Associação entre padrão de sono e tratamento farmacológico em crianças com transtorno do déficit de atenção com hiperatividade: uma revisão sistemática

Rocha, Nathalia Sena; Correa, Rogério do Espírito Santo Amorim; Dias, Adria Carolina de Melo; Bueno, Cláudia Dizioli Franco

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Brasil

Revista Paulista de Pediatria

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Brasil

Español English

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Sumário

Review Article • Rev. paul. pediatr. 41 • 2023 • https://doi.org/10.1590/1984-0462/2023/41/2022065 copiar

Associação entre padrão de sono e tratamento farmacológico em crianças com transtorno do déficit de atenção com hiperatividade: uma revisão sistemática

Autoria SCIMAGO INSTITUTIONS RANKINGS

RESUMO

Objetivo:

Analisar a interferência do tratamento farmacológico no padrão de sono das crianças com transtorno do déficit de atenção com hiperatividade (TDAH).

Fontes de dados:

Busca eletrônica de alta sensibilidade nas bases de dados Cochrane Library, Medical Literature Analysis and Retrieval System Online (MEDLINE) via United States National Library of Medicine (PubMed), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) via Biblioteca Virtual em Saúde (BVS), Embase, Scopus, Cumulative Index to Nursing and Allied Health Literature (CINAHL) e Web of Science, de acordo com o preconizado pelo Cochrane Handbook, de artigos que passaram pela revisão por pares segundo o Guia PRESS.

Síntese dos dados:

Os estudos que contemplaram o uso das drogas atomoxetina (ATX), guanfacina, metilfenidato (MPH), dasotralina, L-teanina e lisdexanfetamina mostraram eficiência na redução dos sintomas do TDAH, embora todos os medicamentos, exceto a atomoxetina, tenham afetado a qualidade do sono — reduzindo REM total, fase não REM, tempo de sono de ondas lentas e maior latência de início do sono.

Conclusões:

Os fármacos utilizados no tratamento do TDAH costumam cursar com repercussões negativas sobre a qualidade do sono de crianças, e o fármaco atomoxetina demonstrou menores efeitos sobre essa variável.

Palavras-chave:
Transtorno do déficit de atenção com hiperatividade; Tratamento farmacológico; Sono

Authors and year of publication	Total population	Age (years)	Intervention drug	Intervention duration	Instrument
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Rugino¹¹11. Rugino TA. Effect on primary sleep disorders when children with ADHD are administered guanfacine extended release. J Atten Disord. 2018;22:14-24. https://doi.org/10.1177/1087054714554932 https://doi.org/10.1177/1087054714554932... , 2014	29	6–12	Guanfacine extended release (GXR)	5 weeks	Polysomnography and Children’s Sleep Habits Questionnaire
Ricketts et al.¹²12. Ricketts EJ, Sturm A, McMakin DA, McGuire JF, Tan PZ, Smalberg FB, et al. Changes in sleep problems across attention-deficit/hyperactivity disorder treatment: findings from the multimodal treatment of attention-deficit/hyperactivity disorder study. J Child Adolesc Psychopharmacol. 2018;28:690-8. https://doi.org/10.1089/cap.2018.0038 https://doi.org/10.1089/cap.2018.0038... , 2018	576	7–9	Methylphenidate	14 months	Achenbach Child Behavior Checklist 6-18
Goldman et al.¹⁸18. Goldman RS, Hopkins SC, Koblan KS, Pikalov AA, Hsu J, Mandel M, et al. Dasotraline in children with ADHD: effects on sleep habits as measured by the children’s sleep habits questionnaire. J Am Acad Child Adolesc Psychiatry. 2018;57:S179. https://doi.org/10.1016/j.jaac.2018.09.149 https://doi.org/10.1016/j.jaac.2018.09.1... , 2018	342	6–12	Dasotraline	6 weeks	Children’s Sleep Habits Questionnaire
Owens et al.¹³13. Owens J, Weiss M, Nordbrock C, Mattingly G, Wigal S, Greenhill LL, et al. Effect of aptensio XR (methylphenidate HCl extended-release) capsules on sleep in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2016;26:873-81. https://doi.org/10.1089/cap.2016.0083 https://doi.org/10.1089/cap.2016.0083... , 2016	256	Study 1: 6–12 Study 2: 6–18	Methylphenidate HCl extended-release capsules	16 weeks	Children’s or Adolescent Sleep Habits Questionnaire
Becker et al.¹⁷17. Becker SP, Froehlich TE, Epstein JN. Effects of methylphenidate on sleep functioning in children with attention-deficit/hyperactivity. J Dev Behav Pediatr. 2016;37:395-404. https://doi.org/10.1097/DBP.0000000000000285 https://doi.org/10.1097/DBP.000000000000... , 2016	163	7–11	Methylphenidate	4 weeks	Pittsburgh Side Effects Rating Scale
Stein et al.¹⁶16. Stein M, Garison M, Hart A, Newcorn J. Sleep problems in ADHD youth before and during treatment with methylphenidate and atomoxetine. 5th World Congress on ADHD: from child to adult disorder glasgow United Kingdom. 2015 may 28-31. United Kingdom p. 46-7., 2015	230	Uninformed	Methylphenidate and atomoxetine	3–7 weeks	A sleep assessment scale validated and completed by parents
Lyon et al.¹⁹19. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16:348-54. PMID: 22214254, 2011	93	8–12	L-Theanine chewable tablets	6 weeks	Pediatric Sleep Questionnaire and actigraphy
Solleveld et al.¹⁴14. Solleveld MM, Schrantee A, Baek HK, Bottelier MA, Tamminga HG, Bouziane C, et al. Effects of 16 weeks of methylphenidate treatment on actigraph-assessed sleep measures in medication-naive children with ADHD. Front Psychiatry. 2020;11:82. https://doi.org/10.3389/fpsyt.2020.00082 https://doi.org/10.3389/fpsyt.2020.00082... , 2020	50	10–12	Immediate-release methylphenidate	16 weeks	Actigraphy, Holland Sleep Disorder Questionnaire; Epworth Sleepiness Scale, and Evaluation List Insomnia Therapy
Ashkenasi¹⁵15. Ashkenasi A. Effect of transdermal methylphenidate wear times on sleep in children with attention deficit hyperactivity disorder. Pediatr Neurol. 2011;45:381-6. https://doi.org/10.1016/j.pediatrneurol.2011.09.003 https://doi.org/10.1016/j.pediatrneurol.... , 2011	26	6–12	Transdermal methylphenidate	4 weeks	Daily updated sleep diary
Giblin and Strobel²⁰20. Giblin JM, Strobel AL. Effect of lisdexamfetamine dimesylate on sleep in children with ADHD. J Atten Disord. 2011;15:491-8. https://doi.org/10.1177/1087054710371195 https://doi.org/10.1177/1087054710371195... , 2011	24	6–12	LDX administration	3 weeks	Polysomnography, actigraphy, and CSHQ

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[1] * Corresponding author. E-mail: nathalia.rocha@aluno.uepa.br (N. S. Rocha)