In lepers hopitalised at a sanatory in Bairibui, State of Minas Gerais (Brazil), endemic area of Chagas' disease. 38.63% of positive serological tests for American Trypanosomiasis were found. Both groups of positive and negative patients were examined from a clinical, electrocardiographic and radiologic point of view. The data were compared to others of the region, suggesting that the sulphonamid treatment, in these cases, did not change the positivness of "Guerreiro & Machado" reaction. Apparently neither does the leprotic process interfere with the evolution of Chagas' disease, nor does the latter interfere with the former. Clinical findings of non chagasic group permit one to foresee the possibilities of cardiovascular consequences in leprosy, not yet well limited and with few searchs in Medical Literature.