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Short Communications • Rev. Soc. Bras. Med. Trop. 48 (2) • mar-apr 2015 • https://doi.org/10.1590/0037-8682-0198-2014   copy

Production of metallo-β-lactamase among Pseudomonas aeruginosa strains isolated in the State of Sergipe, Brazil

Authorship SCIMAGO INSTITUTIONS RANKINGS

INTRODUCTION:

Acquired production of metallo-β-lactamases is an important mechanism of resistance in Pseudomonas aeruginosa. The objective of this study was to investigate the production of metallo-β-lactamase and the genetic diversity among ceftazidime-resistant P. aeruginosa isolates from State of Sergipe, Brazil.

METHODS:

Metallo-β-lactamase was investigated using the disk approximation test and polymerase chain reaction (PCR). Genetic diversity was evaluated by pulsed-field gel electrophoresis (PFGE).

RESULTS:

A total of 48 (51.6%) isolates were resistant to ceftazidime. Six (12.2%) of these were positive for metallo-β-lactamase production. Only two (4.1%) of the ceftazidime-resistant isolates carried the bla SPM-1 gene.

CONCLUSIONS:

Production of metallo-β-lactamases was not the main mechanism of resistance to ceftazidime and carbapenems among P. aeruginosa strains in Sergipe, Brazil.

Pseudomonas aeruginosa; Antimicrobial resistance; Metallo-β-lactamase

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