Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

Oliveira, Saulo Gomes de; Souza, Ilana Brito Ferraz de; Constantino, Taynan da Silva; Silva, Paula Carolina Valença; Lima, Elker Lene Santos de; Muniz, Maria Tereza Cartaxo; Domingues, Ana Lúcia Coutinho

doi:10.1590/0037-8682-0145-2020

Acessibilidade / Reportar erro

Brasil

Revista da Sociedade Brasileira de Medicina Tropical

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Short Communication • Rev. Soc. Bras. Med. Trop. 54 • 2021 • https://doi.org/10.1590/0037-8682-0145-2020 copy

Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.

METHODS:

This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.

RESULTS:

A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.

CONCLUSIONS:

This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.

Keywords:
Schistosomiasis; Periportal ﬁbrosis; Mannose-binding lectin

Regression of the periportal fibrosis pattern
	Yes (n = 21)		No (n = 85)
Characteristics	n	%	n	%	RR	CI 95%	p-value
Sex
Female	12	57	44	52	1	(reference)
Male	9	43	41	48	0.958	[0.793 - 1.157]	0.421
Total	21	100	85	100
HDA
No	15	71	43	51	1	(reference)
Yes	6	29	42	49	2.069	[0.870 - 4.919]	0.070
Total	21	100	85	100
Treatment for HDA
Not treated	14	67	39	46	1	(reference)
Treated	7	33	46	54	0.847	[0.699- 1.027]	0.071
Total	21	100	85	100
Current contact with focus area
No	20	95	78	92	1	(reference)
Yes	1	5	7	8	0.909	[0.687 - 1.204]	0.468
Total	21	100	85	100
Contact with focus area after treatment
No	17	81	73	86	1	(reference)
Yes	4	19	12	14	1.081	[0.801 - 1.459]	0.411
Total	21	100	85	100
Structural region (Exon 1) MBL
AA	11	52	62	73	1	(reference)
AO/OO	10	48	23	27	2.450	[1.200 - 4.990]	0.015
Total	21	100	85	100
Promoter region -221 MBL ^a
YY	16	84	59	73	1	(reference)
XX/XY	3	16	22	27	0.893	[0.741 - 1.077]	0.230
Total	19	100	81	100
Promoter region -550 MBL ^a
LL	6	32	29	36	1	(reference)
HL/HH	13	68	52	64	1.035	[0.853 - 1.257]	0.468
Total	19	100	81	100
MBL haplotypes ^a
(LYO/LXO;LYO/LYO;HYA/LXO)
High expression	8	42	42	52	1	(reference)
(HYA/LYA)
Intermediate expression	9	47	34	42	1.062	[0.873 - 1.291]	0.365
Low expression	2	11	5	6	1.176	[0.724 - 1.907]	0.386
(LYA/LYO;HYA/LYO;HYA/LXA)
Total	19	100	81	100

Sociedade Brasileira de Medicina Tropical - SBMT Caixa Postal 118, 38001-970 Uberaba MG Brazil, Tel.: +55 34 3318-5255 / +55 34 3318-5636/ +55 34 3318-5287, http://rsbmt.org.br/ - Uberaba - MG - Brazil
E-mail: rsbmt@uftm.edu.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Corresponding author: PhD. Ana Lúcia Coutinho Domingues. e-mail:alcdomingues@hotmail.com