Bestetti/200099. Bestetti R. Stroke in a hospital-derived cohort of patients with chronic Chagas' disease. Acta Cardiol. 2000;55(1):33-8. |
79 |
1 fatal stroke |
Mild to moderate heart failure |
Prevalence of stroke is low in a hospital-derived cohort of patients |
Aras/20031717. Aras R, da Matta JA, Mota G, Gomes I, Melo A. Cerebral infarction in autopsies of chagasic patients with heart failure. Arq Bras Cardiol . 2003;81(4):414-6. |
524 autopsies |
92 with encephalic infarction |
Patients who died from heart failure |
Cerebral infarction was associated with death in 52% of the cases |
Oliveira-Filho/200566. Oliveira-Filho J, Viana LC, Vieira-de-Melo RM, Faical F, Torreao JA, Villar FA, et al. Chagas disease is an independent risk factor for stroke: baseline characteristics of a Chagas Disease cohort. Stroke. 2005;36(9):2015-7. |
305 |
32 |
Cardiomyopathy |
Systolic dysfunction, presence of cardiac arrhythmias, cardioversion, and diabetes are predictors of stroke |
Carod-Artal/20052525. Jesus PA, Neville I, Cincurá C, Menezes DF, Vieira-de-Melo RM, Lacerda AM, et al. Stroke history and Chagas disease are independent predictors of silent cerebral microembolism in patients with congestive heart failure. Cerebrovasc Dis. 2011;31(1):19-23. |
478 with stroke |
94 Chagas with stroke |
Indeterminate form and heart disease |
Apical aneurysm, heart failure, arrhythmia, female, and hypertension are predictors of stroke |
Paixao/20091414. Paixao LC, Ribeiro AL, Valacio RA, Teixeira AL. Chagas disease: independent risk factor for stroke. Stroke. 2009;40(12):3691-4. |
101 with stroke |
101 |
Indeterminate form and heart disease |
Previous stroke/transient ischemic attack history, atrial fibrillation, and CD-positive serology are associated with stroke |
Nunes/20091111. Nunes MC, Barbosa MM, Ribeiro AL, Barbosa FB, Rocha MO. Ischemic cerebrovascular events in patients with Chagas cardiomyopathy: a prospective follow-up study. J Neurol Sci. 2009;278(1-2):96-101. |
213 |
39 |
Heart failure with LV systolic dysfunction |
Left ventricular systolic dysfunction and left atrial volume enlargement are independent risk factors for stroke |
Jesus/20112424. Leon-Sarmiento FE, Mendoza E, Torres-Hillera M, Pinto N, Prada A J, Silva CA, et al. Trypanosoma cruzi-associated cerebrovascular disease: a case-control study in Eastern Colombia. J Neurol Sci . 2004;217(1):61-4. |
144 (62 with Chagas disease) |
9 |
Heart failure |
Chagas disease and stroke history are risk factors for microembolism |
Dias Junior/201477. Dias Junior JO, da Costa Rocha MO, de Souza AC, Kreuser LJ, de Souza Dias LA, Tan TC, et al. Assessment of the source of ischemic cerebrovascular events in patients with Chagas disease. Int J Cardiol. 2014;176(3):1352-4. |
52 with Chagas disease |
26 |
Indeterminate form and heart disease |
Apical aneurysms and intracavitary thrombi |
Nunes/201544. Nunes MC, Kreuser LJ, Ribeiro AL, Sousa GR, Costa HS, Botoni FA, et al. Prevalence and risk factors of embolic cerebrovascular events associated with Chagas heart disease. Global heart. 2015;10(3):151-7. |
330 |
67 |
Chagas cardiomyoapthy |
Apical aneurysm and left ventricular thrombus |
Guedes/20164242. Guedes PM, de Andrade CM, Nunes DF, de Sena Pereira N, Queiroga TB, Machado-Coelho GL, et al. Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients. PLoS Negl Trop Dis. 2016;10(4):e0004669. |
65 |
35 |
Indeterminate form, heart disease and cardiodigestive |
Thromboembolic events, imbalanced. Expression of IL-10, FoxP3, and iNOS are associated with higher stroke and death risks |
Montanaro/20164545. Montanaro VV, da Silva CM, de Viana Santos CV, Lima MI, Negrão EM, de Freitas GR. Ischemic stroke classification and risk of embolism in patients with Chagas disease. J Neurol. 2016;263(12):2411-5. |
86 with Chagas and stroke |
86 |
Patients with Chagas disease hospitalized with stroke |
The FIOCRUZ score did not predict cardiomebolic stroke etiologies |
Montanaro/20184343. Montanaro VVA, Hora TF, da Silva CM, Santos CVV, Lima MIR, Negrao EM, et al. Mortality and Stroke Recurrence in a Rehabilitation Cohort of Patients with Cerebral Infarcts and Chagas Disease. Eur J Neurol. 2018;79(3-4):177-84. |
279 |
279 |
Indeterminate form and heart disease |
Age at stroke, initial modified Rankin Scale, bladder dysfunction, diabetes, and alcoholism are associated with mortality after stroke. |
Cerqueira-Silva/20212121. Cerqueira-Silva T, Goncalves BM, Pereira CB, Porto LM, Marques ME, Santos LS, et al. Chagas disease is an independent predictor of stroke and death in a cohort of heart failure patients. Int J Stroke. 2022;17(2):180-8. |
565 (271 with Chagas disease) |
16 with stroke during follow-up |
Heart failure |
Chagas disease is associated with increased risk of stroke and death independently of heart failure severity or cardiac arrhythmias |
Montanaro/20214444. Montanaro VVA, Hora TF, Guerra AA, Silva GS, Bezerra RP, Oliveira-Filho J, et al. Artificial Inteligence-Based Decision for the Prediction of Cardioembolism in Patients with Chagas Disease and Ischemic St roke . J Stroke Cerebrovasc Dis . 2021;30(10):106034. |
499 |
499 |
Patients with Chagas disease and stroke in several academic, hospital-based, and university hospitals across Brazil |
Higher prevalence of vascular risk factors and lower median age in patients with cardioembolic etiology |