Response to letter to the editor

LETTER TO THE EDITOR

Response to letter to the editor

Abrahão Elias Hallack NetoI; Sheila Aparecida Coelho SiqueiraII; Frederico Luiz DulleyIII; Alfredo ChauobahIV; Marcelo BelessoV; Rosaura SaboiaV; Milton Artur RuizV; Dalton Alencar Fischer ChamoneVI; Juliana PereiraV

IMD, PhD. Adjunct professor, Department of Internal Medicine, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil

IIMD, PhD. Attending physician, Department of Pathological Anatomy, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

IIIMD, PhD. Associate professor, Department of Hematology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

IVMD, PhD. Associate professor, Department of Statistics, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil

VMD. Attending physician, Department of Hematology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

VIMD, PhD. Titular professor, Department of Hematology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

Address for correspondence

To the Editor

We would like to thank you very much for your attention to and comments on our trial published in issue 128(1) of this journal. As we ourselves acknowledged in the last paragraph of the discussion, the retrospective design of this trial and the small number of patients should be seen as questionable features and, therefore, our results need to be confirmed in a prospective study with more patients. However, despite the low statistical power of retrospective studies, the most important point is that such studies should be performed in order to raise questions and hypotheses for which proof may subsequently be obtained in trials with greater statistical power, in the way provided by prospective controlled trials.

Concerning the observation about the absence of risk classification from the analysis, we would like to clarify that, as described in the Methods section, all the patients enrolled in our trial were classified as intermediate-high and high risk according to the International Prognostic Index (IPI).

Date of first submission: June 30, 2010

Last received: June 30, 2010

Accepted: November 3, 2010

Sources of funding: None

Conflict of interest: None

Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, Brazil

  • Address for correspondence:
    Abrahão Elias Hallack Neto
    Av. Dr. Enéas de Carvalho Aguiar, 155 - 1º andar - sala 61 Cerqueira César
    São Paulo (SP) - Brasil CEP 05403-000
    Tel. (+55 11) 3061-5544 Fax. (+55 32) 3215-1523 Cel. (+55 32) 9112-6692
    E-mail:

Publication Dates

  • Publication in this collection
    10 Mar 2011
  • Date of issue
    Jan 2011
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