Atrial flutter complicating severe leptospirosis : a case report

Cardiac disturbances are relatively common and electrocardiographic abnormalities may be found in more than 70% of patients with leptospirosis. We report the case of a 68 year-old male with severe leptospirosis who developed atrial flutter. Effective treatment was done with amiodarone. The patient became clinical stable, with complete recovery. Rigorous clinical observation and continuous electrocardiogram (ECG) monitoring may facilitate the identification of rhythm disorders, and thus prevent a probable fatal outcome, in severe cases of leptospirosis.

Leptospirosis is a zoonotic disease of global distribution associated with a diverse clinical spectrum.It is caused by species of Leptospira, and transmitted to humans by direct contact with infected tissues or contaminated urine, or indirectly by contact with contaminated water or soil.Mammalian reservoirs are the main distributors, and although rodents are the most important reservoir, other animals, including livestock, wild and domestic animals may excrete leptospires in their urine and, therefore, be a potential source of infection [1][2][3] .Leptospirosis is associated with occupational and recreational exposure, usually occurring as endemic in rural areas with outbreaks associated with floods 1,3 .
Clinical spectrum is broad in leptospirosis.Multiple clinical presentations may occur and a wide variety of diseases may mimic different stages of leptospirosis 1 .Most patients will present a febrile self-limited condition, often misdiagnosed as influenza or dengue 1,2,4 .Severe manifestations occur in approximately 5-10% of human infections and are characterized by the presence of jaundice, acute renal failure and hemorrhagic disorders, including severe pulmonary hemorrhage syndrome 1,2,5 .In severe forms the biphasic presentation becomes more evident.The first phase is commonly referred as septicemic; it lasts for 5 to 7 days and high fever, myalgia, headache, conjunctival suffusion, abdominal pain and vomiting are usually seen during this period.A brief afebrile period may follow this phase just before the immune phase of the disease begins.The latter is characterized by multiorgan involvement and a higher mortality rate 2,3,5,6 .
Less common presentations may occur in a significant number of cases and lead to misdiagnosis.Pulmonary involvement may range from clinically undetectable to massive hemoptysis and respiratory failure, with severe pulmonary forms present in up to 74% of lethal cases, representing the main cause of death in Brazil 2,5 .Neurological manifestations such as symptomatic aseptic meningitis, myeloradiculopathy and myelopathy may be found in case-reports throughout the literature 4 .Pancreatitits is a rare complication, however asymptomatic hyperamylasemia is often present 2,4 .Cardiac disturbances are quite common and electrocardiographic abnormalities may be found in more than 70% of patients; nonetheless cardiac life-threatening conditions are unusual 7,8 .In recent study in Sri Lanka, during an outbreak in 2008, myocarditis was reported in 7.1% of cases and heart failure in 3.9% 9 .
The objective of this article is to report a case of severe leptospirosis complicated by the occurrence of atrial flutter, an uncommon arrhythmia in the course of the disease.
A 68 year-old male agriculturist was brought by family members to the emergency department with a history of high fever (39°C, 40°C) that had started 10 days earlier.Two days after the initial symptom, the patient presented with the onset of diffuse myalgia, which was worst on abdomen and inferior limbs, shortness of breath, oliguria and bilateral conjuctival hemorrhage.Family members noted a deteriorating clinical condition and brought the patient, on the fifth day of the disease, to a previous hospital, where the patient was initially diagnosed with severe Dengue.Over the following days, there was persistence of the fever, onset of jaundice and continuous deterioration of the patient's condition, being than transferred to this hospital.His past medical history was unremarkable except  for transurethral resection e subtotal prostatectomy for benign prostatic hypertrophy four years ago.Upon admission the patient presented with a reduced consciousness, with a Glascow Coma Scale of 13 (verbal response: 6; ocular response: 3; motor response: 4), febrile to the touch, severe conjunctival hemorrhage in both eyes, taquicardic but with normal cardiac auscultation, breath sounds were unremarkable, liver and spleen were not palpable at the abdomen examination and bowel sound were present, severe tenderness of abdominal, thigh and calf muscles, painful even to superficial palpation and bilateral and symmetrical edema of inferior limbs.
His initial blood work, related to the eighth day of the disease, showed a hemoglobin of 13.2mg/dL, a white blood cell count of 12,900/mm 3 , with 67% of neutrophils and 23% of lymphocytes, platelets of 42,500/mm 3 , a creatinin level of 6.0mg/dL, an aspartate aminotransferase of 80U/L, an alanine aminotransferase of 76U/L, with 2.0g/dL of albumin and creatine phosphokinase (CPK) of 89 U/L.Total bilirubin was 7.3mg/dL with a direct bilirubin of 6.82mg/dL and amylase was 221U/L.Kidney function continued to decrease over the next days, with blood urea level of 214mg/dL, creatinine of 7.2mg/dL, a metabolic acidosis (pH of 7.26, pCO 2 of 31 and HCO 3 -of 14.6) and hyperkalemia of 6.0mEq/L.
Upon admission to this hospital, intravenous ceftriaxone as initiated along with supportive measures, including vigorous hydration, to which there was rapid response with diuresis.On the tenth day of the disease a central venous catheter was obtained for emergency hemodialysis.The day after the patient's pulse rate increased to 180/min and an electrocardiogram revealed an atrial flutter, with abnormal F waves (Figure 1), a 2:1 atrium-ventricular block and an atrial frequence of 360/min.The patient showed no signs of hemodynamic instability; his blood pressure maintained at a baseline level of 110 over 90mmHg, there was no worsening of his consciousness level, no acute onset of dyspnea or precordial pain.An attack dose of amiodarone was then administered and reverted the atrial flutter to a sinus tachycardia with a pulse rate of 120/min.The patient was transferred to an intensive care unit bed for further monitoring.
He remained in the intensive care unit (ICU) for four days.During that period he remained performing daily hemodialysis, he showed no newer arrhythmias or hemodynamic instability and his consciousness level improved.Bilirubin and CPK levels increased initially as well as his white blood count (WBC) count.Cardiac involvement is usually subclinical, in milder forms, or masked by pulmonary hemorrhage, in severe leptospirosis 8 .Most of the reports have been clinical and tachycardia, electrocardiogram (ECG) abnormalities and refractory hypotension are the usual clinical manifestations 1,[10][11][12] .Pericardial effusion has been reported in patients with leptospirosis and advanced renal failure, suggesting a possible role for uremia in such patients 12 .
The mechanism of cardiac involvement is poorly elucidated but may, as for kidney damage, result from toxic mechanisms associated with endotoxins, immunoallergic phenomena or direct damage by leptospira 1 .Disseminated intravascular coagulation can also play an important role in leptospirosis-associated cardiac involvement 9 .Autopsy studies have shown a high prevalence of cardiac involvement in severe leptospirosis, with up to 96% of patients dying from such disease 8,11 .The autopsy findings are many; cardiomegaly, pericardic hemorrhage, perivascular inflammation, endocarditis and intimitis of coronary arteries and of the aorta were among the features of cardiac damage 8,11 .The predominant histophatological finding was an interstitial myocarditis, present in up to 96% of the studies mentioned and highly associated with inflammation of the conduction system 8,11 .
Electrocardiographic abnormalities may be found in numerous patients undergoing hospitalization for leptospirosis treatment.Some series report these changes in 48% to 80% of patients 7,8,10 .These results are probably overestimated since most Silva FTM et al -Atrial flutter in leptospirosis

FIGURE 1 -
FIGURE 1 -Abnormal F waves with a 2:1 atrium-ventricular block and an atrial frequence of 360/min.