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Sao Paulo Medical Journal, Volume: 136, Número: 3, Publicado: 2018
  • Launching the Latin American Epidemiological Cooperation relating to Noncommunicable Diseases Editorial

    Lotufo, Paulo Andrade
  • Translation and validation of Warmometer, a tool for assessing warmth in patient-provider relationships, for use in Brazilian Portuguese Original Article

    Brooke, Marieta Sodré; Nakamura, Mary Uchiyama; Hosomi, Jorge Kioshi; Ribeiro, Meireluci Costa; Sass, Nelson

    Resumo em Inglês:

    ABSTRACT BACKGROUND: Empathy in the patient-provider relationship is associated with important outcomes in healthcare practice. Our aim was to translate and validate Warmometer, a visual tool for assessing warmth in patient-provider relationships, for use in Brazilian Portuguese. DESIGN AND SETTING: Cross-sectional study conducted at an antenatal clinic of a public university hospital in São Paulo, Brazil. METHODS: The instrument was translated into Brazilian Portuguese and culturally adapted. It was tested for reliability and validity among 32 pregnant women, between June 2015 and January 2016. To assess construct validity, it was correlated with the Consultation and Relational Empathy (CARE) scale (gold standard for patient-provider relationships) and the Interpersonal Reactivity Index (IRI). RESULTS: The translated version of Warmometer had good face and content validity, low intra-observer reproducibility (intraclass correlation coefficient, ICC: 0.224; 95% confidence interval, CI -0.589 to 0.621;P = 0.242) and high inter-observer reproducibility (ICC: 0.952; 95% CI 0.902 to 0.977; P < 0.001). There was a strong correlation between Warmometer and CARE (r = 0.632) and a weak correlation between Warmometer and IRI (r = 0.105). CONCLUSIONS: Warmometer was translated, culturally adapted and validated for use in Brazilian Portuguese. The translated version is a reliable tool for assessing the degree of empathy perceived by the patient in a patient-provider relationship.
  • Utilization of food outlets and intake of minimally processed and ultra-processed foods among 7 to 14-year-old schoolchildren. A cross-sectional study Original Article

    Corrêa, Elizabeth Nappi; Retondario, Anabelle; Alves, Mariane de Almeida; Bricarello, Liliana Paula; Rockenbach, Gabriele; Hinnig, Patrícia de Fragas; Neves, Janaina das; Vasconcelos, Francisco de Assis Guedes de

    Resumo em Inglês:

    ABSTRACT BACKGROUND: Access to food retailers is an environmental determinant that influences what people consume. This study aimed to test the association between the use of food outlets and schoolchildren’s intake of minimally processed and ultra-processed foods. DESIGN AND SETTING: This was a cross-sectional study conducted in public and private schools in Florianópolis, state of Santa Catarina, southern Brazil, from September 2012 to June 2013. METHODS: The sample consisted of randomly selected clusters of schoolchildren aged 7 to 14 years, who were attending 30 schools. Parents or guardians provided socioeconomic and demographic data and answered questions about use of food outlets. Dietary intake was surveyed using a dietary recall questionnaire based on the previous day’s intake. The foods or food groups were classified according to the level of processing. Negative binomial regression was used for data analysis. RESULTS: We included 2,195 schoolchildren in the study. We found that buying foods from snack bars or fast-food outlets was associated with the intake frequency of ultra-processed foods among 11-14 years old in an adjusted model (incidence rate ratio, IRR: 1.11; 95% confidence interval, CI: 1.01;1.23). Use of butchers was associated with the intake frequency of unprocessed/minimally processed foods among children 11-14 years old in the crude model (IRR: 1.11; 95% CI: 1.01;1.22) and in the adjusted model (IRR: 1.11; 95% CI: 1.06;1.17). CONCLUSIONS: Use of butchers was associated with higher intake of unprocessed/minimally processed foods while use of snack bars or fast-food outlets may have a negative impact on schoolchildren’s dietary habits.
  • Dietary intake of non-dialysis chronic kidney disease patients: the PROGREDIR study. A cross-sectional study Original Article

    Machado, Alisson Diego; Anjos, Fernanda Silva Nogueira dos; Domingos, Maria Alice Muniz; Molina, Maria del Carmen Bisi; Marchioni, Dirce Maria Lobo; Benseñor, Isabela Judith Martins; Titan, Silvia Maria de Oliveira

    Resumo em Inglês:

    ABSTRACT BACKGROUND: Despite evidence that diet is very important in relation to chronic kidney disease (CKD) progression, studies in this field are scarce and have focused only on some specific nutrients. We evaluated the energy, macronutrient and micronutrient intakes and dietary patterns of non-dialysis CKD participants in the PROGREDIR study. DESIGN AND SETTING: Cross-sectional study; CKD cohort, São Paulo, Brazil. METHODS: Baseline data on 454 participants in the PROGREDIR study were analyzed. Dietary intake was evaluated through a food frequency questionnaire. Dietary patterns were derived through principal component analysis. Energy and protein intakes were compared with National Kidney Foundation recommendations. Linear regression analysis was performed between energy and nutrient intakes and estimated glomerular filtration rate (eGFR), and between sociodemographic and clinical variables and dietary patterns. RESULTS: Median energy and protein intakes were 25.0 kcal/kg and 1.1 g/kg, respectively. In linear regression, protein intake (β = -3.67; P = 0.07) was related to eGFR. Three dietary patterns (snack, mixed and traditional) were retained. The snack pattern was directly associated with male gender (β = 0.27; P = 0.006) and inversely with diabetes (β = -0.23; P = 0.02). The traditional pattern was directly associated with male gender (β = 0.27; P = 0.007) and schooling (β = 0.40; P < 0.001) and inversely with age (β = -0.01; P = 0.001) and hypertension (β = -0.34; P = 0.05). CONCLUSIONS: We identified low energy and high protein intake in this population. Protein intake was inversely related to eGFR. Dietary patterns were associated with age, gender, schooling level, hypertension and diabetes.
  • Pneumo-phono-articulatory coordination assessment in dysarthria cases: a cross-sectional study Original Article

    Chappaz, Rebeca de Oliveira; Barreto, Simone dos Santos; Ortiz, Karin Zazo

    Resumo em Inglês:

    ABSTRACT BACKGROUND: Pneumo-phono-articulatory coordination is often impaired in dysarthric patients. Because all speech is produced upon exhalation, adequate respiratory support and coordination are essential for communication. Nevertheless, studies investigating respiratory parameters for speech are scarce. The objectives of the present study were to analyze and compare the numbers of words and syllables (universal measurement) per exhalation among healthy and dysarthric speakers, in different speech tasks. DESIGN AND SETTING: A cross-sectional analytical study with a control group was conducted at the Department of Speech, Language and Hearing Sciences at UNIFESP. METHODS: The study sample consisted of 62 individuals: 31 dysarthric patients and 31 healthy individuals matched for sex, age and education level. All participants performed number counting and text reading tests in which the numbers of words and syllables per exhalation were recorded. All measurements obtained from the two groups were compared. RESULTS: Statistically significant differences between the dysarthric and healthy groups were found in the two tasks (counting of syllables and words per exhalation) (P < 0.001). In contrast, the performance of the dysarthric patients did not vary according to the task: reading and number counting in syllables/exhalation (P = 0.821) or words/exhalation (P = 0.785). CONCLUSIONS: The mean numbers of words and syllables per exhalation among dysarthric subjects did not vary according to the speech task used but they clearly showed differences between dysarthric patients and normal healthy subjects. The study also made it possible to obtain preliminary data on the average numbers of words and syllables per expiration produced by healthy individuals during their speech production.
  • Helicobacter pylori infection in family members of patients with gastroduodenal symptoms. A cross-sectional analytical study Original Article

    Palanduz, Ayse; Erdem, Levent; Cetin, Birsen Durmaz; Ozcan, Nuran Gülgün

    Resumo em Inglês:

    ABSTRACT BACKGROUND: Primary Helicobacter pylori (H. pylori) infection is acquired predominantly in childhood in the family setting. We aimed to investigate the presence of intrafamilial concurrent H. pylori infection. DESIGN AND SETTING: Cross-sectional analytical study with a control group, conducted in a tertiary care hospital. METHODS: Fifty adult patients with gastroduodenal symptoms who underwent gastroscopy (index parents), their spouses and their children were enrolled in the study. Blood samples were collected from all of the study subjects to test for immunoglobulin G (IgG) antibody response. H. pylori antigen was investigated in the stool specimens of children only. RESULTS: The participants were divided into two groups: Group 1 consisted of the 40 patients in whom H. pylori infection was demonstrated via endoscopy, their spouses and their children. Group 2 included the remaining 10 patients who underwent endoscopy revealing negative results for H. pylori, their spouses and their children. IgG antibodies were present in all of the index parents, 95% of their spouses and 93% of their children in group 1; 13 of the children (9%) were also positive for H. pylori stool antigen (HpSA). However, IgG antibodies were present in only 2 of the 10 index parents in group 2. One of their spouses and one of their children had a positive antibody response. All of their children had negative stool antigen test results. CONCLUSION: H. pylori infections exhibit intrafamilial clustering. Parental infection, age ≥ years and having three or more siblings are the major risk factors for H. pylori infection in children.
  • Body mass index and association with use of and distance from places for physical activity and active leisure among schoolchildren in Brazil. Cross-sectional study Original Article

    Rossi, Camila Elizandra; Correa, Elizabeth Nappi; Neves, Janaina das; Gabriel, Cristine Garcia; Benedet, Jucemar; Rech, Cassiano Ricardo; Vasconcelos, Francisco de Assis Guedes de

    Resumo em Inglês:

    ABSTRACT BACKGROUND: We evaluated associations between use of public places for physical activity and active leisure (PAAL) and their distances from subjects’ homes and indicators of overweight and obesity, among schoolchildren from different socioeconomic levels, in the city of Florianópolis, Brazil. DESIGN AND SETTING: Cross-sectional study conducted on a sample of 2,152 schoolchildren aged 7 to 14 years, enrolled at 30 public and private schools. METHODS: The exposure variables were the use of public places for PAAL in the neighborhood and their distance from schoolchildren’s homes. The outcomes were body mass index (BMI) and waist circumference (WC). Univariate and multivariate linear regression analyses were conducted according to income strata. RESULTS: Among the schoolchildren from low-income families, living closer to parks/playgrounds was associated with lower BMI (β = -2.15; 95% confidence interval, CI = -2.53; -1.77) and lower WC (β = -0.11 95% CI = -0.17; -0.05), while living at these distances from football pitches was associated with higher BMI (β = 1.73; 95% CI = 0.31; 3.15) and larger WC measurements (β = 0.03; 95% CI = 0.005; 0.14). Among the schoolchildren in low-income groups, living at an intermediate distance from beaches was associated with lower BMI (β = -1.10; 95% CI = -1.61; -0.59). CONCLUSION: Living closer to parks/playgrounds was associated with lower BMI and WC among schoolchildren from low-income families. Living closer to football pitches was associated with higher BMI and WC among these schoolchildren. Living at intermediate distances from beaches was associated with lower BMI among these schoolchildren.
  • Social, behavioral and biological correlates of cardiorespiratory fitness according to sex, nutritional status and maturity status among adolescents. A cross-sectional study Original Article

    Werneck, André Oliveira; Silva, Danilo Rodrigues; Agostinete, Ricardo Ribeiro; Fernandes, Rômulo Araújo; Ronque, Enio Ricardo Vaz; Cyrino, Edilson Serpeloni

    Resumo em Inglês:

    ABSTRACT BACKGROUND: Our aim was to analyze multilevel correlates of cardiorespiratory fitness (CRF) according to sex, nutritional status and maturity status among adolescents. DESIGN AND SETTING: Cross-sectional study conducted in public schools. METHODS: This was a cross-sectional study on 1,209 adolescents aged between 10 and 17 years. CRF was estimated from the 20-meter shuttle run test. Anthropometric data on body mass index and waist circumference were obtained. Somatic maturation was assessed from the peak height velocity. Questionnaires were used to evaluate socioeconomic variables (family income, parents’ education level and number of siblings) and behavioral variables (physical activity, screen time and alcohol and tobacco consumption) among the parents and adolescents. RESULTS: Boys, adolescents with normal weight and on-time maturers presented greater CRF (P < 0.05). Concerning socioeconomic correlates, girls (tobacco smoking, alcohol consumption, physical activity and screen time), adolescents with normal weight (alcohol consumption, physical activity and screen time), and on-time maturers (alcohol consumption, physical activity during childhood and habitual physical activity) demonstrated higher numbers of behavioral correlates with CRF. Normal-weight adolescents presented a higher number of biological correlates (chronological age, age at peak height velocity and waist circumference). CONCLUSIONS: Different correlates were observed according to sex, nutritional status and somatic maturation status. However, habitual physical activity, waist circumference and chronological age seemed to be the strongest factors associated with cardiorespiratory fitness among adolescents.
  • Coarse particles and hospital admissions due to respiratory diseases in children. An ecological time series study Original Article

    César, Ana Cristina Gobbo; Nascimento, Luiz Fernando

    Resumo em Inglês:

    ABSTRACT BACKGROUND: Exposure to particulate matter (PM) is associated with hospitalizations due to respiratory diseases among children. DESIGN AND SETTING: An ecological time series study was carried out to identify the role of coarse fractions of particulate matter (PM10-2.5) in hospitalizations among children up to 10 years of age, in Piracicaba (SP) in the year 2015. METHODS: A generalized additive model of Poisson regression was used to estimate the risk of hospitalization due to acute laryngitis and tracheitis, pneumonia, bronchitis, bronchiolitis and asthma. Lags of 0 to 7 days were considered, and the model was adjusted for the temperature and relative humidity of the air and controlled for short and long-term exposure. Proportional attributable ratios, population-attributable fractions and hospital costs were calculated with increasing concentrations of these pollutants. RESULTS: 638 hospitalizations were evaluated during this period, with a mean of 1.75 cases per day (standard deviation, SD = 1.86). The daily averages were 22.45 µg/m3 (SD = 13.25) for the coarse fraction (PM10-2.5) and 13.32 µg/m3 (SD = 6.38) for the fine fraction. Significant risks of PM10-2.5 exposure were only observed at lag 0, with relative risk (RR) = 1.012, and at lag 6, with RR = 1.011. An increase of 5 µg/m3 in the coarse fraction concentration implied an increase in the relative risk of hospitalizations of up to 4.8%, with an excess of 72 hospitalizations and excess expenditure of US$ 17,000 per year. CONCLUSIONS: This study showed the impact of coarse-fraction exposure on hospital admissions among children due to respiratory diseases.
  • What do Cochrane systematic reviews say about new practices on integrative medicine? Narrative Review

    Riera, Rachel; Braga, Vinícius Lopes; Rocha, Luana Pompeu dos Santos; Bernardo, Daniel Damasceno; Andrade, Luísa Avelar Fernandes de; Hsu, Jessica Chiu; Silva, Luciana Di Giovanni Marques da; Suetsugu, Rodrigo Cesar de Sá; Dittrich, Nicole Hosni; Lima, Lucas Riguete Pereira de; Silveira, Vicente Penido da; Kruglensky, Barbara Caon; Leonel, Letícia de Freitas; Barros, Edivando de Moura; Costa, Anderson Adriano Leal Freitas da; Quintella, Miguel Lins; Pacheco, Rafael Leite; Cruz, Carolina de Oliveira; Martimbianco, Ana Luiza Cabrera; Pachito, Daniela Vianna; Mozetic, Vania; Teixeira, Tatiana de Bruyn Ferraz; Torloni, Maria Regina; Atallah, Alvaro Nagib

    Resumo em Inglês:

    ABSTRACT BACKGROUND: This study identified and summarized all Cochrane systematic reviews (SRs) on the effects of ten integrative practices that were recently added to the Brazilian public healthcare system (SUS). DESIGN AND SETTING: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp). METHODS: Review of Cochrane SRs on the following interventions were identified, summarized and critically assessed: apitherapy, aromatherapy, bioenergetics, family constellation, flower therapy, chromotherapy, geotherapy, hypnotherapy, hand imposition or ozone therapy. RESULTS: We included a total of 16 SRs: 4 on apitherapy, 4 on aromatherapy, 6 on hypnotherapy and 2 on ozone therapy. No Cochrane SR was found regarding bioenergetics, family constellation, chromotherapy, clay therapy, flower therapy or hand imposition. The only high-quality evidence was in relation to the potential benefit of apitherapy, specifically regarding some benefits from honey dressings for partial healing of burn wounds, for reduction of coughing among children with acute coughs and for preventing allergic reactions to insect stings. CONCLUSION: Except for some specific uses of apitherapy (honey for burn wounds and for acute coughs and bee venom for allergic reactions to insect stings), the use of ten integrative practices that have recently been incorporated into SUS does not seem to be supported by evidence from Cochrane SRs.
  • Adenocarcinoma metastático envolvendo o ventrículo direito e artéria pulmonar levando a insuficiência cardíaca direita: relato de caso Case Report

    Karabag, Turgut; Arslan, Caner; Yakisan, Turab; Vatan, Aziz; Sak, Duygu

    Resumo em Português:

    RESUMO CONTEXTO: A obstrução da via de saída do ventrículo direito devido a doença metastática é rara. O reconhecimento clínico de tumores cardíacos metastáticos é raro e continua a apresentar um desafio diagnóstico e terapêutico. RELATO DO CASO: Apresentamos o caso de um paciente com insuficiência respiratória grave e cujos exames clínicos revelaram massa de tumor gigante, estendendo-se desde o ventrículo direito até a artéria pulmonar. Discutimos as opções diagnósticas e terapêuticas. CONCLUSÃO: Em pacientes com insuficiência cardíaca direita aguda, massas do ventrículo direito devem ser mantidas em mente. Ecocardiografia transtorácica parece ser a técnica mais facilmente disponível, não invasiva, custo-efetiva e útil no diagnóstico diferencial.

    Resumo em Inglês:

    ABSTRACT CONTEXT: Obstruction of the right ventricular outflow tract due to metastatic disease is rare. Clinical recognition of cardiac metastatic tumors is rare and continues to present a diagnostic and therapeutic challenge. CASE REPORT: We present the case of a patient who had severe respiratory insufficiency and whose clinical examinations revealed a giant tumor mass extending from the right ventricle to the pulmonary artery. We discuss the diagnostic and therapeutic options. CONCLUSION: In patients presenting with acute right heart failure, right ventricular masses should be kept in mind. Transthoracic echocardiography appears to be the most easily available, noninvasive, cost-effective and useful technique in making the differential diagnosis.
  • Broncoscopia flexível e ventilação mecânica no tratamento da síndrome de Mounier-Kuhn: relato de caso Case Report

    Kaya, Aslihan Gürün; Çiledağ, Aydin; Atasoy, Çetin; Karnak, Demet

    Resumo em Português:

    RESUMO CONTEXTO: A síndrome de Mounier-Kuhn é uma condição congênita rara com dilatação e diverticulação distintas da parede traqueal. Os sintomas podem ser variáveis ​e o tratamento geralmente é de suporte. RELATO DE CASO: Paciente do sexo masculino, de 60 anos, com internação hospitalar recorrente, foi internado neste caso devido a dispneia, tosse e produção de expectoração. A amostra de sangue arterial revelou acidose respiratória descompensada, com hipoxemia moderada. A tomografia computadorizada de tórax mostrou dilatação da traqueia e brônquios, divertículos traqueais e bronquiectasias. Realizou-se broncoscopia flexível, que revelou aumento das vias aéreas com colapso expiratório. Além disso, também foram detectados orifícios de diverticulose traqueal. Foi adicionada ventilação com pressão positiva não invasiva (NPPV) juntamente com a oxigenoterapia a longo prazo. Foram verificadas melhoras dos resultados clínicos e laboratoriais do doente nas visitas de controle. CONCLUSÃO: A broncoscopia flexível pode ser defendida para estabelecer o diagnóstico, e a ventilação mecânica não invasiva pode ser utilizada com alta taxa de sucesso, para bem-estar clínico, na síndrome de Mounier-Kuhn.

    Resumo em Inglês:

    ABSTRACT CONTEXT: Mounier-Kuhn syndrome is a rare congenital condition with distinct dilatation and diverticulation of the tracheal wall. The symptoms may vary and the treatment usually consists of support. CASE REPORT: The patient was a 60-year-old male with recurrent hospital admission. He was admitted in this case due to dyspnea, cough and sputum production. An arterial blood sample revealed decompensated respiratory acidosis with moderate hypoxemia. A chest computed tomography (CT) scan showed dilatation of the trachea and bronchi, tracheal diverticula and bronchiectasis. Flexible bronchoscopy was performed, which revealed enlarged airways with expiratory collapse. Furthermore, orifices of tracheal diverticulosis were also detected. Non-invasive positive pressure ventilation (NPPV) was added, along with long-term oxygen therapy. At control visits, the patient’s clinical and laboratory findings were found to have improved. CONCLUSION: Flexible bronchoscopy can be advocated for establishing the diagnosis and non-invasive mechanical ventilation can be used with a high success rate, for clinical wellbeing in Mounier-Kuhn syndrome.
  • Myalgia-arthralgia syndrome induced by docetaxel in oncology: the wolf disguised as a sheep Letter To The Editor

    Cidon, Esther Una
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