The aim of this study was to evaluate in situ the effectiveness of a dentifrice containing monofluorophosphate (MFP) and dicalcium phosphate dihydrate (DCPD). Eight volunteers took part in this crossover, double blind design study performed in two phases of 45 days. The subjects were acrylic resin appliances containing four blocks of human dental enamel with artificial caries to evaluate fluoride uptake and remineralization by MFP/DCPD and Placebo dentifrices. After each phase the blocks of enamel were removed and the analysis of total fluoride (ppm F) and microhardness (Knoop) were evaluated. The results of total integrated areas under the curves of the two dentifrices treatments showed that the MFP/DCPD dentifrice produced a significantly higher fluoride uptake than the Placebo dentifrice (4508.55 <FONT FACE="Symbol">±</font> 965.82 and 1485.51 <FONT FACE="Symbol">±</font> 191.72, respectively) and the microhardness data demonstrated 34% and -14% of remineralization for MFP/DCPD and Placebo dentifrices, respectively. It was concluded that MFP/DCPD dentifrice was effective not only on fluoride uptake, but also on remineralization of artificial caries lesions of human dental enamel.
Fluoride; Tooth remineralization
