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Alterações quantitativas das células neuroendócrinas no Megacólon chagásico

Resumos

Utilizando-se técnicas histoquímicas pela prata (Masson-Fontana e Sevier- Munger) estudaram-se a distribuição e o número de células enterocromafins (EC) e do conjunto EC mais células argirófilas (ARG) em peças cirúrgicas de megassigmóide chagásico. Observou-se que tanto nos "megas"(n = 16) como nos controles (n = 8), a posição das células EC e ARG na mucosa foi predominantemente basal, com distribuição irregular, principalmente das EC. A análise histológica revelou aparente aumento numérico das EC e do conjunto EC mais ARG. Todavia, contagens sistematizadas mostraram que somente o conjunto dessas células apresentou aumento estatisticamente significativo (P < 0,01). Realizou-se também o estudo morfométrico da mucosa e das musculares que revelou espessamento significativo (P

Megacólon chagásico; Células enterocromafins; Células argirófilas; Células neuroendócrinas


Silver stainings (Masson-Fontana and Sevier- Munger methods) were applied to sections from surgical specimens of chagasic megasigmoid. The distribution and the number of both enterochromaffin (EC) cells and EC plus argyrophyl (ARG) cells were studied. Both of them, EC and ARG cells presented a predominantly basal localization in mucosal glands of megasigmoids (n = 16) and Controls (n= 8) The counting of EC cells and EC plus ARG cells has shown that only the group EC plus ARG cells was significantly increased. Morphometric studies revealed a significant increase in the thickness of the muscle and mucosa layers of the megasigmoid when compared to the Controls.

Chagasic megacolon; Enterochromaffin cells; Argyrophyl cells; Neuroendocrine cells


ARTIGOS

Alterações quantitativas das células neuroendócrinas no Megacólon chagásico* * Trabalho realizado no Departamento de Anatomia Patológica e Medicina Legal da Faculdade de Medicina da Universidade Federal de Minas Gerais. Av. Alfredo Balena 190, 30.000, Belo Horizonte, MG. Brasil. Auxilio financeiro: CNPq(Proc. nP 30.1851/76) e FINEP (Proc. n o 43/83/0119/00).

Alfredo J.A. Barbosa; Nivaldo H. Toppa; José R. Cunha Melo; Washington L. Tafuri

RESUMO

Utilizando-se técnicas histoquímicas pela prata (Masson-Fontana e Sevier- Munger) estudaram-se a distribuição e o número de células enterocromafins (EC) e do conjunto EC mais células argirófilas (ARG) em peças cirúrgicas de megassigmóide chagásico. Observou-se que tanto nos "megas"(n = 16) como nos controles (n = 8), a posição das células EC e ARG na mucosa foi predominantemente basal, com distribuição irregular, principalmente das EC. A análise histológica revelou aparente aumento numérico das EC e do conjunto EC mais ARG. Todavia, contagens sistematizadas mostraram que somente o conjunto dessas células apresentou aumento estatisticamente significativo (P < 0,01). Realizou-se também o estudo morfométrico da mucosa e das musculares que revelou espessamento significativo (P <0,01) dessas camadas em relação aos casos controles.

Palavras-chave: Megacólon chagásico. Células enterocromafins. Células argirófilas. Células neuroendócrinas.

ABSTRACT

Silver stainings (Masson-Fontana and Sevier- Munger methods) were applied to sections from surgical specimens of chagasic megasigmoid. The distribution and the number of both enterochromaffin (EC) cells and EC plus argyrophyl (ARG) cells were studied. Both of them, EC and ARG cells presented a predominantly basal localization in mucosal glands of megasigmoids (n = 16) and Controls (n= 8) The counting of EC cells and EC plus ARG cells has shown that only the group EC plus ARG cells was significantly increased. Morphometric studies revealed a significant increase in the thickness of the muscle and mucosa layers of the megasigmoid when compared to the Controls.

Keywords: Chagasic megacolon. Enterochromaffin cells. Argyrophyl cells. Neuroendocrine cells.

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Recebido para publicação em 7/12/84.

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  • *
    Trabalho realizado no Departamento de Anatomia Patológica e Medicina Legal da Faculdade de Medicina da Universidade Federal de Minas Gerais. Av. Alfredo Balena 190, 30.000, Belo Horizonte, MG. Brasil.
    Auxilio financeiro: CNPq(Proc. nP 30.1851/76) e FINEP (Proc. n
    o 43/83/0119/00).
  • Datas de Publicação

    • Publicação nesta coleção
      07 Jun 2013
    • Data do Fascículo
      Dez 1985

    Histórico

    • Recebido
      07 Dez 1984
    • Aceito
      07 Dez 1984
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