Seventy male patients with acute gonorrhea with 3.0 g of Ampicillin K in a single oral dose were treated. Discharge disappeared in 87.1% of cases, in an average of 24-72 hours (clinical cure). Three cases (4.3%) showed a light mucous hialine discharge with no N. gonorrhoeae (bacteriological cure). Urethral discharge persisted in 6 patients (8.6%) with N. gonorhoeae in smears and culture (Failure). Clinical and/or bacteriological cure were observed in 64 patients (91.4%).