Potential drug-food interactions in patients hospitalized in the Cardiology Unit

ANJOS, Matheus Kirton dos; OLIVEIRA, Tainã Clarissa Santos da Silva de; MOREIRA, Maiara Benevides; MOREIRA, Samara Oliveira; STIPP, Marluci Andrade Conceição; PAES, Graciele Oroski

doi:10.1590/1678-9865201932e180147

person Matheus Kirton dos ANJOS

schoolUniversidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Escola de Enfermagem Anna Nery. R. Afonso Cavalcante, 275, Cidade Nova, Rio de Janeiro, RJ, Brasil. CONTRIBUTORS MK ANJOS was responsible for the design and conception of the research project, for the collection, analysis and interpretation of data, and for writing this paper. TCSS OLIVEIRA and MB MOREIRA were responsible for data collection. SO MOREIRA was responsible for reviewing this study. MAC STIPP was responsible for writing and critical review. GO PAES was responsible for research guidance, writing and critical review.

0000-0001-7016-026X

person Tainã Clarissa Santos da Silva de OLIVEIRA

schoolInstituto Nacional do Câncer, Residência Multiprofissional em Oncologia. Rio de Janeiro, RJ, Brasil. CONTRIBUTORS MK ANJOS was responsible for the design and conception of the research project, for the collection, analysis and interpretation of data, and for writing this paper. TCSS OLIVEIRA and MB MOREIRA were responsible for data collection. SO MOREIRA was responsible for reviewing this study. MAC STIPP was responsible for writing and critical review. GO PAES was responsible for research guidance, writing and critical review.

0000-0002-6091-2373

person Maiara Benevides MOREIRA

schoolUniversidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Escola de Enfermagem Anna Nery. R. Afonso Cavalcante, 275, Cidade Nova, Rio de Janeiro, RJ, Brasil. CONTRIBUTORS MK ANJOS was responsible for the design and conception of the research project, for the collection, analysis and interpretation of data, and for writing this paper. TCSS OLIVEIRA and MB MOREIRA were responsible for data collection. SO MOREIRA was responsible for reviewing this study. MAC STIPP was responsible for writing and critical review. GO PAES was responsible for research guidance, writing and critical review.

0000-0002-8997-0630

person Samara Oliveira MOREIRA

schoolUniversidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Escola de Enfermagem Anna Nery. R. Afonso Cavalcante, 275, Cidade Nova, Rio de Janeiro, RJ, Brasil. CONTRIBUTORS MK ANJOS was responsible for the design and conception of the research project, for the collection, analysis and interpretation of data, and for writing this paper. TCSS OLIVEIRA and MB MOREIRA were responsible for data collection. SO MOREIRA was responsible for reviewing this study. MAC STIPP was responsible for writing and critical review. GO PAES was responsible for research guidance, writing and critical review.

0000-0003-0398-8045

person Marluci Andrade Conceição STIPP

schoolUniversidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Escola de Enfermagem Anna Nery. R. Afonso Cavalcante, 275, Cidade Nova, Rio de Janeiro, RJ, Brasil. CONTRIBUTORS MK ANJOS was responsible for the design and conception of the research project, for the collection, analysis and interpretation of data, and for writing this paper. TCSS OLIVEIRA and MB MOREIRA were responsible for data collection. SO MOREIRA was responsible for reviewing this study. MAC STIPP was responsible for writing and critical review. GO PAES was responsible for research guidance, writing and critical review.

0000-0002-9534-6324

person Graciele Oroski PAES

schoolUniversidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Escola de Enfermagem Anna Nery. R. Afonso Cavalcante, 275, Cidade Nova, Rio de Janeiro, RJ, Brasil. CONTRIBUTORS MK ANJOS was responsible for the design and conception of the research project, for the collection, analysis and interpretation of data, and for writing this paper. TCSS OLIVEIRA and MB MOREIRA were responsible for data collection. SO MOREIRA was responsible for reviewing this study. MAC STIPP was responsible for writing and critical review. GO PAES was responsible for research guidance, writing and critical review.

0000-0001-8814-5770

Correspondence to: MK ANJOS. E-mail: <
kirtonmatheus@gmail.com>.

CONTRIBUTORS

MK ANJOS was responsible for the design and conception of the research project, for the collection, analysis and interpretation of data, and for writing this paper. TCSS OLIVEIRA and MB MOREIRA were responsible for data collection. SO MOREIRA was responsible for reviewing this study. MAC STIPP was responsible for writing and critical review. GO PAES was responsible for research guidance, writing and critical review.

Pharmacology	Af	Rf
Capsules	11	002.3
Tablets*	452	093.6
Coated tablets	10	002.1
Drops	6	001.2
Solutions	1	000.2
Syrups	3	000.6
Total	483	100.0

Times of administration	Af	Rf
00:00 to 05:00	27	004.5
06:00 to 11:00*	253	041.7
12:00 to 17:00	127	021.0
18:00 to 23:00*	199	032.8
Total	606	100.0

Drug	Food/Nutrient	Mechanism/Effect	Potential interaction
Drug	Food/Nutrient	Mechanism/Effect	Af	Rf
Analgesic/Antipyretic
Dipyrone	Does not interact with food	__________*	0	00.0
Antiplatelet agent
Acetylsalicylic Acid (ASA)	Vitamin C and Vitamin K	Depletes vitamin absorption	34	13.5
Cilostazol	Rich in fats	Increases drug absorption	2	00.7
Antihypertensive
Anlodipine	Calcium, Potassium and Vitamin D	Depletes vitamin and mineral absorption	16	006.4
Atenolol	Food in general	May interfere with the plasma concentration of the drug	24	009.5
Atensine	Does not interact with food	__________*	0	000.0
Bisoprolol	Does not interact with food	__________*	0	000.0
Carvedilol	Food in general	Decreases gastrointestinal discomfort and orthostatic hypotension	22	008.7
Captopril	Food in general	Decreases drug absorption	12	004.8
Clonidine	Does not interact with food	__________*	0	000.0
Diltiazem	Food in general	Promotes drug absorption	3	001.2
Doxazosin (Carduran)	Does not interact with food	__________	0	00.0
Enalapril	Does not interact significantly with food	__________	0	00.0
Spironolactone	Food in general	Promotes drug absorption and retains potassium	21	08.3
Furosemide	Food in general	Decreases drug absorption	16	006.4
Hydralazine	Does not interact significantly with food	__________*	0	000.0
Hydrochlorothiazide	Food in general	Increases drug absorption	19	07.5
Losartan	Does not interact significantly with food	__________*	0	000.0
Metoprolol	Does not interact significantly with food	__________*	___*	__*
Nifedipine	Food in general (mainly grapefruit)	Increases the drug action time	1	000.4
Valsartana (Brasart)	Does not interact significantly with food	__________*	0	000.0
Antiarrhythmic
Amiodarone	Food in general (mainly grapefruit)	Increases drug bioavailability	9	003.6
Digoxin	High-fiber foods	Decreases absorption and peak serum concentration	6	002.4
Anticoagulant
Warfarin	Vitamin K-rich foods	Decreases anticoagulation	18	007.1
Antilipemic
Simvastatin	Grapefruit	Decreases drug bioavailability
Atorvastatin	Does not interact significantly with food	__________*	0	000.0
Antithrombotic
Clopidogrel	Does not interact with food	__________*	0	000.0
Antiulcer
Omeprazole	Vitamin B₁₂ and iron	Decreases absorption of Iron and Vitamin B₁₂	33	013.1
Ranitidine	Vitamin B₁₂ and iron	Decreases absorption of Iron and Vitamin B₁₂	7	002.8
Coronary vasodilator
Isosorbide monitrate	Food in general	Decreases drug absorption	9	003.6
Propatilnitrate (Substrate)	There are no studies demonstrating interactions with food	__________*	___*
Total of possible interactions			252	100.0

[1] Note:

[TFN01] ^*
Higher Tablet frequency.

[3] Af: Absolute Frequency; Rf: Relative frequency - %.

Potential drug-food interactions in patients hospitalized in the Cardiology Unit

Potenciais interações fármaco-alimento em pacientes internados no Setor de Cardiologia

ABSTRACT