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Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity

Abstracts

It has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. T-cell immune response was assessed by means of intradermal tests using recall antigens in a group of 22 patients with hepatosplenic schistosomiasis, one year after treatment with oxamniquine and compared with a group of untreated hepatosplenic patients. Only 27% of treated patients presented complete anergy to all tested antigens, in marked contrast to 80% unresponsiveness showed by hepatosplenic patients without treatment. Although most of the treated individuals showed some response to the tested antigens, in some individuals this unresponsiveness still persisted after treatment. Anergy was not found in any normal individual of the control group. It was concluded that Schistosoma mansoni infected patients may recover their normal immune responsiveness after the elimination of the worm by treatment

Immunodepression; Schistosomiasis; Oxamniquine


Tem sido observado que infecção por Schistosoma mansoni pode causar imunodepressão celular. Neste trabalho foi avaliado se a imunodepressão associada à esquistossomose pode ser revertida pelo tratamento especifico. A resposta imune celular foi determinada através de testes cutâneos de hipersensibilidade retardada em 22 pacientes com a forma hepatoesplênica da esquistossomose um ano após tratamento com oxamniquine e comparado com aquela observada em um grupo de pacientes hepatoesplênicos não tratados. Somente 27% destes pacientes apresentaram alergia a todos os antígenos testados, em contraste com 80% de indivíduos anêrgicos observados entre aqueles não tratados. Embora a maioria dos indivíduos tratados tenha mostrado algum grau de resposta aos antígenos testados, alguns indivíduos permaneceram anérgicos após o tratamento específico. Anergia a todos os antígenos aplicados não foi observada em nenhum dos indivíduos normais. Nossos dados indicam que pacientes esquistossomóticos podem recuperar sua reatividade imune após a eliminação do verme pelo tratamento específico.

Imunodepressão; Esquistossomose; Oxamniquine


ARTICLES

Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity

Maria Imaculada Muniz-Junqueira; José Tavares-Neto; Meire Ataide; Aluizio Prata; Carlos Eduardo Tosta

Adress to correspondence Adress to correspondence: Dr a Maria Imaculada Muniz- Junqueira Laboratório de Imunologia Departamento de Patologia/FCS/UnB. 70910 Brasília, DF, Brasil.

ABSTRACT

It has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. T-cell immune response was assessed by means of intradermal tests using recall antigens in a group of 22 patients with hepatosplenic schistosomiasis, one year after treatment with oxamniquine and compared with a group of untreated hepatosplenic patients. Only 27% of treated patients presented complete anergy to all tested antigens, in marked contrast to 80% unresponsiveness showed by hepatosplenic patients without treatment. Although most of the treated individuals showed some response to the tested antigens, in some individuals this unresponsiveness still persisted after treatment. Anergy was not found in any normal individual of the control group. It was concluded that Schistosoma mansoni infected patients may recover their normal immune responsiveness after the elimination of the worm by treatment

Keywords: Immunodepression. Schistosomiasis. Oxamniquine.

RESUMO

Tem sido observado que infecção por Schistosoma mansoni pode causar imunodepressão celular. Neste trabalho foi avaliado se a imunodepressão associada à esquistossomose pode ser revertida pelo tratamento especifico. A resposta imune celular foi determinada através de testes cutâneos de hipersensibilidade retardada em 22 pacientes com a forma hepatoesplênica da esquistossomose um ano após tratamento com oxamniquine e comparado com aquela observada em um grupo de pacientes hepatoesplênicos não tratados. Somente 27% destes pacientes apresentaram alergia a todos os antígenos testados, em contraste com 80% de indivíduos anêrgicos observados entre aqueles não tratados. Embora a maioria dos indivíduos tratados tenha mostrado algum grau de resposta aos antígenos testados, alguns indivíduos permaneceram anérgicos após o tratamento específico. Anergia a todos os antígenos aplicados não foi observada em nenhum dos indivíduos normais. Nossos dados indicam que pacientes esquistossomóticos podem recuperar sua reatividade imune após a eliminação do verme pelo tratamento específico.

Palavras-chave: Imunodepressão. Esquistossomose. Oxamniquine.

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Recebido para publicação em 22/01/91.

Núcleo de Medicina Tropical e Nutrição e Laboratório de Imunologia Celular, Faculdade de Ciências da Saúde, Universidade de Brasilia, Brasília, DF. Faculdade, de Medicina do Triângulo Mineiro, Uberaba, MG.

Grants: CNPq (Proc. 40.1041/PIDE VI and 40.1868/87).

  • 1. Abdel-Salam E, Higashi GI, Kamal KA, Ishaac S. Cell- mediated immune assay in children with Schistosoma haematobium infection and the effect of niridazole therapy. Transactions of the Royal Society of Tropical Medicine and Hygiene 75: 207-214, 1981.
  • 2. Andrade ZA, Grimaud JA. Evolution of the schistosomal hepatic lesions in mice after curative chemotherapy. American Journal of Pathology 124:59-65,1986.
  • 3. Andrade ZA, Warren KS. Mild prolonged schistosomiasis in mice: alterations in host response with time and the development of portal fibrosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 5 8:53- 57, 1964.
  • 4. Barsoum IS, Gamil FM, Al-Khafif MA, Ramzy RM, El Alamy MA, Colley DG. Immune responses and immunoregulation in relation to human schistosomiasis in Egypt I. Effect of treatment on in vitro cellular responsiveness. The American Journal of Tropical Medicine and Hygiene 31: 1181-1187, 1982.
  • 5. Bina JC, Prata A. Regressão da hepatotosplenomegalia pelo tratamento especifico da esquistossomose. Revista da Sociedade Brasileira de Medicina Tropical 16: 213- 218, 1983.
  • 6. Boros DL, Pelley RP, Warren KS. Spontaneous modulation of granulomatous hypersensitivity in Schistosomiasis mansoni Journal of Immunology 114: 1437- 1441, 1975.
  • 7. Butterworth AE, Capron M, Cordingley JS, Dalton PR, Dunne DW, Kariuki HC, Kimani G, Koech D, Mugambi M. Ouma JH, Prentice MA, Richardson BA, Arap Siongok TK, Sturrock RF, Taylor DW. Immunity after treatment of human Schistosomiasis mansoni II. Identification of resistant individuals, and analysis of their immune responses. Transactions of the Royal Society of Tropical Medicine and Hygiene 79: 393-408, 1985.
  • 8. Cheever AW, Deb S. Persistence of hepatic fibrosis and tissue eggs following treatment of Schistosoma japonicum infected mice. The American Journal of Tropical Medicine and Hygiene 40: 620-628, 1989.
  • 9. Colley DG, Todd CW, Lewis FA, Goodgame R W. Immune responses during human Schistosomiasis mansoni VI in vitro nonspecific suppression of phytohemagglutinin responsiveness induced by exposure to certain schistosomal preparations. Journal of Immunology 122: 1447-1453, 1979.
  • 10. Cottrell BJ, Humber D, Sturrock RF, Seitz H, Rees P. Non-specific cell mediated immunity in patients infected with Schistosoma mansoni in Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene 76: 234-237, 1982.
  • 11. Coutinho AD, Antunes MTA, Domingues ALC. Estudo da imunidade humoral e celular na doença hepática esquistossomótica. Revista do Instituto de Medicina Tropical de São Paulo 24: 282-291, 1982.
  • 12. Gutteridge F. Human experimentation and medical ethics international guidelines for biomedical research involving human subjects. World Health Organization Chronicle 35: 212-215, 1981.
  • 13. Hahn H, Kauftnann SHE. The role of cell-mediated immunity in bacterial infections. Reviews of Infectious Diseases 3: 1221-1250, 1981.
  • 14. Katz N, Chaves A, Pellegrino J. A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni Revista do Instituto de Medicina Tropical de São Paulo 14: 397-400, 1972.
  • 15. Kumada M, Hosaka Y, Kawabata M, Asahi H, KatoK, Kobayakawa T, Hayashi S. Recovery from immunesupression in mice infected with Schistosoma japonicum by treatment of praziquantel. Japanese Journal of Medical Science and Biology 40: 89-93, 1987.
  • 16. Mota-Santos TA, Tavares CAP, Gazzinelli G, Pellegrino J. Immunosuppression mediated by adult worms in chronic Schistosomiasis mansoni The American Journal of Tropical Medicine and Hygiene 26: 727-731, 1977.
  • 17. Muniz-Junqueira MI. Resposta imune e atividade de macrófagos para Salmonella na esquistossomose mansoni. Tese de Mestrado, Universidade de Brasilia, Brasilia, 1987.
  • 18. Muniz-Junqueira MI, Tosta CE, Prata A. T cell-dependent immunodepression in vivo in Schistosoma mansoni-infected patients. Revista da Sociedade Brasileira de Medicina Tropical 23: 27-31, 1990.
  • 19. Prata A. Como caracteriza a forma hepato-esplênica da esquistossomose? In: II Simpósio sobre Esquistossomose, Salvador p. 179, 1970.
  • 20. Rosen FS, Wedgwood RJ, Eibl M. Primary immunodeficiency diseases. Clinical Immunology and Immunopathology 40: 166-196, 1986.
  • 21. Tawfik AF, Carter CE, Colley DG. Effects of antischistosomal chemotherapy on immune responses, protection and immunity. I Changes in cellular and humoral responses. The American Journal of Tropical Medicine and Hygiene 35: 100-109, 1986.
  • 22. Teixeira RS. Associação de infecção por S. mansoni e bacteremia prolongada por enterobactérias. In: Aspectos peculiares da infecção por S. mansoni CEDRE, Universidade Federal da Bahia p. 35-102, 1984.
  • Adress to correspondence:

    Dr
    a Maria Imaculada Muniz- Junqueira
    Laboratório de Imunologia
    Departamento de Patologia/FCS/UnB.
    70910
    Brasília, DF, Brasil.
  • Publication Dates

    • Publication in this collection
      15 May 2013
    • Date of issue
      June 1991

    History

    • Accepted
      22 Jan 1991
    • Received
      22 Jan 1991
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