Delvin, 19861919. Delvin EE, Salle BL, Glorieux FH, Adeleine P, David LS. Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis. J Pediatr. 1986;109:328-34. https://doi.org/10.1016/s0022-3476(86)80396-1 https://doi.org/https://doi.org/10.1016/...
|
ECR C n=40 |
25(OH)D, Ca, P e PTH |
|
[25(OH)D] CU: GI 18 vs. GP 7 ng/mL (p<0,001); [25(OH)D] (4 dias): GI 13 vs. GP 5 ng/mL (p<0,001); [Ca], [P] e [PTH] CU e 4 dias: p>0,05 |
Yu, 20092020. Yu CK, Sykes L, Sethi M, Teoh TG, Robinson S. Vitamin D deficiency and supplementation during pregnancy. Clin Endocrinol (Oxf). 2009;70:685-90. https://doi.org/10.1111/j.1365-2265.2008.03403.x https://doi.org/https://doi.org/10.1111/...
|
ECR n=180 |
25(OH)D |
|
[25(OH)D] de CU: GI2=26 vs. GI1 25 vs. GP 17 nmol/L (p=0,001) |
Roth, 20122121. Roth DE, Al Mahmud A, Raqib R, Black RE, Baqui AH. Pharmacokinetics of a single oral dose of vitamin D3 (70,000 IU) in pregnant and non-pregnant women. Nutr J. 2012;11:114. https://doi.org/10.1186/1475-2891-11-114 https://doi.org/https://doi.org/10.1186/...
|
ECR n=27 |
25(OH)D |
-
GI: 1x 70.000 UI.
-
TI: IG 27-30 semanas
|
[25(OH)D] CU e materna (próximo do parto): coeficiente de Pearson=0,64 (p=0,02) |
Hashemipour, 20132222. Hashemipour S, Lalooha F, Zahir Mirdamadi S, Ziaee A, Dabaghi Ghaleh T. Effect of vitamin D administration in vitamin D-deficient pregnant women on maternal and neonatal serum calcium and vitamin D concentrations: a randomised clinical trial. Br J Nutr. 2013;110:1611-6. https://doi.org/10.1017/s0007114513001244 https://doi.org/https://doi.org/10.1017/...
|
ECR A n=109 |
25(OH)D e Ca |
|
-
[25(OH)D]: GI 27,7 vs. GP 9 ng/mL (p<0,01)
-
[Ca]: GI 99 vs. GP 91 mg/L (p<0,001)
|
Roth, 20132323. Roth DE, Al Mahmud A, Raqib R, Akhtar E, Black RE, Baqui AH. Pharmacokinetics of high-dose weekly oral vitamin D3 supplementation during the third trimester of pregnancy in Dhaka, Bangladesh. Nutrients. 2013;5:788-810. https://doi.org/10.3390/nu5030788 https://doi.org/https://doi.org/10.3390/...
|
ECR n=28 |
25(OH)D |
|
|
Roth, 20122424. Roth DE, Mahmud AA, Raqib R, Baqui AH. Effects of high-dose antenatal 3rd-trimester vitamin D supplementation (35,000 IU/week) on maternal and newborn vitamin D status: a randomized placebo-controlled trial in Dhaka, Bangladesh. Faseb J. 2012;26 (Suppl 1):392-3. https://doi.org/10.1096/fasebj.26.1_supplement.392.3 https://doi.org/https://doi.org/10.1096/...
|
ECR DC CP n=130 |
25(OH)D e Ca |
|
|
Shakiba, 20132525. Shakiba M, Iranmanesh MR. Vitamin D requirement in pregnancy to prevent deficiency in neonates: a randomised trial. Singapore Med J. 2013;54:285-8. https://doi.org/10.11622/smedj.2013110 https://doi.org/https://doi.org/10.11622...
|
ECR n=51 |
25(OH)D |
|
-
% [25(OH)D] CU >30 ng/mL: GI1 35; GI2 59; GI3 82 (p<0,01)
-
[25(OH)D] CU: GI1 25 ng/mL vs. GI2 32 ng/mL (p=0,03)
|
Wagner, 20132626. Wagner CL, McNeil RB, Johnson DD, Hulsey TC, Robinson C, Hamilton SA, et al. Health characteristics and outcomes of two randomized vitamin D supplementation trials during pregnancy: a combined analysis. J Steroid Biochem Mol Biol. 2013;136:313-20. https://doi.org/10.1016/j.jsbmb.2013.01.002 https://doi.org/https://doi.org/10.1016/...
|
ECR DC CP n=504 |
25(OH)D |
|
-
% [25(OH)D] CU ≥20 ng/mL: GP 39,2, GI1 58,2, GI2 76 (p<0,001)
-
[25(OH)D] CU ≥32 ng/mL: GP 12,7%, GI1 15,2%, GI2 26% (p=0,020)
|
Dawodu, 20132727. Dawodu A, Saadi HF, Bekdache G, Javed Y, Altaye M, Hollis BW. Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency. J Clin Endocrinol Metab. 2013;98:2337-46. https://doi.org/10.1210/jc.2013-1154 https://doi.org/https://doi.org/10.1210/...
|
ECR n=162 |
25(OH)D |
|
% [25(OH)D] ≥20 ng/mL CU: GP 9; GI1 18; GI2 34 (p<0,001) |
Mutlu, 20142828. Mutlu GY, Ozsu E, Kalaca S, Yuksel A, Pehlevan Y, Cizmecioglu F, et al. Evaluation of vitamin D supplementation doses during pregnancy in a population at high risk for deficiency. Horm Res Paediatr. 2014;81:402-8. https://doi.org/10.1159/000358833 https://doi.org/https://doi.org/10.1159/...
|
ECR n=91 |
25(OH)D |
|
-
[25(OH)D]: GI1 18,8 ng/mL; GI2 23,6 ng/mL; GI3 34 ng/mL (p=0,015)
-
% [25(OH)D] >30 ng/mL: GI1 36; GI2 52; GI3 92 (p=0,023)
|
Hossain, 20142929. Hossain N, Kanani FH, Ramzan S, Kausar R, Ayaz S, Khanani R, et al. Obstetric and neonatal outcomes of maternal vitamin D supplementation: results of an open-label, randomized controlled trial of antenatal vitamin D supplementation in Pakistani women. J Clin Endocrinol Metab. 2014;99:2448-55. https://doi.org/10.1210/jc.2013-3491 https://doi.org/https://doi.org/10.1210/...
|
ECR n=175 |
25(OH)D |
|
[25(OH)D]: GI 19,22 ng/dL; GP 6,27 ng/dL (p<0,05) |
Grant, 20143030. Grant CC, Stewart AW, Scragg R, Milne T, Rowden J, Ekeroma A, et al. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics. 2014;133:e143-53. https://doi.org/10.1542/peds.2013-2602 https://doi.org/https://doi.org/10.1542/...
|
ECR DC CP n=260 |
25(OH)D |
|
-
[25(OH)D] CU: GP 13 ng/mL; GI1 24 ng/mL; GI2 26 ng/mL (p<0,01)
-
6 meses: GP 31 ng/mL; GI1 34 ng/mL; GI2 38 ng/mL (p=0,004)
|
Rodda, 20153131. Rodda CP, Benson JE, Vincent AJ, Whitehead CL, Polykov A, Vollenhoven B. Maternal vitamin D supplementation during pregnancy prevents vitamin D deficiency in the newborn: an open-label randomized controlled trial. Clin Endocrinol (Oxf). 2015;83:363-8. https://doi.org/10.1111/cen.12762 https://doi.org/https://doi.org/10.1111/...
|
ECR A CP n=78 |
25(OH)D |
|
-
[25(OH)D] CU: GI: 81 nmol/L vs. GP: 42 nmol/L (p<0,01)
-
[25(OH)D] materna no parto e CU (coeficiente de Spearman: 0,880; p<0,0001)
|
Sablok, 20153232. Sablok A, Batra A, Thariani K, Batra A, Bharti R, Aggarwal AR, et al. Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome. Clin Endocrinol (Oxf). 2015;83:536-41. https://doi.org/10.1111/cen.12751 https://doi.org/https://doi.org/10.1111/...
|
ECR DC CP n=180 |
25(OH)D |
GI (≥50 nmol/L): 1x 60.000 UI IG 20 semanas ou (<50 nmol/L) 2-4x 120.000 UI/mês início 20 semanas; GP |
-
[25(OH)D] CU: GP 43,1 nmol/L vs. GI 56,8 nmol/L (p<0,001)
-
% [25(OH)D] >50 nmol/L: GP 14 vs. GI 46,2 (p<0,001)
|
March, 20163333. March KM, Chen NN, Karakochuk CD, Shand AW, Innis SM, Dadelszen P, et al. Maternal vitamin D₃ supplementation at 50 µg/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk of age: a randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation. Am J Clin Nutr. 2015;102:402-10. https://doi.org/10.3945/ajcn.114.106385 https://doi.org/https://doi.org/10.3945/...
|
ECR DC CP n=226 |
25(OH)D |
|
-
[25(OH)D] (8 semanas): GI1 69 nmol/L vs. GI2 78 nmol/L vs. GI3 88 nmol/L (p<0,05)
-
[25(OH)D] >30 nmol/L (8 semanas): GI3 ∼98%
|
Wall, 20163434. Wall CR, Stewart AW, Camargo CA Jr, Scragg R, Mitchell EA, Ekeroma A, et al. Vitamin D activity of breast milk in women randomly assigned to vitamin D3 supplementation during pregnancy. Am J Clin Nutr. 2016;103:382-8. https://doi.org/10.3945/ajcn.115.114603 https://doi.org/https://doi.org/10.3945/...
|
ECR DC CP n=75 |
25(OH)D |
|
[25(OH)D] CU: GP 44 nmol/L vs. GI1 64 nmol/L vs. GI2 78 nmol/L (p=0.002) |
Perumal, 20173535. Perumal N, Al Mahmud A, Baqui AH, Roth DE. Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh. Public Health Nutr. 2017;20:1865-73. https://doi.org/10.1017/s1368980015003092 https://doi.org/https://doi.org/10.1017/...
|
ECR n=160 |
25(OH)D |
|
[25(OH)D] <1 mês: GI 80 nmol/L vs. GP 22 nmol/L (p<0,01) |
Thiele, 20173636. Thiele DK, Ralph J, El-Masri M, Anderson CM. Vitamin D3 supplementation during pregnancy and lactation improves vitamin D status of the mother-infant dyad. J Obstet Gynecol Neonatal Nurs. 2017;46:135-47. https://doi.org/10.1016/j.jogn.2016.02.016 https://doi.org/https://doi.org/10.1016/...
|
ECR DC n=13 |
25(OH)D |
|
-
[25(OH)D] CU: G2 23,4 nmol/L vs.GI 32,6 ng/mL (p=0,017)
-
[25(OH)D] 4-6 semanas+AME: G2 17,0 nmol/L vs. GI 24,9 ng/mL (p=0,256)
|
Motamed, 20193737. Motamed S, Nikooyeh B, Kashanian M, Hollis BW, Neyestani TR. Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers, and maternal and neonatal outcomes. Matern Child Nutr. 2019;15:e12867. https://doi.org/10.1111/mcn.12867 https://doi.org/https://doi.org/10.1111/...
|
ECR A n=84 |
25(OH)D |
|
[25(OH)D]: GI1 24,0 nmol/L vs. GI2 46,7 nmol/L (p=0,001) |
Enkhmaa, 20193838. Enkhmaa D, Tanz L, Ganmaa D, Enkhtur S, Oyun-Erdene B, Stuart J, et al. Randomized trial of three doses of vitamin D to reduce deficiency in pregnant Mongolian women. EBioMedicine. 2019;39:510-9. https://doi.org/10.1016/j.ebiom.2018.11.060 https://doi.org/https://doi.org/10.1016/...
|
ECR CP n=119 |
25(OH)D |
|
% [25(OH)D] CU >50 nmol/L: GI1 17, GI2 71 e GI3 80 (p<0,001) |