Bladder and colon |
Cohort |
20,646 |
IA and NC, USA |
Koutros et al. (2009)7272 Koutros S, Lynch CF, Ma X, et al. Aromatic amine pesticide use and human cancer risk: results from the U.S. Agricultural Health Study. Int J Cancer. 2009; 124(5):1206-1212.
|
Bladder |
Cohort |
54,344 |
IA and NC, USA |
Koutros et al. (2016)7373 Koutros S, Silverman DT, Alavanja MCR, et al. Occupational exposure to pesticides and bladder cancer risk. Int J Epidemiol. 2016; 45(3):792-805.
|
Bladder
|
Cohort |
148,051 |
France |
Boulanger et al. (2017)7474 Boulanger M, Tual S, Lemarchand C, et al. Agricultural exposure and risk of bladder cancer in the AGRIculture and CANcer cohort. Int Arch Occup Environ Heal. 2017; 90(2):169-178.
|
Brain |
Case-control |
2,040 cases + 4,140 controls |
RJ, Brazil |
Miranda-Filho et al. (2012)6565 Miranda Filho AL, Monteiro GTR, Meyer A. Brain cancer mortality among farm workers of the State of Rio de Janeiro, Brazil: A population-based case-control study, 1996-2005. Int. j. hyg. environ. health. 2012; 215(5):496-501.
|
Brain |
Cohort |
7,734 |
RJ, Brazil |
Miranda Filho et al. (2014)6666 Miranda Filho AL, Koifman RJ, Koifman S, et al. Brain cancer mortality in an agricultural and a metropolitan region of Rio de Janeiro, Brazil: a population-based, age-period-cohort study, 1996-2010. BMC cancer. 2014; 14(320):1-9.
|
Breast
|
Case-control |
207 cases + 621 controls |
Canada |
Ashley-Martin et al. (2012)7070 Ashley-Martin J, Vanleeuwen J, Cribb A. Breast cancer risk, fungicide exposure and cyp1a1*2a gene-environment interactions in a province-wide case control study in prince edward island, Canada. Int. j. environ. res. public health. 2012; 9(5):1846-1858.
|
Cervical |
Case-control |
33 cases +132 controls |
Wuhan, China |
Zhang et al. (2013)6969 Zhang B, Zhou AF, Zhu C-C, et al. Risk Factors for Cervical Cancer in Rural Areas of Wuhan China: a Matched Case-control Study. Asian pac. j. cancer prev. 2013; 14(12):7595-7600.
|
Cholangio carcinoma
|
Case-control |
210 cases + 840 controls |
Thailand |
Jeephet et al. (2016)6363 Jeephet K, Kamsa-Ard S, Bhudhisawasdi V, et al. Association between pesticide use and cholangiocarcinoma. Asian pac. J. cancer prev. 2016; 17(8):3977-3980.
|
CNS
|
Cohort |
181,842 |
France |
Piel et al. (2017)6464 Piel C, Pouchieu C, Tual S, et al. Central nervous system tumors and agricultural exposures in the prospective cohort AGRICAN. Int. j. cancer. 2017; 141(9):1771-1782.
|
Colon |
Cohort |
25,712 |
IA and NC, USA |
Kang et al. (2008)5757 Kang D, Park SK, Beane-Freeman L, et al. Cancer incidence among pesticide applicators exposed to trifluralin in the Agricultural Health Study. Environ. res. 2008; 107(2):271-276.
|
Colon and breast |
Cohort |
39,628 men + 28,319 women |
IA and NC, USA |
Andreotti et al. (2010)5858 Andreotti G, Hou L, Freeman LEB, et al. Body Mass Index, Agricultural Pesticide Use, and Cancer Incidence in the Agricultural Health Study Cohort. Cancer causes control. 2010; 21(11):1759-1775.
|
Colorretal |
Case-control |
421 cases + 439 controls |
Egypt |
Lo et al. (2010)5656 Lo A-C, Soliman AS, Khaled HM, et al. Lifestyle, occupational, and reproductive factors and risk of colorectar cancer. Dis. colon rectum. 2010; 53(5):830-837.
|
Cutaneous melanoma |
Case-control |
150 cases + 24,554 controls |
IA and NC, USA |
Dennis et al. (2010)7777 Dennis LK, Lynch CF, Sandler DP, et al. Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study. Environ health perspect. 2010; 118(6):812-817.
|
Esophagus |
Case-control |
5,782 cases + 5,782 controls |
RS, PR, SC, Brazil |
Meyer et al. (2011)5959 Meyer A, Alexandre PCB, Chrisman JR, et al. Esophageal cancer among Brazilian agricultural workers: Case-control study based on death certificates. Int. j. hyg. environ. health. 2011; 214(2):151-155.
|
Glioma |
Case-control |
798 cases + 1,175 controls |
IA, MI, MN, and WI, USA |
Ruder et al. (2009)6767 Ruder AM, Carreón T, Butler MA, et al. Exposure to farm crops, livestock, and farm tasks and risk of glioma. Am. j. epidemiol. 2009; 169(12):1479-1491.
|
Glioma
|
Case-control |
798 cases + 1,175 controls |
IA, MI, MN, and WI, USA |
Yiin et al. (2012)6868 Yiin JH, Ruder AM, Stewart PA, et al. The upper midwest health study: a case-control study of pesticide applicators and risk of glioma. Environ Heal. 2012; 11(39):1-13.
|
HCC
|
Case-control |
3,034 cases + 14,991 controls |
CA, USA |
Vopham et al. (2015)6161 VoPham T, Brooks MM, Yuan JM, et al. Pesticide exposure and hepatocellular carcinoma risk: A case-control study using a geographic information system (GIS) to link SEER-Medicare and California pesticide data. Environ. res. 2015; 143:68-82.
|
Head and neck |
Case-control |
7 cases + 5 controls |
Oklahoma, USA |
Govett et al. (2011)8181 Govett G, Genuis SJ, Govett HE, et al. Chlorinated pesticides and cancer of the head and neck. Eur. j. cancer prev. 2011; 20(4):320-325.
|
HL
|
Case-control |
316 cases + 1,506 controls |
6 provinces, Canada |
Pahwa et al. (2009)3333 Pahwa P, Karunanayake CP, Spinelli JJ, et al. Ethnicity and incidence of Hodgkin lymphoma in Canadian population. BMC cancer. 2009; 9(141):1-9.
|
HL
|
Case-control |
316 cases + 1,506 controls |
6 provinces, Canada |
Karunanayake et al. (2012)3232 Karunanayake CP, Spinelli JJ, McLaughlin JR, et al. Hodgkin Lymphoma and Pesticides Exposure in Men: A Canadian Case-Control Study. J Agromedicine. 2012; 17(1):30-39.
|
Leukemia |
Case-control |
252 cases + 423 controls |
13 states, Brazil |
Ferreira et al. (2013)2626 Ferreira JD, Couto AC, Pombo-de-Oliveira MS, et al. In utero pesticide exposure and leukemia in Brazilian children <2 years of age. Environ. health perspect. 2013; 121(2):269-275.
|
Leukemia |
Cohort |
6,479,406 |
South Korea |
Cha et al. (2014)3030 Cha ES, Hwang S, Lee WJ. Childhood leukemia mortality and farming exposure in South Korea: A national population-based birth cohort study. Cancer epidemiol. 2014; 38(4):401-407.
|
Leukemia |
Case-control |
132 cases + 132 controls |
Rohtak, India |
Kumar et al. (2014)2727 Kumar A, Vashist M, Rathee R. Maternal factors and risk of childhood leukemia. Asian pac. j. cancer prev. 2014; 15(2):781-784.
|
Leukemia |
Ecologic |
Not applicable |
6 states, USA |
Booth et al. (2015)2828 Booth BJ, Ward MH, Turyk ME, et al. Agricultural crop density and risk of childhood cancer in the midwestern United States: an ecologic study. Environ Heal. 2015; 14(82):1-11.
|
Leukemia
|
Case-control |
111 casos + 444 controls |
2 provinces, Italy |
Malagoli et al. (2016)2929 Malagoli C, Costanzini S, Heck JE, et al. Passive exposure to agricultural pesticides and risk of childhood leukemia in an Italian community. Int. j. hyg. environ. health. 2016; 219(8):742-748.
|
Leukemia (ALL) |
Case-control |
213 cases + 268 controls |
CA, USA |
Rull et al. (2009)2525 Rull RP, Gunier R, Von Behren J, et al. Residential proximity to agricultural pesticide applications and childhood acute lymphoblastic leukemia. Environ Res. 2009; 109(7):891-899.
|
Leukemia (AML) |
Case-control |
722 cases + 1,444 controls |
Shanghai, China |
Wong et al. (2009)3131 Wong O, Harris F, Yiying W, et al. A hospital-based case-control study of acute myeloid leukemia in Shanghai: Analysis of personal characteristics, lifestyle and environmental risk factors by subtypes of the WHO classification. Regul. Toxiol. pharmacol. 2009; 55(3):340-352.
|
Liver |
Case-control |
281 cases + 20 controls |
Tanta, Egypt |
Azm et al. (2014)6060 Azm ARAE, Yousef M, Mansour N, et al. New insights on non-B non-C hepatocellular carcinoma in mid Delta Region, Egypt. J gastrointest cancer. 2014; 45(3):276-283.
|
Liver and follicular cell lymphoma |
Cohort |
49,616 |
IA and NC, USA |
Silver et al. (2015)6262 Silver SR, Bertke SJ, Hines CJ, et al. Cancer incidence and metolachlor use in the Agricultural Health Study: An update. Int. j. cancer. 2015; 137(11):2630-2643.
|
Lung |
Cohort |
22,830 |
IA and NC, USA |
Jones et al. (2015)2121 Jones RR, DellaValle CT, Flory AR, et al. Accuracy of residential geocoding in the Agricultural Health Study. Int. j. health geogr. 2014; 13(37):1-9.
|
Lung |
Case-control |
546 cases + 49,266 controls |
IA and NC, USA |
Bonner et al. (2017)7676 Bonner MR, Freeman LEB, Hoppin JA, et al. Occupational Exposure to Pesticides and the Incidence of Lung Cancer in the Agricultural Health Study. Environ. health perspect. 2017; 125(4):544-551.
|
LHC
|
Cohort |
23,072 |
IA and NC, USA |
Delancey et al. (2009)2222 Delancey JOL, Alavanja MCR, Coble J, et al. Occupational Exposure to Metribuzin and the Incidence of Cancer in the Agricultural Health Study. Ann. epidemiol. 2009; 19(6):388-395.
|
LHC
|
Case-control |
354 cases + 455 controls |
Tessalia, Greece |
Kokouva et al. (2011)2323 Kokouva M, Bitsolas N, Hadjigeorgiou GM, et al. Pesticide exposure and lymphohaematopoietic cancers: a case-control study in an agricultural region (Larissa, Thessaly, Greece). BMC public health. 2011; 11(1):1-5.
|
LHC
|
Cohort |
37,099 |
IA, USA |
Jones et al. (2014)2121 Jones RR, DellaValle CT, Flory AR, et al. Accuracy of residential geocoding in the Agricultural Health Study. Int. j. health geogr. 2014; 13(37):1-9.
|
LHC
|
Cohort |
76,493 |
USA |
Schinasi et al. (2015)2424 Schinasi LH, De Roos AJ, Ray RM, et al. Insecticide exposure and farm history in relation to risk of lymphomas and leukemias in the Women's Health Initiative observational study cohort. Ann. epidemiol. 2015; 25(11):803-810.
|
Melanoma |
Cohort |
21,416 |
IA and NC, USA |
Mahajan et al. (2007)7878 Mahajan R, Blair A, Coble J, et al. Carbaryl exposure and incident cancer in the Agricultural Health Study. Int j. cancer. 2007; 121(8):1799-1805.
|
MDS
|
Case-control |
126 cases + 102 controls |
Greece |
Avgerinou et al. (2017)8383 Avgerinou C, Giannezi I, Theodoropoulou S, et al. Occupational, dietary, and other risk factors for myelodysplastic syndromes in Western Greece. Hematology. 2017; 22(7):419-429.
|
MM
|
Cohort |
2,992,166 |
Sweden |
Lope et al. (2008)4747 Lope V, Pérez-Gómez B, Aragonés N, et al. Occupation, exposure to chemicals, sensitizing agents, and risk of multiple myeloma in Sweden. Cancer epidemiol. biomark. prev. 2008; 17(11):3123-3127.
|
MM
|
Cohort |
49,093 |
IA and NC, USA |
Rusiecki et al. (2009)4646 Rusiecki JA, Patel R, Koutros S, et al. Cancer incidence among pesticide applicators exposed to permethrin in the Agricultural Health Study. Environ. health perspect. 2009; 117(4):581-586.
|
MM
|
Case-control |
342 cases + 1,506 controls |
6 provinces, Canada |
Pahwa et al. (2012)4444 Pahwa P, Karunanayake CP, Dosman JA, et al. Multiple Myeloma and Exposure to Pesticides: A Canadian Case-Control Study. J Agromedicine. 2012; 17(1):40-50.
|
MM
|
Case-control |
342 cases + 1,357 controls |
6 provinces, Canada |
Kachuri et al. (2013)4343 Kachuri L, Demers PA, Blair A, et al. Multiple pesticide exposures and the risk of multiple myeloma in Canadian men. Int. j. cancer. 2013; 133(8):1846-1858.
|
MM
|
Case-control |
547 cases + 2,700 controls |
USA, Canada |
Presutti et al. (2016)4545 Presutti R, Harris SA, Kachuri L, et al. Pesticide exposures and the risk of multiple myeloma in men: an analysis of the North American Pooled Project (NAPP). Int. j. cancer. 2016; 139(8):1703-1714.
|
NHL
|
Case-control |
858 cases + 1,821 controls |
Germany |
Richardson et al. (2008)3535 Richardson DB, Terschüren C, Hoffmann W. Occupational Risk Factors for Non-Hodgkin's Lymphoma?: A Population-Based Case - Control Study in Northern Germany. Am J Ind Med. 2008; 51:258-268.
|
NHL
|
Cohort |
56,222 |
IA and NC, USA |
Park et al. (2009)4242 Park SK, Kang D, Beane-freeman L, et al. Cancer incidence among paraquat-exposed pesticide applicators in the Agricultural Health Study. Int J Occup Env Heal. 2009; 15(3):274-281.
|
NHL
|
Case-control |
649 cases + 1,298 controls |
Shanghai, China |
Wong et al. (2010)3131 Wong O, Harris F, Yiying W, et al. A hospital-based case-control study of acute myeloid leukemia in Shanghai: Analysis of personal characteristics, lifestyle and environmental risk factors by subtypes of the WHO classification. Regul. Toxiol. pharmacol. 2009; 55(3):340-352.
|
NHL
|
Case-control |
513 cases + 1,506 controls |
6 provinces, Canada |
Hohenadel et al. (2011)4040 Hohenadel K, Harris SA, McLaughlin JR, et al. Exposure to multiple pesticides and risk of non-Hodgkin lymphoma in men from six Canadian provinces. Int. j. environ. res. public health. 2011; 8(6):2320-2330.
|
NHL
|
Case-control |
75 cases + 321 controls |
Saskatchewan, Canada |
Karunanayake et al. (2013)3939 Karunanayake CP, Dosman JA, Pahwa P. Non-hodgkin's lymphoma and work in agriculture: Results of a two case-control studies in Saskatchewan, Canada. Indian j. occup. environ. med. 2013; 17(3):114-121.
|
NHL
|
Cohort |
54,306 |
IA and NC, USA |
Alavanja et al. (2014)4141 Alavanja MCR, Hofmann JN, Lynch CF, et al. Non-Hodgkin lymphoma risk and insecticide, fungicide and fumigant use in the agricultural health study. PLoS One. 2014; 9(10):1-17.
|
NHL
|
Case-control |
1,317 cases + 2,634 controls |
Brazil |
Boccolini et al. (2016)3636 Boccolini PMM, Boccolini CS, Chrisman JR, et al. Non-Hodgkin lymphoma among Brazilian agricultural workers: A death certificate case-control study. Environ Occup Heal. 2016; 72(3):139-144.
|
Pancreatic |
Case-control |
93 cases + 82,503 controls |
IA and NC, USA |
Andreotti et al. (2009)5454 Andreotti G, Freeman LEB, Hou L, et al. Agricultural Pesticide Use and Pancreatic Cancer Risk in the Agricultural Health Study Cohort Gabriella. Int. j. cancer. 2009; 124(10):2495-2500.
|
Prostate |
Cohort |
47,822 |
IA and NC, USA |
Christensen et al. (2010)5252 Christensen CH, Platz EA, Andreotti G, et al. Coumaphos exposure and incident cancer among male participants in the Agricultural Health Study (AHS). Environ. health perspect. 2010; 118(1):92-96.
|
Prostate |
Case-control |
1,153 cases + 3,999 controls |
Canada |
Band et al. (2011)5050 Band PR, Abanto Z, Bert J, et al. Prostate cancer risk and exposure to pesticides in British Columbia Farmers. Prostate. 2011; 71(2):168-183.
|
Prostate |
Case-control |
173 cases + 162 controls |
CA, USA |
Cockburn et al. (2011)4949 Cockburn M, Mills P, Zhang X, et al. Prostate cancer and ambient pesticide exposure in agriculturally intensive areas in California. Am j. epidemiol. 2011; 173(11):1280-1288.
|
Prostate |
Cross-sectional |
2,938 |
Saskatchewan, Canada |
Sharma et al. (2016)5151 Sharma M, Lawson JA, Kanthan R, et al. Factors Associated With the Prevalence of Prostate Cancer in Rural Saskatchewan: The Saskatchewan Rural Health Study. J Rural Heal. 2016; 32(2):125-135.
|
Several types
|
Cohort |
19,717 |
IA and NC, USA |
Bonner et al. (2007)1414 Bonner MR, Coble J, Blair A, et al. Malathion exposure and the incidence of cancer in the agricultural health study. Am J Epidemiol. 2007; 166(9):1023-1034.
|
Several types |
Ecologic |
25,110,289 |
USA |
Carozza et al. (2008)1717 Carozza SE, Li B, Elgethun K, et al. Risk of childhood cancers associated with residence in agriculturally intense areas in the United States. Environ Health Perspect. 2008; 116(4):559-565.
|
Several types
|
Cohort |
49,762 |
IA and NC, USA |
Koutros et al. (2008)1515 Koutros S, Mahajan R, Zheng T, et al. Dichlorvos Exposure and Human Cancer Risk: Results from the Agricultural Health Study. Cancer Causes Control. 2008; 19(1):59-65.
|
Several types
|
Cohort |
47,625 |
IA and NC, USA |
Mozzachio et al. (2008)1212 Mozzachio AM, Rusiecki JA, Hoppin JA, et al. Chlorothalonil exposure and cancer incidence among pesticide applicator participants in the agricultural health study. Environ Res. 2008; 108(3):400-403.
|
Several types
|
Cohort |
48,986 |
IA and NC, USA |
Greenburg et al. (2008)1313 Greenburg DL, Rusiecki J, Koutros S, et al. Cancer incidence among pesticide applicators exposed to captan in the Agricultural Health Study. Cancer Causes Control. 2008; 19(10):1401-1407.
|
Several types |
Cohort |
48,378 |
IA and NC, USA |
Van Bemmel et al. (2008)99 Van Bemmel DM, Visvanathan K, Beane Freeman LE, et al. S-ethyl-N,N-dipropylthiocarbamate exposure and cancer incidence among male pesticide applicators in the agricultural health study: A prospective cohort. Environ Health Perspect. 2008; 116(11):1541-1546.
|
Several types |
Case-control |
1,778 cases + 1,802 controls |
TX, USA |
Carozza et al. (2009)1818 Carozza SE, Li B, Wang Q, et al. Agricultural pesticides and risk of childhood cancers. Int J Hyg Environ Health. 2009; 212(2):186-195.
|
Several types |
Cohort |
19,655 |
IA and NC, USA |
Lynch et al. (2009)1010 Lynch SM, Mahajan R, Beane Freeman LE, et al. Cancer incidence among pesticide applicators exposed to butylate in the Agricultural Health Study (AHS). Environ Res. 2009; 109(7):860-868.
|
Several types |
Cohort |
44,624 |
IA and NC, USA |
Bonner et al. (2010)1111 Bonner MR, Williams BA, Rusiecki JA, et al. Occupational Exposure to Terbufos and the Incidence of Cancer in the Agricultural Health Study. Cancer Causes Control. 2010; 21(6):871-877.
|
Several types |
Cohort |
62,960 |
Great Britain |
Frost el al. (2011)4848 Frost G, Brown T, Harding AH. Mortality and cancer incidence among British agricultural pesticide users. Occup Med (Lond). 2011; 61(5):303-310.
|
Several types |
Case-control |
34,205 cases + 1,832,969 controls |
Andalusia, Spain |
Parrón et al. (2014)3434 Parrón T, Requena M, Hernández AF, et al. Environmental exposure to pesticides and cancer risk in multiple human organ systems. Toxicol. lett. 2014; 230(2):157-165.
|
Several types |
Cohort |
30,003 |
IA and NC, USA |
Lerro et al. (2015)7171 Lerro CC, Koutros S, Andreotti G, et al. Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study. Occup Environ Med. 2015; 72(10):736-744.
|
Several types |
Case-control |
887 cases + 11,491 controls |
Italy |
Salerno et al. (2016)1919 Salerno C, Carcagnì A, Sacco S, et al. An Italian population-based case-control study on the association between farming and cancer: are pesticides a plausible risk factor? Arch Environ Occup Heal. 2016; 71(3):147-156.
|
Several types |
Case-control |
3,350 cases + 20,365 controls |
Spain |
Gómez-Barroso et al. (2016)1616 Gómez-Barroso D, García-Pérez J, López-Abente G, et al. Agricultural crop exposure and risk of childhood cancer: new findings from a case-control study in Spain. Int J Health Geogr. 2016; 15(1):18.
|
Several types |
Cohort |
70,570 |
Canada |
Kachuri et al. (2017)3737 Kachuri L, Harris MA, MacLeod JS, et al. Cancer risks in a population-based study of 70,570 agricultural workers: results from the Canadian census health and Environment cohort (CanCHEC). BMC cancer. 2017; 17(343):1-15.
|
Several types |
Cohort |
181,842 |
France |
Lemarchand et al. (2017)2020 Lemarchand C, Tual S, Levêque-Morlais N, et al. Cancer incidence in the AGRICAN cohort study (2005-2011). Cancer Epidemiol. 2017; 49:175-185.
|
Stomach |
Cohort |
53,588 |
IA and NC, USA |
Barry et al. (2012)5555 Barry KH, Koutros S, Lubin JH, et al. Methyl bromide exposure and cancer risk in the Agricultural Health Study. Cancer causes control. 2012; 23(6):807-818.
|
STSk |
Case-control |
357 cases + 1,506 controls |
6 provinces, Canada |
Pahwa et al. (2011)8080 Pahwa P, Karunanayake CP, Dosman JA, et al. Soft-Tissue Sarcoma and Pesticides Exposure in Men. J. occup environ. med. 2011; 53(11):1279-1286.
|
Thyroid |
Cohort |
36,357 |
IA and NC, USA |
Freeman et al., (2011)8282 Freeman LEB, Rusiecki JA, Hoppin JA, et al. Atrazine and cancer incidence among pesticide applicators in the Agricultural Health Study (1994-2007). Environ health perspect. 2011; 119(9):1253-1259.
|
Uveal melanoma
|
Case-control |
293 cases + 3,198 controls |
9 European countries1
|
Behrens et al. (2012)7979 Behrens T, Lynge E, Cree I, et al. Pesticide exposure in farming and forestry and the risk of uveal melanoma. Cancer causes control. 2012; 23(1):141-151.
|