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Short Communication • Rev. Soc. Bras. Med. Trop. 52 • 2019 • https://doi.org/10.1590/0037-8682-0001-2018   copy

Stress conditions in the host induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival.

METHODS:

Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host.

RESULTS:

Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture.

CONCLUSIONS:

These findings highlight the role of host stress in the virulence of S. epidermidis.

Keywords:
Persistence; Starvation; Virulence

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