Neurodevelopment in the third year of life in children with antenatal ZIKV-exposure

Carolina Yuri Panvequio Aizawa Deyse Mayara Rodrigues Caron Carolina Barbosa de Souza Paula Fernanda Augusto Kozima Luana Damasceno Christa Einspieler Peter B. Marschik Patrícia Brasil Ana Carolina Basso Schmitt Karin Nielsen-Saines Renata Hydee Hasue About the authors

ABSTRACT

We report cognitive, language and motor neurodevelopment, assessed by the Bayley-III test, in 31 non-microcephalic children at age 3 with PCR-confirmed maternal Zika virus exposure (Rio de Janeiro, 2015–2016). Most children had average neurodevelopmental scores, however, 8 children (26%) presented delay in some domain. Language was the most affected: 7 children (22.6%) had a delay in this domain (2 presenting severe delay). Moderate delay was detected in the cognitive (3.2%) and motor (10%) domains. Maternal illness in the third trimester of pregnancy and later gestational age at birth were associated with higher Bayley-III scores. Zika-exposed children require long-term follow-up until school age.

DESCRIPTORS:
Child Development; Language Development; Cognition; Motor Activity; Zika Virus

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