|
Ng et al., 200488. Ng PC, Leung CW, Chiu WK, Wong SF, Hon EK. SARS in newborns and children. Biol Neonate. 2004;85:293-8. https://doi.org/10.1159/000078174 https://doi.org/https://doi.org/10.1159/...
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n=12 pregnant women infected with SARS-CoV. |
Review |
Four pregnant women died; two had a spontaneous miscarriage and termination of pregnancy; no newborn had SARS-CoV infection. |
Coronavirus is unlikely to be transmitted via the intrauterine route. |
Lau et al., 200499. Lau KK, Yu WC, Chu CM, Lau ST, Sheng B, Yuen KY. Possible central nervous system infection by SARS coronavirus. Emerg Infect Dis. 2004;10:342-4. https://doi.org/10.3201/eid1002.030638 https://doi.org/https://doi.org/10.3201/...
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n=1 32-year-old woman. |
Case report |
Incidence of generalized seizures with a positive RT-PCR for SARS-CoV in the cerebrospinal fluid. |
SARS-CoV can infect multiple organ systems, and CNS can possibly be affected. |
Yudin et al., 20051010. Yudin MH, Steele DM, Sgro MD, Read SE, Kopplin P, Gough KA. Severe acute respiratory syndrome in pregnancy. Obstet Gynecol. 2005;105:124-7. https://doi.org/10.1097/01.AOG.0000151598.49129.de https://doi.org/https://doi.org/10.1097/...
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n=1 33-year-old pregnant woman. |
Case report |
Labor occurred spontaneously at term, and a healthy female newborn was delivered. |
No evidence of perinatal transmission. |
Stockman et al., 20041111. Stockman LJ, Lowther SA, Coy K, Saw J, Parashar UD. SARS during pregnancy, United States. Emerg Infect Dis. 2004;10:1689-90. https://doi.org/10.3201/eid1009.040244 https://doi.org/https://doi.org/10.3201/...
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n=2 pregnant SARS case-patients. |
Letter |
Neither of the two pregnant women had severe negative outcomes. |
Few cases have been studied to define clearly the risks of pregnant women infected with SARS-CoV. |
Robertson et al., 20041212. Robertson CA, Lowther SA, Birch T, Tan C, Sorhage F, Stockman L, et al. SARS and pregnancy: a case report. Emerg Infect Dis. 2004;10:345-8. https://doi.org/10.3201/eid1002.030736 https://doi.org/https://doi.org/10.3201/...
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n=1 36-year-old pregnant woman. |
Case report |
Healthy female infant was delivered without complications. |
Long-term follow-up of infants is needed to characterize the pregnancy-related risks. |
Lam et al., 20041313. Lam CM, Wong SF, Leung TN, Chow KM, Yu WC, Wong TY, et al. A case-controlled study comparing clinical course and outcomes of pregnant and non-pregnant women with severe acute respiratory syndrome. BJOG. 2004;111:771-4. https://doi.org/10.1111/j.1471-0528.2004.00199.x https://doi.org/https://doi.org/10.1111/...
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n=10 pregnant and 40 non-pregnant female patients. |
Case-control |
Four required endotracheal intubations, and six were admitted to the intensive care unit (ICU). Three deaths in the pregnant group. |
Pregnant women with SARS experience a worse clinical course and poorer outcomes compared with non-pregnant women. |
Shek et al., 20031414. Shek CC, Ng PC, Fung GP, Cheng FW, Chan PK, Peiris MJ, et al. Infants born to mothers with severe acute respiratory syndrome. Pediatrics. 2003;112:e254. https://doi.org/10.1542/peds.112.4.e254 https://doi.org/https://doi.org/10.1542/...
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n=5 liveborn infants. |
Case series |
No manifestations or radiological, hematologic, or biochemical evidence suggestive of SARS. |
Newborns of mothers with SARS did not develop the disease. |
Li et al., 20051515. Li AM, Ng PC. Severe acute respiratory syndrome (SARS) in neonates and children. Arch Dis Child Fetal Neonatal Ed. 2005;90:F461-5. https://doi.org/10.1136/adc.2005.075309 https://doi.org/https://doi.org/10.1136/...
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n=12 pregnant women infected with SARS-CoV included in this review |
Review |
No evidence suggests that the virus is transmitted transplacentally. |
Vertical transmission of SARS-CoV from infected mothers to their newborns has not been observed. |