYSTIE, I. L. & BANATVALA, J. E. - Neonatal rotavirus infection: role of lacteal neutralizing alpha I - anti-trypsin and nonimmunnoglobulin antiviral activity in protection. J. med. Virol., 10: 37-44, 1982.
18. YOLKEN, R. H.; WYATT, R. G.; ZISSIS, G.; BRANDT C. D.; RODRIGUEZ, W. J., KIM, H.; PARROT, W.; URRUTIA, R. H., MATA, L.; GREENBERG, H. B.; KAPIKIAN, A. Z. & CHANOCK, R. M. - Epidemiology of human rotavirus types 1 and 2 as studied by enzyme - linked immunosorbet assay. New Engl. J. Med., 299: 1156-1161, 1978.
19. WYATT, R. G.; JAMES, H. D.; PITTMAN, A. L.; HOSHINO. Y.; GREENBERG, H. B.; KALICA, A. R.; FLORES, J. & KAPIKIAN, A. Z. - Direct isolation in cell culture of human rotavirus and their characterization into four serotypes. J. clin. Microbiol. 18: 310-317, 1983.

Publication Dates

Publication in this collection
18 Feb 2011
Date of issue
Apr 1988

History

Received
16 July 1987

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BEARDS. G. M. - Serotyping of rotavirus by NADP - enhanced enzymeimmuno assay. J. med. Virol. (In press).

[2] 2. BEARDS, G. M.; CAMPBELL, A. D.; COTTREL, N. L.; PEIRIS. J. S. M.; REES, N.; SANDERS. R. C.; SHIRLEY, J. A.; WOOD, H. C. & FLEWETT, T. H. - Enzyme linked immunosorbent assay based on polyclonal and monoclonal antibodies for rotavirus detection. J. clin. Microbiol., 191: 248-254, 1984.

[3] 3. BISHOP, R. F.; BARNES, G. L.; CIPRIANI, E. & LUND, J. S. - Clinical immunity after neonatal rotavirus infection. A prospective longitudinal study in young children. New Engl. J. Med., 309: 72-76. 1983.

[4] 4. BLACK, R. E.; BROWN, K. H.; BECKER, S.; ALIM, A. R. M. A. & HUQ, I. - Longitudinal studies of reinfections diseases and physical growth of children in rural Bangla desh. II Incidence of diarrhoea and association with known pathogens. Amer. J. Epidemiol., 115: 315-322, 1982.

[5] 5. FONTEYNE, J.; ZISSIS, G. & LAMBERT, J. - Recurrent rotavirus gastroenteritis. Lancet., 1: 983, 1978.

[6] 6. GURWITH, M.; WENMAN, W.; GURWITH, D.; BRUNTON, J.; FELTHAM, S. & GREENBERG, H. - Diarrhoea among infants and young children in Canada: a longitudinal study in three Northern communities. J. infect. Dis., 147: 185-192, 1983.

[7] 7. KAPIKIAN, A. Z.; KIM, W. H.; WYATT, R. G.; CLINE, W. L.; ARROBIO, J. O.; BRANT, C. D.; RODRIGUEZ, W. J.; SACK, D. A.; CHANOCK, R. M. & PARROT, R. H. - Human rotavirus like agent as the major pathogen as sociated with "winter" gastroenteritis in hospitalized infants and young children. New Engl. J. Med., 294: 965-972, 1976.

[8] 8. KONNO, T. M.; SUZUKI, H.; HATSUSHIMA, N.; IMAI, A.; TAZAWA, F.; KUTSUAWA, T.; KITAOKA, S.; SAKAMOTO. M.; UAZAKI. N & ISHIDA. N. - Influence of temperature and relative humidity on human rotavirus infections in Japan. J. infect. Dis., 174: 125-128, 1983

[9] 9. LAEMMLI, U. K. - Cleavage of structural proteins during the assembly of the head of bacteriophage - T₄, Nature, 227: 680-685. 1970.

[10] 10. LINHARES, A. C.; FREITAS. R. B.; GABBAY, Y. B. & PEREIRA, J. D. M. - Reinfecções por rotavirus em crianças de Belém, Para, Brasil. Rev. Inst. Med. trop. S. Paulo, 28: 194-202, 1986.

[11] 11. LINHARES, A C; MONÇÃO. H. C.; GABBAY. Y B : DE ARAÚJO, V. L. C: SERRUYA, A. C. & LOUREIRO, E C. B. - Acute diarrhoea associated with rotavirus among children living in Belém, Pará, Brasil. Trans. roy. Soc. trop. Med. Hyg., 77: 384-390. 1983.

[12] 12. MATSUNO, S.; HASEGAWA. A.; MUKOYAMA. A. & INOUYE, S. - A candidate for a new serotype of human rotavirus. J. Virol., 54: 623-624. 1985.

[13] 13. MOOSAI, R. B.; ALCOCK, R. & MADELEY, C. R. - A cryptogram for recording rotavirus strains. The rotacode. J. Hyg. (Lond.), 93: 237-250. 1984.

[14] 14. MORISHIMA, T.; YAMAGUCHI, H.; NAGAYOSHI, S.; OZAKI, T.; ISOMURA, S. & SUZUKI, S. - Course of rotavirus gastroenteritis in a closed community. Arch. Dis. Childh., 55: 147-149, 1980.

[15] 15. RODRIGUEZ, W. J.; KIM, W. H.; BRANDT, C. D.; YOLKEN, R. H.; ARROBIO, J. O.; KAPIKIAN, A. Z.; CHANOCK, R. M. & PARROT, R H. Sequential enteric illnesses associated with different rotavirus serotypes. Lancet: 1: 37, 1978.

[16] 16 ROWLAND, M. G.; GOH, S. G. J.; WILLIAMS, K.; CAMPBELL, A. D.; BEARDS, G. M.; SANDERS, R. C. & FLEWETT, T. H. - Epidemiological aspects of rotavirus infection in young Gambian children. Ann. trop. Paed., 5: 23-31, 1985.

[17] 17. TOTTERDELL, B. M.; NICHOLSON, K. G.; MAC LEOD, J.; CHRYSTIE, I. L. & BANATVALA, J. E. - Neonatal rotavirus infection: role of lacteal neutralizing alpha I - anti-trypsin and nonimmunnoglobulin antiviral activity in protection. J. med. Virol., 10: 37-44, 1982.

[18] 18. YOLKEN, R. H.; WYATT, R. G.; ZISSIS, G.; BRANDT C. D.; RODRIGUEZ, W. J., KIM, H.; PARROT, W.; URRUTIA, R. H., MATA, L.; GREENBERG, H. B.; KAPIKIAN, A. Z. & CHANOCK, R. M. - Epidemiology of human rotavirus types 1 and 2 as studied by enzyme - linked immunosorbet assay. New Engl. J. Med., 299: 1156-1161, 1978.

[19] 19. WYATT, R. G.; JAMES, H. D.; PITTMAN, A. L.; HOSHINO. Y.; GREENBERG, H. B.; KALICA, A. R.; FLORES, J. & KAPIKIAN, A. Z. - Direct isolation in cell culture of human rotavirus and their characterization into four serotypes. J. clin. Microbiol. 18: 310-317, 1983.