Delvin, 19861919. Delvin EE, Salle BL, Glorieux FH, Adeleine P, David LS. Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis. J Pediatr. 1986;109:328-34. https://doi.org/10.1016/s0022-3476(86)80396-1 https://doi.org/https://doi.org/10.1016/...
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RCT B n=40 |
25(OH)D, Ca, P and PTH |
|
[25(OH)D] of UC: IG 18 versus PG 7 ng/mL (p<0.001); [25(OH)D] (4 days): IG 13 versus PG 5 ng/mL (p<0.001); [Ca], [P] and UC [PTH], and 4 days: p>0.05 |
Yu, 20092020. Yu CK, Sykes L, Sethi M, Teoh TG, Robinson S. Vitamin D deficiency and supplementation during pregnancy. Clin Endocrinol (Oxf). 2009;70:685-90. https://doi.org/10.1111/j.1365-2265.2008.03403.x https://doi.org/https://doi.org/10.1111/...
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RCT n=180 |
25(OH)D |
|
[25(OH)D] of UC: IG2=26 versus IG1 25 versus PG 17 nmol/L (p=0.001) |
Roth, 20122121. Roth DE, Al Mahmud A, Raqib R, Black RE, Baqui AH. Pharmacokinetics of a single oral dose of vitamin D3 (70,000 IU) in pregnant and non-pregnant women. Nutr J. 2012;11:114. https://doi.org/10.1186/1475-2891-11-114 https://doi.org/https://doi.org/10.1186/...
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RCT n=27 |
25(OH)D |
-
IG: 1x 70,000 IU.
-
IT: GA 27-30 weeks
|
[25(OH)D] of UC and maternal (close to delivery): Pearson’s correlation =0.64 (p=0.02) |
Hashemipour, 20132222. Hashemipour S, Lalooha F, Zahir Mirdamadi S, Ziaee A, Dabaghi Ghaleh T. Effect of vitamin D administration in vitamin D-deficient pregnant women on maternal and neonatal serum calcium and vitamin D concentrations: a randomised clinical trial. Br J Nutr. 2013;110:1611-6. https://doi.org/10.1017/s0007114513001244 https://doi.org/https://doi.org/10.1017/...
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RCT O n=109 |
25(OH)D and Ca |
-
IG (<30 ng/mL): 8x 50,000 IU/week; PG: 400 IU/day+200 mg of Ca/day.
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IT: GA 24-26 weeks until delivery
|
|
Roth, 20132323. Roth DE, Al Mahmud A, Raqib R, Akhtar E, Black RE, Baqui AH. Pharmacokinetics of high-dose weekly oral vitamin D3 supplementation during the third trimester of pregnancy in Dhaka, Bangladesh. Nutrients. 2013;5:788-810. https://doi.org/10.3390/nu5030788 https://doi.org/https://doi.org/10.3390/...
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RCT n=28 |
25(OH)D |
-
IG1: 1x 70,000 IU+35,000 IU/week until delivery; IG2: 14,000 IU/week until delivery.
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IT: GA 27-30 for 10 weeks
|
|
Roth, 20122424. Roth DE, Mahmud AA, Raqib R, Baqui AH. Effects of high-dose antenatal 3rd-trimester vitamin D supplementation (35,000 IU/week) on maternal and newborn vitamin D status: a randomized placebo-controlled trial in Dhaka, Bangladesh. Faseb J. 2012;26 (Suppl 1):392-3. https://doi.org/10.1096/fasebj.26.1_supplement.392.3 https://doi.org/https://doi.org/10.1096/...
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RCT DB PC n=130 |
25(OH)D and Ca |
|
|
Shakiba, 20132525. Shakiba M, Iranmanesh MR. Vitamin D requirement in pregnancy to prevent deficiency in neonates: a randomised trial. Singapore Med J. 2013;54:285-8. https://doi.org/10.11622/smedj.2013110 https://doi.org/https://doi.org/10.11622...
|
RCT n=51 |
25(OH)D |
-
IG1: 50,000 IU/month; IG2: 50,000 IU every two weeks; IG3 4x 50,000 IU/week+50,000 IU/month.
-
IT: GA 13 weeks until delivery
|
|
Wagner, 20132626. Wagner CL, McNeil RB, Johnson DD, Hulsey TC, Robinson C, Hamilton SA, et al. Health characteristics and outcomes of two randomized vitamin D supplementation trials during pregnancy: a combined analysis. J Steroid Biochem Mol Biol. 2013;136:313-20. https://doi.org/10.1016/j.jsbmb.2013.01.002 https://doi.org/https://doi.org/10.1016/...
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RCT DB PC n=504 |
25(OH)D |
-
IG1: 2,000 IU/day; IG2: 4,000 IU/day; PG: 400 IU/day
-
IT: GA 16 weeks until delivery
|
-
% [25(OH)D] of UC ≥20 ng/mL: PG 39.2; IG1 58.2; IG2 76 (p<0.001)
-
[25(OH)D] of UC ≥32 ng/mL: PG 12.7%, IG1 15.2%, IG2 26% (p=0.020)
|
Dawodu, 20132727. Dawodu A, Saadi HF, Bekdache G, Javed Y, Altaye M, Hollis BW. Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency. J Clin Endocrinol Metab. 2013;98:2337-46. https://doi.org/10.1210/jc.2013-1154 https://doi.org/https://doi.org/10.1210/...
|
RCT n=162 |
25(OH)D |
-
PG: 400 IU/day; IG1: 2,000 IU/day; IG2: 4,000 IU/day
-
IT: GA 12-16 weeks until delivery
|
% [25(OH)D] ≥20 ng/mL UC: PG 9; IG1 18; IG2 34 (p<0.001) |
Mutlu, 20142828. Mutlu GY, Ozsu E, Kalaca S, Yuksel A, Pehlevan Y, Cizmecioglu F, et al. Evaluation of vitamin D supplementation doses during pregnancy in a population at high risk for deficiency. Horm Res Paediatr. 2014;81:402-8. https://doi.org/10.1159/000358833 https://doi.org/https://doi.org/10.1159/...
|
RCT n=91 |
25(OH)D |
-
IG1: 600 IU/day; IG2: 1,200 IU/day; IG3: 2,000 IU/day
-
IT: GA 13-32 weeks until delivery
|
|
Hossain, 20142929. Hossain N, Kanani FH, Ramzan S, Kausar R, Ayaz S, Khanani R, et al. Obstetric and neonatal outcomes of maternal vitamin D supplementation: results of an open-label, randomized controlled trial of antenatal vitamin D supplementation in Pakistani women. J Clin Endocrinol Metab. 2014;99:2448-55. https://doi.org/10.1210/jc.2013-3491 https://doi.org/https://doi.org/10.1210/...
|
RCT n=175 |
25(OH)D |
|
[25(OH)D]: IG 19.22 ng/dL; PG 6.27 ng/dL (p<0.05) |
Grant, 20143030. Grant CC, Stewart AW, Scragg R, Milne T, Rowden J, Ekeroma A, et al. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics. 2014;133:e143-53. https://doi.org/10.1542/peds.2013-2602 https://doi.org/https://doi.org/10.1542/...
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RCT DB PC n=260 |
25(OH)D |
-
IG1: 1,000 IU/day (mother)+400 IU/day (baby); IG2: 2,000 IU/day (mother)+800 IU/day (baby); PG
-
IT: GA 27 weeks until delivery and from birth until baby is six months old
|
|
Rodda, 20153131. Rodda CP, Benson JE, Vincent AJ, Whitehead CL, Polykov A, Vollenhoven B. Maternal vitamin D supplementation during pregnancy prevents vitamin D deficiency in the newborn: an open-label randomized controlled trial. Clin Endocrinol (Oxf). 2015;83:363-8. https://doi.org/10.1111/cen.12762 https://doi.org/https://doi.org/10.1111/...
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RCT O PC n=78 |
25(OH)D |
|
|
Sablok, 20153232. Sablok A, Batra A, Thariani K, Batra A, Bharti R, Aggarwal AR, et al. Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome. Clin Endocrinol (Oxf). 2015;83:536-41. https://doi.org/10.1111/cen.12751 https://doi.org/https://doi.org/10.1111/...
|
RCT DB PC n=180 |
25(OH)D |
IG (≥50 nmol/L): 1x 60,000 IU GA 20 weeks or (<50 nmol/L) 2-4x 120,000 IU/month start at 20 weeks; PG |
|
March, 20163333. March KM, Chen NN, Karakochuk CD, Shand AW, Innis SM, Dadelszen P, et al. Maternal vitamin D₃ supplementation at 50 µg/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk of age: a randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation. Am J Clin Nutr. 2015;102:402-10. https://doi.org/10.3945/ajcn.114.106385 https://doi.org/https://doi.org/10.3945/...
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RCT DB PC n=226 |
25(OH)D |
-
IG1: 400 IU/day; IG2: 1,000 IU/day; IG3: 2,000 IU/day; PG.
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IT: GA 13-24 weeks until 8 weeks
|
|
Wall, 20163434. Wall CR, Stewart AW, Camargo CA Jr, Scragg R, Mitchell EA, Ekeroma A, et al. Vitamin D activity of breast milk in women randomly assigned to vitamin D3 supplementation during pregnancy. Am J Clin Nutr. 2016;103:382-8. https://doi.org/10.3945/ajcn.115.114603 https://doi.org/https://doi.org/10.3945/...
|
RCT DB PC n=75 |
25(OH)D |
-
IG1: 1,000 IU/day; IG2: 2,000 IU/day; PG
-
IT: GA 27 weeks until delivery
|
[25(OH)D] UC: PG 44 nmol/L versus IG1 64 nmol/L versus IG2 78 nmol/L (p=0.002) |
Perumal, 20173535. Perumal N, Al Mahmud A, Baqui AH, Roth DE. Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh. Public Health Nutr. 2017;20:1865-73. https://doi.org/10.1017/s1368980015003092 https://doi.org/https://doi.org/10.1017/...
|
RCT n=160 |
25(OH)D |
|
[25(OH)D] <1 month: IG 80 nmol/L versus PG 22 nmol/L (p<0.01) |
Thiele, 20173636. Thiele DK, Ralph J, El-Masri M, Anderson CM. Vitamin D3 supplementation during pregnancy and lactation improves vitamin D status of the mother-infant dyad. J Obstet Gynecol Neonatal Nurs. 2017;46:135-47. https://doi.org/10.1016/j.jogn.2016.02.016 https://doi.org/https://doi.org/10.1016/...
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RCT DB n=13 |
25(OH)D |
|
|
Motamed, 20193737. Motamed S, Nikooyeh B, Kashanian M, Hollis BW, Neyestani TR. Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers, and maternal and neonatal outcomes. Matern Child Nutr. 2019;15:e12867. https://doi.org/10.1111/mcn.12867 https://doi.org/https://doi.org/10.1111/...
|
RCT O n=84 |
25(OH)D |
-
IG1: 1,000 IU/day; IG2: 2,000 IU/day
-
IT: GA 12 weeks until delivery
|
[25(OH)D]: IG1 24.0 nmol/L versus IG2 46.7 nmol/L (p=0.001) |
Enkhmaa, 20193838. Enkhmaa D, Tanz L, Ganmaa D, Enkhtur S, Oyun-Erdene B, Stuart J, et al. Randomized trial of three doses of vitamin D to reduce deficiency in pregnant Mongolian women. EBioMedicine. 2019;39:510-9. https://doi.org/10.1016/j.ebiom.2018.11.060 https://doi.org/https://doi.org/10.1016/...
|
RCT PC n=119 |
25(OH)D |
-
IG1: 600 IU/day; IG2: 2,000 IU/day; IG3: 4,000 IU/day
-
IT: GA 12-16 weeks until delivery
|
% [25(OH)D] UC >50 nmol/L: IG1 17, IG2 71, and IG3 80 (p<0.001) |