Alldred et al.1616. Alldred DP, Kennedy MC, Hughes C, Chen TF, Miller P. Interventions to optimise prescribing for older people in care homes. Cochrane Database Syst Rev. 2016;(2):CD009095. https://doi.org/10.1002/14651858.CD009095.pub3
https://doi.org/10.1002/14651858.CD00909...
(2016) |
Randomized controlled clinical trial |
12 |
Educational Interventions Medication review Computerized systems |
Long-term care unit |
8/11 |
Castelino et al.1919. Castelino RL, Bajorek BV, Chen TF. Targeting suboptimal prescribing in the elderly: a review of the impact of pharmacy services. Ann Pharmacother. 2009;43(6):1096-106. https://doi.org/10.1345/aph.1L700
https://doi.org/10.1345/aph.1L700...
(2009) |
Randomized controlled clinical trial |
12 |
Pharmaceutical intervention Medication review |
Hospital |
5/11 |
Cooper et al.22. Cooper JA, Cadogan CA, Patterson SM, Kerse N, Bradley MC, Ryan C, et al. Interventions to improve the appropriate use of polypharmacy in older people: a Cochrane systematic review. BMJ Open. 2015;5(12):e009235. https://doi.org/10.1136/bmjopen-2015-009235
https://doi.org/10.1136/bmjopen-2015-009...
(2015) |
Randomized controlled clinical trial |
12 |
Pharmaceutical intervention Medication review |
Hospital |
9/11 |
Forsetlund et al.55. Forsetlund L, Eike MC, Gjerberg E, Vist GE. Effect of interventions to reduce potentially inappropriate use of drugs in nursing homes: a systematic review of randomised controlled trials. BMC Geriatr. 2011;11:16. https://doi.org/10.1186/1471-2318-11-16
https://doi.org/10.1186/1471-2318-11-16...
(2011) |
Randomized controlled clinical trial |
20 |
Educational Intervention Medication review |
Nursing home |
7/11 |
Gutierrez Valencia et al.77. Gutierrez Valencia M, Martinez Velilla N, Lacalle Fabo E, Beobide Telleria I, Larrayoz Sola B, Tosato M. Intervenciones para optimizar el tratamiento farmacológico en ancianos hospitalizados: una revisión sistemática. Rev Clin Esp. 2016;216(4):205-21. https://doi.org/10.1016/j.rce.2016.01.005
https://doi.org/10.1016/j.rce.2016.01.00...
(2016) |
Prospective studies (not necessarily controlled and randomized) with interventions |
18 |
Pharmaceutical interventions Educational Interventions Computerized systems Medication review |
Hospital |
7/11 |
Iankowitz et al.4646. Iankowitz N, Dowden M, Palomino S, Uzokwe H, Worral P. The effectiveness of computer system tools on potentially inappropriate medications ordered at discharge for adults older than 65 years of age: a systematic review. JBI Libr Syst Rev. 2012;10(13):798-831. https://doi.org/10.11124/jbisrir-2012-68
https://doi.org/10.11124/jbisrir-2012-68...
(2015) |
Randomized controlled clinical trial, quasi-experimental study |
5 |
Computerized systems |
Hospital |
9/11 |
Johansson et al.2727. Johansson T, Abuzahra ME, Keller S, Mann E, Faller B, Sommerauer C, et al. Impact of strategies to reduce polypharmacy on clinically relevant endpoints: a systematic review and meta-analysis. Br J Clin Pharmacol. 2016;82(2):532-48. https://doi.org/10.1111/bcp.12959
https://doi.org/10.1111/bcp.12959...
(2016) |
Randomized controlled clinical trial, randomized controlled trial, non-randomized controlled clinical trial, cohort study, case-control study |
25 |
Pharmaceutical interventions Medication review |
Hospital |
3/11 |
Kaur et al.2020. Kaur S, Mitchell G, Vitetta L, Roberts MS. Interventions that can reduce inappropriate prescribing in the elderly: a systematic review. Drugs Aging. 2009;26(12):1013-28. https://doi.org/10.2165/11318890-000000000-00000
https://doi.org/10.2165/11318890-0000000...
(2009) |
Randomized controlled clinical trial, prospective study, cohort study, survey, retrospective and prospective case series |
24 |
Pharmaceutical interventions Educational Interventions Computerized systems Medication review Other interventions |
Hospital |
6/11 |
Loganathan et al.2828. Loganathan M, Singh S, Franklin BD, Bottle A, Majeed A. Interventions to optimise prescribing in care homes: systematic review. Age Ageing. 2011;40(2):150-62. https://doi.org/10.1093/ageing/afq161
https://doi.org/10.1093/ageing/afq161...
(2011) |
Randomized controlled clinical trial and non-randomized controlled clinical trial |
16 |
Pharmaceutical interventions Educational Interventions Computerized systems Medication review |
Nursing home |
8/11 |
Loh et al.2929. Loh ZW, Cheen MH, Wee HL. Humanistic and economic outcomes of pharmacist-provided medication review in the community-dwelling elderly: a systematic review and meta-analysis. J Clin Pharm Ther. 2016;41(6):621-33. https://doi.org/10.1111/jcpt.12453
https://doi.org/10.1111/jcpt.12453...
(2016) |
Randomized controlled clinical trial |
25 |
Medication review |
Community |
3/11 |
Maeda2424. Maeda K. Systematic review of the effects of improvement of prescription to reduce the number of medications in the elderly with polypharmacy. Yakugaku Zasshi. 2009;129(5):631-45. https://doi.org/10.1248/yakushi.129.631
https://doi.org/10.1248/yakushi.129.631...
(2009) |
Randomized controlled trials, controlled clinical trials |
28 |
Medication review |
Community Hospital Nursing home |
5/11 |
Marasinghe4545. Marasinghe KM. Computerised clinical decision support systems to improve medication safety in long-term care homes: a systematic review. BMJ Open. 2015;5(5):e006539. https://doi.org/10.1136/bmjopen-2014-006539
https://doi.org/10.1136/bmjopen-2014-006...
(2015) |
Randomized controlled clinical trial, cohort studies, retrospective and prospective studies |
7 |
Computerized systems |
Long-term care unit |
6/11 |
Michelazzo et al.2121. Michelazzo MB, Milovanovic S, Boccia S. A systematic review of case-series studies on the effectiveness of interventions to reduce polypharmacy and its adverse consequences in the elderly. Epidemiol Biostat Public Health. 2017;14(1). https://doi.org/10.2427/12148
https://doi.org/10.2427/12148...
(2017) |
Case series |
19 |
Pharmaceutical intervention Educational Intervention Medication review |
Hospital Community Nursing home |
3/11 |
Olaniyan et al.4747. Olaniyan JO, Ghaleb M, Dhillon S, Robinson P. Safety of medication use in primary care. Int J Pharm Pract. 2015;23(1):3-20. https://doi.org/10.1111/ijpp.12120
https://doi.org/10.1111/ijpp.12120...
(2015) |
Retrospective non-randomized study, Retrospective randomized study |
68 |
Pharmaceutical intervention Computerized systems |
Primary care |
9/11 |
Page et al.5252. Page AT, Clifford RM, Potter K, Schwartz D, Etherton-Beer CD. The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta-analysis. Br J Clin Pharmacol. 2016;82(3):583-623. https://doi.org/10.1111/bcp.12975
https://doi.org/10.1111/bcp.12975...
(2016) |
Randomized controlled clinical trial |
116 |
Other interventions |
Hospital |
10/11 |
Patterson et al.1717. Patterson SM, Cadogan CA, Kerse N, Cardwell CR, Bradley MC, Ryan C, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2014(10):CD008165. https://doi.org/10.1002/14651858.CD008165.pub3
https://doi.org/10.1002/14651858.CD00816...
(2014) |
Randomized controlled clinical trial, non-randomized controlled clinical trials, controlled before-after studies, interrupted time series |
10 |
Pharmaceutical interventions Computerized systems |
Hospital |
7/11 |
Riordan et al.2222. Riordan DO, Walsh KA, Galvin R, Sinnott C, Kearney PM, Byrne S. The effect of pharmacist-led interventions in optimising prescribing in older adults in primary care: a systematic review. SAGE Open Med. 2016;4:2050312116652568. https://doi.org/10.1177/2050312116652568
https://doi.org/10.1177/2050312116652568...
(2016) |
Randomized controlled clinical trial, quasi-randomized controlled clinical trial, controlled before-after studies, interrupted time series |
5 |
Pharmaceutical interventions Medication review |
Primary care |
3/11 |
Rollason e Vogt2525. Rollason V, Vogt N. Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist. Drugs Aging. 2003;20(11):817-32. https://doi.org/10.2165/00002512-200320110-00003
https://doi.org/10.2165/00002512-2003201...
(2003) |
Randomized controlled clinical trial |
14 |
Pharmaceutical interventions Medication review |
Hospital |
3/11 |
Shade et al.4848. Shade MY, Berger AM, Chaperon C. Potentially inappropriate medications in community-dwelling older adults. Res Gerontol Nurs. 2014;7(4):178-92. https://doi.org/10.3928/19404921-20140210-01
https://doi.org/10.3928/19404921-2014021...
(2014) |
Randomized controlled clinical trial and non-randomized clinical trial |
67 |
Computerized systems |
Community |
7/11 |
Thiruchelvam et al.2323. Thiruchelvam K, Hasan SS, Wong PS, Kairuz T. Residential aged care medication review to improve the quality of medication use: a systematic review. J Am Med Dir Assoc. 2017;18(1):87.e1-87.e14. https://doi.org/10.1016/j.jamda.2016.10.004
https://doi.org/10.1016/j.jamda.2016.10....
(2017) |
Randomized controlled clinical trial and observational studies |
22 |
Medication review |
Hospital |
5/11 |
Tjia et al.3333. Tjia J, Velten SJ, Parsons C, Valluri S, Briesacher BA. Studies to reduce unnecessary medication use in frail older adults: a systematic review. Drugs Aging. 2013;30(5):285-307. https://doi.org/10.1007/s40266-013-0064-1
https://doi.org/10.1007/s40266-013-0064-...
(2013) |
Randomized controlled clinical trial and non-randomized clinical trial, before-after studies, case series |
36 |
Medication review |
Hospital Nursing home |
3/11 |
Verrue et al.3030. Verrue CL, Petrovic M, Mehuys E, Remon JP, Vander Stichele R. Pharmacists’ interventions for optimization of medication use in nursing homes: a systematic review. Drugs Aging. 2009;26(1):37-49. https://doi.org/10.2165/0002512-200926010-00003
https://doi.org/10.2165/0002512-20092601...
(2009) |
Controlled trials (randomized or non-randomized) |
8 |
Pharmaceutical interventions Medication review |
Nursing home |
3/11 |
Walsh et al.3535. Walsh K, O’Riordan D, Kearney PM, Timmons S, Byrne S. Improving the appropriateness of prescribing in older patients: a systematic review and meta-analysis of pharmacists’ interventions in secondary care. Age Ageing. 2016;45(2):201-9. https://doi.org/10.1093/ageing/afv190
https://doi.org/10.1093/ageing/afv190...
(2016) |
Controlled trials (randomized or non-randomized) |
4 |
Pharmaceutical interventions Medication review |
Hospital |
7/11 |
Yourman et al.5050. Yourman L, Concato J, Agostini JV. Use of computer decision support interventions to improve medication prescribing in older adults: a systematic review. Am J Geriatr Pharmacother. 2008;6(2):119-29. https://doi.org/10.1016/j.amjopharm.2008.06.001
https://doi.org/10.1016/j.amjopharm.2008...
(2008) |
Randomized controlled clinical trial |
10 |
Computerized systems |
Hospital |
3/11 |