A study on the fortuitons advantage of gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion

Lúcia Maria Almeida Braz Vicente Amato Neto Fábio Luís Carignani Andréia Otaviani Di Pietro Fernandes Nelson Hamerschlak Laura Santoro Zuanella Maria de Fátima dos Santos Silva Iolanda Lima de Souza Massayuki Okumura About the authors

This study was carried out to evaluate the fortuitons advantage of using gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion, with mice as the experimental model. In the first step, when the infected blood with Plasmodium berghei was submitted to 2,500rad and 5,000rad, with or without metronidazol, there was no success, because the animals presented parasitaemia and died after inoculation of irradiated blood. However, there was partial success in the second step, when the infected blood received 10,000 and 15,000rad, and was inoculated in mice, which showed infection, and presented a survival rate of 20% and 40%, respectively, with later negativation of blood infected by P. berghei.

Blood transfusion; Malaria prophylaxis; Gamma irradiation; Plasmodium berghei


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