The use of bioabsorbable polymers in the medical area has been increasing every year. Among the bioreabsorbable polymers mostly studied, is poly (L-lactide-co-glycolide), PLGA, whose main characteristic is to present short time of degradation and for that, applied as sutures, devices for controlled liberation of medicines and guided regeneration of fabric in contact with the bone, periodontia. The aim of this work was to synthesize, to characterize and to evaluate the in vitro degradation process of PLGA membranes. The copolymer was synthesized by ring opening of the cyclic diesters d of lactic acid and glicolic acid, using as catalyst Sn(Oct)2. PLGA presented high values of molar mass (Mw around 10(5) g/mol) and its chemical structure was confirmed by ¹H NMR, 13C NMR, and FTIR spectrometry data. The thermal properties of PLGA by DSC, confirmed that the polymer in this relation 80/20 is amorphous. In vitro degradation of PLGA membranes showed that the polymer became crystalline as a function of the degradation time.
synthesis; PLGA; in vitro degradation
