Cost-utility analysis of interferon-free treatments for patients with early-stage genotype 1 hepatitis C virus in Brazil

Abstract

INTRODUCTION

We conducted a cost-utility analysis of available interferon-free treatments for patients with early-stage genotype 1 chronic hepatitis C based on a Brazilian public health system perspective.

METHODS

A Markov model was derived using a cohort of stage F0-F2 patients treated as recommended by the Brazilian national guidelines.

RESULTS:

Glecaprevir plus pibrentasvir was superior to all other treatments, followed by sofosbuvir plus velpatasvir. Sofosbuvir plus daclatasvir was identified as the least cost-effective option.

CONCLUSIONS:

The above findings were confirmed via probabilistic sensitivity analysis and the tested scenarios.

Keywords:
Hepatitis C; Cost-effectiveness analysis; Treatment; Brazil