Resumo em Inglês:

ABSTRACT Background: Previous studies showed consistent results for associations between circulating concentrations of vitamin D and risk of antenatal, postnatal depression. Methods: Articles published in English before November 2020 were searched in databases as follows: PubMed, EMBASE, Web of Science, Medline, Google Scholar and Cochrane. These articles explored associations between circulating concentrations of vitamin D and risk of antenatal, postnatal depression.The present meta-analysis was conducted using STATA 12.0 software. Odds ratios (ORs) and 95% confidence intervals (CIs) extracted from included studies were computed using a random effects model or a fixed effects model according to heterogeneities between included studies. Q test and I2 were used to explore heterogeneities between included studies. Results: 7 cohort studies (including 1567 depression cases and 5254 controls) and 3 case-control studies (including 995 depression cases and 1265 controls) were included in the present study. The study showed that low circulating levels of 25-hydroxy (OH) vitamin D is significantly associated with a higher risk of antenatal and postnatal depression (OR = 1.02, 95% CI 1.01 to 1.04, I2 = 90.7%, p < 0.001). Conclusion: Our results have shown that the low level of vitamin D may be an adverse factor of antenatal and postnatal depression.

Resumo em Inglês:

ABSTRACT Objective: To investigate the associations between the depressive and anxiety levels and allergic rhinitis (AR) in children. Methods: Children less than 15 years old admitted to our hospital from April 2017 to December 2019 were enrolled in this study, including 692 AR children in the patient group and 713 normal individuals in the control group. The Screen for Child Anxiety Related Emotional Disorders (SCARED) was used to detect their depressive and anxiety levels, and the Middle Childhood Temperament Questionnaire (MCTQ) was used to evaluate their dominant affective temperaments. The comparisons of scale scores between these groups, and the correlation analysis between SCARED scores and MCTQ scores were conducted. Results: The mean SCARED scores of the patient group were significantly higher than the control group (P < 0.05). The patient group also had more AR children with the depressive temperament and anxious temperament than the control group (P<0.01). Strong correlations were found between the SCARED scores and MCTQ scores. Conclusion: The AR children had obvious depressive and anxious trends than non-allergic children. Screening the temperaments and detecting the depression and anxiety symptoms were imperative for AR children, especially for those with depression and anxious moods.

Resumo em Inglês:

ABSTRACT Objective: This study investigates the relationship between serum nitric oxide, asymmetrical dimethylarginine and symmetrical dimethylarginine levels and Total Antioxidant Capacity, and cognitive function in patients with bipolar disorder. Method: The study included 42 bipolar patients, diagnosed and assessed according to the DSM-V criteria, and 30 healthy controls. The Sociodemographic Questionnaire was used for the collection of data, and a bivariate Pearson correlation analysis was carried out. Results: The patient scores from a Rey Auditory Verbal Learning Test (RAVLT), Auditory Consonant Trigram (ACT), Digit Span Test (DST), Wisconsin Card Sorting Test (WCST), Trail Making-B (TMT-B) and Stroop Tests (ST) were found to be impaired in patients with BD when compared to the healthy controls. The SDMA level of the patient group was significantly higher in the control group, while the ADMA level was lower. The SDMA value was found to be positively correlated with ST-1,2,5 duration; and the NO value was positively correlated with ST-3 duration. Conclusions: The presence of neurobiological markers may serve to predict the severity of neurocognitive deficits, and can provide information about the progress of the disease.

Resumo em Inglês:

ABSTRACT Background: Burnout is observed when there is chronic exposure to work-related stress. This is commonly seen in physicians and undergraduate medical students. Thus, the study assessed and compared the severity of burnout among medical and dental senior undergraduate students in Abha, Saudi Arabia. Materials and method: 517 medical and dental senior undergraduate students were evaluated using a well-designed and formulated questionnaire. Different levels of burnout were evaluated with the related scores of burnout categories. Data collected was evaluated using SPSS version 25.0. Results: A total of 772 medical and dental senior undergraduate students were included in the study, out of which 517 responded to the questionnaire, with a response rate of t 67%. Demographic parameters like age, gender, marital status, and the course were assessed. The mean scores of Personal Accomplishment (PA), Emotional Exhaustion (EE), and Depersonalization (DP) for all study subjects were recorded, showing an insignificant difference (p-value > 0.05) between both the groups in all the three categories. Considering Personal Accomplishment, the lowest mean values were observed with subjects aged 23 years old, female participants, and unmarried students, with insignificant correlation, observed statistically. Conclusion: Moderate to high levels of burnout with no significant difference was observed between medical and dental students in all three burnout categories.

Resumo em Inglês:

ABSTRACT Background: Previous functional magnetic resonance imaging (fMRI) studies showed inconsistent results for comparison between bipolar disorder (BD) and healthy controls (HC). Methods: An anatomic likelihood estimation (ALE) meta-analysis was used to explore the key regions of brain pathology in BD with different current mood states. Results: Depressed BD patients showed reduced regional homogeneity (ReHo) in the left claustrum and the left middle frontal gyrus (MFG), compared to HC. BD patients with mixed mood status showed decreased fractional amplitude of low frequency fluctuations (fALFF) in the right cerebellar tonsil, the bilateral MFG and the right superior frontal gyrus, compared to HC. Additionally, BD patients with mixed mood status showed increased fALFF in the right inferior occipital gyrus, the right culmen and the left lentiform nucleus, compared to HC. BD patients with mixed mood status showed decreased functional connectivity (FC) in the bilateral cerebellar tonsil, compared to HC. Conclusion: In the present study, key regions undergoing functional deficits in BD patients with different current mood states were obtained with the ALE meta-analysis. In addition, deficits in these regions in fMRI studies might work as biomarkers for early diagnosis of BD.