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Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum

Abstract

INTRODUCTION:

Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp.

METHODS:

In order to determine mutations associated with benzimidazole resistance in Ascaris suum, worms were collected from slaughtered pigs and a partial region of the β-tubulin gene was sequenced.

RESULTS:

All parasites showed the wildtype genotype for codons 167, 198, and 200 of the β-tubulin gene.

CONCLUSIONS:

This is the first report of genetic sequences associated with benzimidazole resistance in A. suum.

Keywords:
Ascaris suum; Benzimidazole; Beta-tubulin gene

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