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Case Report • Sao Paulo Med. J. 127 (5) • Sept 2009 • https://doi.org/10.1590/S1516-31802009000500011 linkcopy

Open-access Primary malignancy in giant cell tumor: a case report

Malignização primária no tumor de células gigantes: um estudo de caso

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    Abstracts

    CONTEXT: Primary malignancy in giant cell tumor (PMGCT) is rare. It is defined as a high-grade sarcoma originating in a giant cell tumor (GCT) and seems to behave less aggressively than its secondary counterpart does. CASE REPORT: This report presents the case of a 39-year-old female with pain in her left shoulder for one month. Radiography showed a pathological fracture of the proximal humerus associated with an osteolytic lesion. Histopathological analysis showed typical areas of GCT juxtaposed with a sarcomatous component. CONCLUSIONS: PMGCT seems to behave less aggressively than secondary malignancy in GCT, and it may simulate its more common benign counterpart clinically and radiographically. However, it requires a more aggressive type of treatment.

    Bone neoplasms; Bone tissue; Giant cell tumor of bone; Osteosarcoma; Histiocytoma, malignant fibrous

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