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Efficacy, patient-doctor relationship, costs and benefits of utilizing telepsychiatry for the management of post-traumatic stress disorder (PTSD): a systematic review

Abstract

Introduction

Post-traumatic stress disorder (PTSD) is one of the most common psychiatric disorders found among victims of disaster, kidnapping, accidents, sexual assaults and war in Indonesia. However, lacking and unequal distribution of psychiatric medical personnel remains a barrier to its management. This review aims to introduce and evaluate the potential contribution of telepsychiatry to the management of PTSD based on published literature.

Methods

Original studies were obtained from PubMed, Science Direct, ProQuest, High Wire, and Elsevier Clinical Key databases.

Results

A total of 125 articles were found, of which 15 articles (12 randomized controlled trials, 2 open trials and 1 pilot study) fulfilled the inclusion criteria. A total of 991 subjects were found with a follow-up period ranging between 5 weeks and 18 months. Telepsychiatry is an innovative use of technology to aid the delivery of PTSD treatments in areas difficult to reach. The quality of care given by telepsychiatry both through video conferencing as well as web- and application-based is comparable to that of face-to-face therapy. Patient satisfaction, quality of doctor-patient relationship also remains high, with lower costs and shorter therapeutic time when compared to face-to-face therapy.

Conclusion

Various studies have shown that telepsychiatry is an effective solution for the management of PTSD. Studies have also reported that the quality of treatment through telepsychiatry is as effective as face-to-face therapy, with greater efficiency. Countries, especially those with a low patient-to-mental health professional ratio, should be encouraged to develop telepsychiatry systems to manage PTSD.

Telepsychiatry; post-traumatic stress disorder; telemedicine

Introduction

Globally, around 61% of males and 50% of females will face at least one traumatic event throughout their life. Traumatic events include war, violence (sexual violence, physical attacks, etc.), kidnappings, torture, terrorism, road accidents and natural disasters. Sexual violence, witnessing a tragic death or horrifying injury during one’s childhood is also one of the main causes of lifelong trauma.11. Javidi H, Yadollahie M. Post-traumatic stress disorder. Int J Occup Environ Med. 2012;3:2-9.

The World Health Organization (WHO) in 2013 reported that an average 3.6% of the world’s population suffers from post-traumatic stress disorder (PTSD), with a distribution of 28.5% in the Western Pacific and 27.4% in Southeast Asia.22. World Health Organization. WHO releases guidance on mental health care after trauma [online]. 2013 [cited 2018 Aug 24]. http://www.who.int/mediacentre/news/releases/2013/trauma_mental_health_20130806/en/
http://www.who.int/mediacentre/news/rele...
In Indonesia, the most recent national health survey conducted by the Ministry of Health in 2018 reported that the prevalence of psychiatric disorders was 9.8%, rising from 6% in 2013, although there were no specific data on the prevalence of PTSD.33. Republic of Indonesia, Ministry of Health. National Basic Health Survey. Jakarta: Ministry of Health; 2018. This may be a result of an increase in the number of sex-related cases,44. Republic of Indonesia, State Intelligence Agency. Waspada terhadap pelecehan seksual pada anak usia dini [online]. 2018 [cited 2018 Sep 10]. http://www.bin.go.id/awas/detil/458/4/20/07/2018/waspada-terhadap-pelecehan-seksual-pada-anak-usia-dini
http://www.bin.go.id/awas/detil/458/4/20...
violent criminal offenses,55. Republic of Indonesia, Indonesian National Police. National Criminal Information Center [online]. 2018 [cited 2018 Sep 10]. https://pusiknas.polri.go.id/kamtibmas.html
https://pusiknas.polri.go.id/kamtibmas.h...
road accidents,66. Republic of Indonesia, Ministry of Transportation. Transportation Statistics Book 1 Year 2017. Jakarta: Ministry of Transportation; 2017. all of which are main triggers of PTSD. Furthermore, terrorism, forced evictions and increasing competition in life have also contributed to the rise in PTSD cases in Indonesia, especially in disaster-prone areas.77. Chandra ZA. Pengaruh dukungan sosial keluarga terhadap kesembuhan penderita post traumatic stress disorder (PTSD) di pusat pelayanan terpadu (ppt) “mawar” rsud dr. fauziah bireuen tahun 2009 [thesis]. Medan: Universitas Sumatera Utara; 2009.

8. Erwina I. The influence of cognitive behavior therapy toward of post traumatic stress disorder on post earthquake population in air tawar barat urban village, north padang, west sumatera [thesis]. Depok: Universitas Indonesia; 2010.
-99. Frankenberg E, Nobles J, Sumantri C. Community destruction and traumatic stress in post-tsunami Indonesia. J Health Soc Behav. 2012;53:498-514.

PTSD is a psychiatric disorder caused by traumatic events or a series of traumatic events involving oneself, others or their loved ones and having resulted in death, serious injuries or both.1010. Sadock B, Sadock V. Kaplan and Sadock’s synopsis of psychiatry. 11th ed. Alphen aan den Rijn: Wolters Kluwer; 2014. Patients with PTSD show signs of anxiousness, fear, repeated flashbacks of the traumatic event, avoidance of objects, locations etc. associated with the event; they withdraw themselves emotionally (emotional numbing) and respond overwhelmingly to similar events.1111. National Institute of Mental Health. National Institute of Mental Health | Post-Traumatic Stress Disorder (PTSD) [online]. [cited 2018 Oct 24]. http://www.nimh.nih.gov/health/topics/post-traumatic-stress-disorder-ptsd/index.shtml
http://www.nimh.nih.gov/health/topics/po...

12. Bomyea J, Lang AJ. Emerging interventions for PTSD: Future directions for clinical care and research. Neuropharmacology. 2012;62:607-16.
-1313. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition. Arlington: American Psychiatric Association; 2013.

PTSD does not always appear immediately after the triggering event, but may appear within weeks or even 30 years after the event has occurred.1010. Sadock B, Sadock V. Kaplan and Sadock’s synopsis of psychiatry. 11th ed. Alphen aan den Rijn: Wolters Kluwer; 2014. Symptoms also fluctuate over time and especially worsen during periods of stress. Without proper management, only 30% of patients recover on their own, 40% will always present minor symptoms and 10% worsen over time. A poorer prognosis is observed among children and the elderly, due to their greater emotional vulnerability and poor coping mechanisms.1010. Sadock B, Sadock V. Kaplan and Sadock’s synopsis of psychiatry. 11th ed. Alphen aan den Rijn: Wolters Kluwer; 2014.

Untreated PTSD has been proven to affect both cognitive and learning function. Patients with PTSD have difficulties in concentration, cognition and emotion management, which can negatively impact their interpersonal relations and impair their decision-making skills in life. PTSD also lowers work and academic achievements. In the end, PTSD can lower one’s quality of life, productivity and inadvertently lead to huge social costs to society.1414. Central Java Provincial Research and Development Department. [Post traumatic stress disorder (post disaster traumatic stress disorder) in Central Java]. Semarang: Central Java Provincial Government; 2008.,1515. Lubis FY, Dalimunthe KL. Impact of disaster event on student’s cognition achievement in SMAN 1 Pangalengan and SMA Aliyah Pangalengan, West Java, Indonesia. GSTF J Law Soc Sci. 2012;1:53-6.

Although PTSD leads to numerous negative consequences, patients with PTSD are often not managed adequately. This is potentially caused by lack of awareness among PTSD sufferers as well as difficulty receiving therapy, due to the scarcity of psychiatric medical resources.1010. Sadock B, Sadock V. Kaplan and Sadock’s synopsis of psychiatry. 11th ed. Alphen aan den Rijn: Wolters Kluwer; 2014.,1212. Bomyea J, Lang AJ. Emerging interventions for PTSD: Future directions for clinical care and research. Neuropharmacology. 2012;62:607-16.,1616. Sebayang SK, Mawarpury M, Rosemary R. Jakarta Post [online]. 2018 [cited 2018 Oct 24]. https://www.thejakartapost.com/academia/2018/11/06/less-than-1000-psychiatrists-for-260-million-indonesians.html
https://www.thejakartapost.com/academia/...

Currently, there are many different types of psychotherapy available for PTSD, such as prolonged exposure, cognitive behavioral therapy (CBT), and eye movement desensitization and reprocessing (EMDR), all of which have been proven effective in managing patients with PTSD.1212. Bomyea J, Lang AJ. Emerging interventions for PTSD: Future directions for clinical care and research. Neuropharmacology. 2012;62:607-16. Psychotherapy does not involve the use of medications, but instead aims to change the way someone feels about the trauma that they have faced.1010. Sadock B, Sadock V. Kaplan and Sadock’s synopsis of psychiatry. 11th ed. Alphen aan den Rijn: Wolters Kluwer; 2014.

The lack of psychiatric health professionals such as psychiatrists, clinical psychologists and psychiatric nurses, as well as limited access to and distribution of these services are among the several barriers in managing PTSD throughout the world, especially in developing countries. In 2018, it was reported that there were only 773 psychiatrists (0.32 per 100,000 population) and 451 clinical psychologists (0.15 per 100.000 population) in Indonesia, severely low numbers compared to the WHO recommendations of 1 psychologist and psychiatrist per 30,000 population or 3.33 per 100,000 population. Distribution of psychiatric care also remains uneven and mostly concentrated in urban areas. These factors have made PTSD treatment become rare and expensive in many developing countries, including Indonesia.1212. Bomyea J, Lang AJ. Emerging interventions for PTSD: Future directions for clinical care and research. Neuropharmacology. 2012;62:607-16.,1616. Sebayang SK, Mawarpury M, Rosemary R. Jakarta Post [online]. 2018 [cited 2018 Oct 24]. https://www.thejakartapost.com/academia/2018/11/06/less-than-1000-psychiatrists-for-260-million-indonesians.html
https://www.thejakartapost.com/academia/...

Telemedicine

Telemedicine refers to the remote provision of medical services, i.e., distant from the medical professional, through the use of information technology to aid in the exchange of health information for the purpose of diagnosis, management and prevention of diseases, research and evaluation, and also to improve the knowledge of health professionals with the sole aim of improving health care for both the community and society.1717. World Health Organization. Telemedicine: Opportunities and developments in member states. Geneva: World Health Organization; 2010. Telemedicine links doctors from a referral center/hospital to health professionals and patients elsewhere, in their homes, community health centers, etc., through the use of various telecommunication media such as satellite and fiber optics.1818. Solar Surya Indonesia. Solar Surya Indonesia [online]. 2013 [cited 2018 Oct 24]. http://solarsuryaindonesia.com/news/mengintip-teknologi-mobil-tanggap-bencana-besutan-kominfo
http://solarsuryaindonesia.com/news/meng...

19. InSight. Scheduled telepsychiatry services [online]. 2014 [cited 2018 October 24]. http://insighttelepsychiatry.com/scheduled-telepsychiatry-services-2/
http://insighttelepsychiatry.com/schedul...
-2020. Vestal C. In rural SC, telepsychiatry cuts wait times for mental health exams from 4 days to 10 hours [online]. Medcity News. 2014 Jun 27 [cited 2018 Oct 24]. http://medcitynews.com/2014/06/telepsychiatry-reduces-wait-times-psyciatric-exams-4-days-10-hours-sc-hospital/
http://medcitynews.com/2014/06/telepsych...

In 2016, the WHO reported that 77% of 125 countries throughout the world had implemented telemedicine. One of the main reasons behind telemedicine use is its ability to provide health care to remote areas, which are difficult to reach by health professionals.2121. World Health Organization. Global diffusion of eHealth: making universal health coverage achievable. Geneva: WHO/Global Observatory for eHealth; 2016. Telemedicine is also able to facilitate training of volunteers as well as health professionals both in remote areas and during natural disasters.1717. World Health Organization. Telemedicine: Opportunities and developments in member states. Geneva: World Health Organization; 2010.,2222. Zafar A. International Telecommunication Union [online]. 2011 [cited 2018 Oct 24]. http://www.itu.int/ITU-D/emergencytelecoms/events/Zimbabwe_2011/Applications%20of%20telemedicine%20in%20Emergencies_Harare_2011_1.pdf
http://www.itu.int/ITU-D/emergencyteleco...
Hence, telemedicine has great potential in bridging the current need for better PTSD management throughout in Indonesia and similar developing countries with a low mental health professional to population ratio. The use of telemedicine for the care of psychiatric patients is referred to as telepsychiatry.22. World Health Organization. WHO releases guidance on mental health care after trauma [online]. 2013 [cited 2018 Aug 24]. http://www.who.int/mediacentre/news/releases/2013/trauma_mental_health_20130806/en/
http://www.who.int/mediacentre/news/rele...
,2323. Germain V, Marchand A, Bouchard S, Drouin MS, Guay S. Effectiveness of cognitive behavioural therapy administered by videoconference for posttraumatic stress disorder. Cogn Behav Ther. 2009;38:42-53.,2424. O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? results from a randomized controlled equivalence trial. Psychiatric Serv. 2007;58:836-43. This review therefore aims to evaluate the potential of telepsychiatry as an alternative solution to overcome the barriers to better PTSD care in Indonesia and other countries.

Materials and methods

Data source

The databases searched to obtain the articles included PubMed, Science Direct, ProQuest, High Wire, and Elsevier Clinical Key. The search strategies used included availability of full text written in English and published from January 2003 to December 2017. The following keywords were used: “post-traumatic stress disorder or delayed stress disorder” and “telepsychiatry or telemedicine or telehealth or e-health or teleconsultation or video conference or telecare AND psychiatry.” When multiple articles deriving from the same study were found, only the most recent publication was included. An approach based on title, abstract, and full text was used to evaluate the relevance of articles.

Study selection

Studies were included if they were original studies and if they had one of the following designs: randomized controlled trial (RCT), case-control study, and cohort study. Ideally, PTSD in the studies should be diagnosed in accordance to the criteria found in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) by the American Psychiatric Association (APA).1313. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition. Arlington: American Psychiatric Association; 2013.

In addition, studies were included if: 1) they included patients with PTSD and management was carried out through telepsychiatry with any method or length of time; 2) parameters related to the control of symptoms, therapeutic alliance, economic effects were reported; 3) studies compared telepsychiatry use vs. routine care; or 4) studies compared patients treated with telepsychiatry vs. another type of management with placebo as control. Studies not meeting these criteria were excluded from this review.

Results and discussion

Our initial search resulted in 125 articles, of which 39 were excluded due to duplicate citations. Fifty-seven were then excluded on the basis of title and abstract. Of the remaining 29 studies, 13 were excluded because they did not meet the inclusion criteria, 2 reported on acute stress disorder and not PTSD, 4 were editorials, 5 studied substance abuse with PTSD rather than PTSD alone, and 2 were duplicate publications of the same study. Finally, 15 articles were found that fulfilled all of our inclusion criteria: 12 RCTs, 2 open trials, and 1 pilot study (Figure 1).

Figure 1
Data selection flow chart

Sample size varied across studies, ranging from 152525. Wagner B, Schulz W, Knaevelsrud C. Efficacy of an Internet-based intervention for posttraumatic stress disorder in Iraq: A pilot study. Psychiatry Res. 2012;195:85-8. to 2412424. O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? results from a randomized controlled equivalence trial. Psychiatric Serv. 2007;58:836-43. patients, with a follow-up duration ranging between 5 weeks2626. Wagner B, Brand J, Schulz W, Knaevelsrud C. Online working alliance predicts treatment outcome for posttraumatic stress symptoms in Arab war-traumatized patients. Depress Anxiety. 2012;29:646-51. and 18 months.2727. Knaevelsrud C, Maercker A. Long-term effects of an internet-based treatment for posttraumatic stress. Cogn Behav Ther. 2010;39:72-7. The total number of subjects considering all studies was 991. The majority of studies were published from 2010 onwards and conducted in developed nations. Five studies were conducted in Germany,2525. Wagner B, Schulz W, Knaevelsrud C. Efficacy of an Internet-based intervention for posttraumatic stress disorder in Iraq: A pilot study. Psychiatry Res. 2012;195:85-8.

26. Wagner B, Brand J, Schulz W, Knaevelsrud C. Online working alliance predicts treatment outcome for posttraumatic stress symptoms in Arab war-traumatized patients. Depress Anxiety. 2012;29:646-51.

27. Knaevelsrud C, Maercker A. Long-term effects of an internet-based treatment for posttraumatic stress. Cogn Behav Ther. 2010;39:72-7.

28. Knaevelsrud C, Maercker A. Internet-based treatment for PTSD reduces distress and facilitates the development of a strong therapeutic alliance: a randomized controlled clinical trial. BMC Psychiatry. 2007;7:13.
-2929. Kersting A, Dolemeyer R, Steinig J, Walter F, Kroker K, Baust K, et al. Brief Internet-based intervention reduces posttraumatic stress and prolonged grief in parents after the loss of a child during pregnancy: A randomized controlled trial. Psychother Psychosom. 2013;82:372-81. three in Australia,3030. Klein B, Mitchell J, Abbott J, Shandley K, Austin D, Gilson K. A therapist-assisted cognitive behavior therapy internet intervention for posttraumatic stress disorder: Pre-, post- and 3-month follow-up results from an open trial. J Anxiety Disord. 2010;24:635-44.

31. Klein B, Mitchell J, Gilson K, Shandley K, Austin D, Kiropoulos L, et al. A therapist-assisted Internet-based CBT intervention for posttraumatic stress disorder: Preliminary results. Cogn Behav Ther. 2009;38:121-31.
-3232. Spence J, Titov N, Dear BF, Johnston L, Solley K, Lorian C, et al. Randomized controlled trial of Internet-delivered cognitive behavioral therapy for posttraumatic stress disorder. Depress Anxiety. 2011;28:541-50. two in Canada,2323. Germain V, Marchand A, Bouchard S, Drouin MS, Guay S. Effectiveness of cognitive behavioural therapy administered by videoconference for posttraumatic stress disorder. Cogn Behav Ther. 2009;38:42-53.,2424. O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? results from a randomized controlled equivalence trial. Psychiatric Serv. 2007;58:836-43. and the remainder were one each from China,3333. Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, A web-based intervention for traumatized persons in two parallel samples: Randomized controlled trial. J Med Internet Res. 2013;15:e213. Iraq,3434. Knaevelsrud C, Brand J, Lange A, Ruwaard J, Wagner B. Web-based psychotherapy for posttraumatic stress disorder in war-traumatized Arab patients: Randomized controlled trial. J Med Internet Res. 2015;17:e71. the Netherlands,3535. Lange A, Rietdijk D, Hudcovicova M, van de Ven JP, Schrieken B, Emmelkamp PM. Interapy: a controlled randomized trial of the standardized treatment of posttraumatic stress through the internet. J Consult Clin Psychol. 2003;71:901-9. the United States of America,3636. Engel CC, Litz B, Magruder KM, Harper E, Gore K, Stein N, et al. Delivery of self training and education for stressful situations (DESTRESS-PC): A randomized trial of nurse assisted online self-management for PTSD in primary care. Gen Hosp Psychiatry. 2016;37:323-8. and Sweden.3737. Ivarsson D, Blom M, Hesser H, Carlbring P, Enderby P. Guided internet-delivered cognitive behavior therapy for post-traumatic: A randomized controlled trial. Internet Interventions. 2014;1:33-40.

Effectiveness and quality of therapy

Fourteen of the studies evaluated documented that the effectiveness of telepsychiatry was similar to that of face-to-face therapy, although with varying levels of improvements (Table 1).

Table 1
Summary of telepsychiatry studies included in the review

Germain et al. compared CBT administered to PTSD patients face to face and through teleconference for 16-25 weeks and reported a significant reduction in frequency and severity of PTSD symptoms in both groups post-therapy. No significant differences in effectiveness were found between both groups.2323. Germain V, Marchand A, Bouchard S, Drouin MS, Guay S. Effectiveness of cognitive behavioural therapy administered by videoconference for posttraumatic stress disorder. Cogn Behav Ther. 2009;38:42-53.,2424. O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? results from a randomized controlled equivalence trial. Psychiatric Serv. 2007;58:836-43.,3333. Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, A web-based intervention for traumatized persons in two parallel samples: Randomized controlled trial. J Med Internet Res. 2013;15:e213. In a similar study by Klein et al. using online CBT, 69.2% of PTSD patients showed significant post-therapy improvements in symptoms; that number increased to 77% at 3 months’ post-therapy follow-up.3030. Klein B, Mitchell J, Abbott J, Shandley K, Austin D, Gilson K. A therapist-assisted cognitive behavior therapy internet intervention for posttraumatic stress disorder: Pre-, post- and 3-month follow-up results from an open trial. J Anxiety Disord. 2010;24:635-44.

Even when different PTSD inventories (e.g., PTSD Scale, the World Health Organization Quality of Life instrument-Abbreviated version, the Beck Depression Inventory, etc.) were used to compare therapy results, telepsychiatry was still shown to provide significantly better outcomes compared to the control groups.2323. Germain V, Marchand A, Bouchard S, Drouin MS, Guay S. Effectiveness of cognitive behavioural therapy administered by videoconference for posttraumatic stress disorder. Cogn Behav Ther. 2009;38:42-53.

24. O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? results from a randomized controlled equivalence trial. Psychiatric Serv. 2007;58:836-43.

25. Wagner B, Schulz W, Knaevelsrud C. Efficacy of an Internet-based intervention for posttraumatic stress disorder in Iraq: A pilot study. Psychiatry Res. 2012;195:85-8.

26. Wagner B, Brand J, Schulz W, Knaevelsrud C. Online working alliance predicts treatment outcome for posttraumatic stress symptoms in Arab war-traumatized patients. Depress Anxiety. 2012;29:646-51.

27. Knaevelsrud C, Maercker A. Long-term effects of an internet-based treatment for posttraumatic stress. Cogn Behav Ther. 2010;39:72-7.

28. Knaevelsrud C, Maercker A. Internet-based treatment for PTSD reduces distress and facilitates the development of a strong therapeutic alliance: a randomized controlled clinical trial. BMC Psychiatry. 2007;7:13.

29. Kersting A, Dolemeyer R, Steinig J, Walter F, Kroker K, Baust K, et al. Brief Internet-based intervention reduces posttraumatic stress and prolonged grief in parents after the loss of a child during pregnancy: A randomized controlled trial. Psychother Psychosom. 2013;82:372-81.

30. Klein B, Mitchell J, Abbott J, Shandley K, Austin D, Gilson K. A therapist-assisted cognitive behavior therapy internet intervention for posttraumatic stress disorder: Pre-, post- and 3-month follow-up results from an open trial. J Anxiety Disord. 2010;24:635-44.

31. Klein B, Mitchell J, Gilson K, Shandley K, Austin D, Kiropoulos L, et al. A therapist-assisted Internet-based CBT intervention for posttraumatic stress disorder: Preliminary results. Cogn Behav Ther. 2009;38:121-31.

32. Spence J, Titov N, Dear BF, Johnston L, Solley K, Lorian C, et al. Randomized controlled trial of Internet-delivered cognitive behavioral therapy for posttraumatic stress disorder. Depress Anxiety. 2011;28:541-50.

33. Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, A web-based intervention for traumatized persons in two parallel samples: Randomized controlled trial. J Med Internet Res. 2013;15:e213.

34. Knaevelsrud C, Brand J, Lange A, Ruwaard J, Wagner B. Web-based psychotherapy for posttraumatic stress disorder in war-traumatized Arab patients: Randomized controlled trial. J Med Internet Res. 2015;17:e71.

35. Lange A, Rietdijk D, Hudcovicova M, van de Ven JP, Schrieken B, Emmelkamp PM. Interapy: a controlled randomized trial of the standardized treatment of posttraumatic stress through the internet. J Consult Clin Psychol. 2003;71:901-9.

36. Engel CC, Litz B, Magruder KM, Harper E, Gore K, Stein N, et al. Delivery of self training and education for stressful situations (DESTRESS-PC): A randomized trial of nurse assisted online self-management for PTSD in primary care. Gen Hosp Psychiatry. 2016;37:323-8.
-3737. Ivarsson D, Blom M, Hesser H, Carlbring P, Enderby P. Guided internet-delivered cognitive behavior therapy for post-traumatic: A randomized controlled trial. Internet Interventions. 2014;1:33-40.

It should be noted that while there are several psychotherapeutic strategies that are effective in managing PTSD patients, such as CBT, EMDR and prolonged exposure, all studies published so far on telepsychiatry have used CBT. The lack of direct contact between physician and patients, and the use of asynchronized telepsychiatry methods in several studies may hinder the implementation of EMDR or prolonged exposure, as they require active physician feedback. Further studies are hence still required especially on the effectiveness of telepsychiatry combined with these two other treatment methods, as are comparisons between the effectiveness of all three methods when delivered through telepsychiatry.

Effectiveness in specific patient groups

The use of telepsychiatry for PTSD has also been studied in specific patient groups, with telepsychiatry being found effective on both the elderly and children, for instance.3838. Malhotra S, Chakrabarti S, Shah R. Telepsychiatry: Promise, potential, and challenges. Indian J Psychiatry. 2013;55:3-11. Likewise, the method has been tested in both urban and rural areas3333. Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, A web-based intervention for traumatized persons in two parallel samples: Randomized controlled trial. J Med Internet Res. 2013;15:e213. and found to be effective. Its use has also been found to be effective in studies conducted in various regions such as the Middle East,2525. Wagner B, Schulz W, Knaevelsrud C. Efficacy of an Internet-based intervention for posttraumatic stress disorder in Iraq: A pilot study. Psychiatry Res. 2012;195:85-8.,2626. Wagner B, Brand J, Schulz W, Knaevelsrud C. Online working alliance predicts treatment outcome for posttraumatic stress symptoms in Arab war-traumatized patients. Depress Anxiety. 2012;29:646-51. Asia,3333. Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, A web-based intervention for traumatized persons in two parallel samples: Randomized controlled trial. J Med Internet Res. 2013;15:e213. Europe,2828. Knaevelsrud C, Maercker A. Internet-based treatment for PTSD reduces distress and facilitates the development of a strong therapeutic alliance: a randomized controlled clinical trial. BMC Psychiatry. 2007;7:13.,3535. Lange A, Rietdijk D, Hudcovicova M, van de Ven JP, Schrieken B, Emmelkamp PM. Interapy: a controlled randomized trial of the standardized treatment of posttraumatic stress through the internet. J Consult Clin Psychol. 2003;71:901-9. America,3636. Engel CC, Litz B, Magruder KM, Harper E, Gore K, Stein N, et al. Delivery of self training and education for stressful situations (DESTRESS-PC): A randomized trial of nurse assisted online self-management for PTSD in primary care. Gen Hosp Psychiatry. 2016;37:323-8. and Australia.3030. Klein B, Mitchell J, Abbott J, Shandley K, Austin D, Gilson K. A therapist-assisted cognitive behavior therapy internet intervention for posttraumatic stress disorder: Pre-, post- and 3-month follow-up results from an open trial. J Anxiety Disord. 2010;24:635-44.

31. Klein B, Mitchell J, Gilson K, Shandley K, Austin D, Kiropoulos L, et al. A therapist-assisted Internet-based CBT intervention for posttraumatic stress disorder: Preliminary results. Cogn Behav Ther. 2009;38:121-31.
-3232. Spence J, Titov N, Dear BF, Johnston L, Solley K, Lorian C, et al. Randomized controlled trial of Internet-delivered cognitive behavioral therapy for posttraumatic stress disorder. Depress Anxiety. 2011;28:541-50. Finally, telepsychiatry was able to manage PTSD regardless of the triggering event, and has been tested on patients with PTSD caused by war (veterans),2525. Wagner B, Schulz W, Knaevelsrud C. Efficacy of an Internet-based intervention for posttraumatic stress disorder in Iraq: A pilot study. Psychiatry Res. 2012;195:85-8.,2626. Wagner B, Brand J, Schulz W, Knaevelsrud C. Online working alliance predicts treatment outcome for posttraumatic stress symptoms in Arab war-traumatized patients. Depress Anxiety. 2012;29:646-51.,3434. Knaevelsrud C, Brand J, Lange A, Ruwaard J, Wagner B. Web-based psychotherapy for posttraumatic stress disorder in war-traumatized Arab patients: Randomized controlled trial. J Med Internet Res. 2015;17:e71.,3636. Engel CC, Litz B, Magruder KM, Harper E, Gore K, Stein N, et al. Delivery of self training and education for stressful situations (DESTRESS-PC): A randomized trial of nurse assisted online self-management for PTSD in primary care. Gen Hosp Psychiatry. 2016;37:323-8.,3939. US Department of Veteran Affairs. US Department of Veteran Affairs [online]. 2016 [cited 2018 Oct 24]. http://www.ptsd.va.gov/public/materials/apps/PTSDCoach.asp
http://www.ptsd.va.gov/public/materials/...
natural disasters,3333. Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, A web-based intervention for traumatized persons in two parallel samples: Randomized controlled trial. J Med Internet Res. 2013;15:e213. post-partum,2929. Kersting A, Dolemeyer R, Steinig J, Walter F, Kroker K, Baust K, et al. Brief Internet-based intervention reduces posttraumatic stress and prolonged grief in parents after the loss of a child during pregnancy: A randomized controlled trial. Psychother Psychosom. 2013;82:372-81. and other types of traumas.

Similarly to other psychiatric disorders, PTSD still raises stigma in many areas of the world. Hence, patients may fear seeking direct help and attend face-to-face consultations with mental health professionals even when they are accessible. Telepsychiatry can help in managing these patients as it can provide a secure and private environment to patients, from the comfort of their own place. This may help patients be more eager to seek help and increase interaction with mental health professionals.

Long-term effects

For telepsychiatry to be feasible, it should not only provide acute improvements but also remain effective in the long run. In the RCT conducted by Klein et al., at 3 months post-telepsychiatry for 10 weeks, 77% of the patients still reported improvements in their PTSD severity, with good patient satisfaction and an average doctor-patient interaction of fewer than 200 minutes.3030. Klein B, Mitchell J, Abbott J, Shandley K, Austin D, Gilson K. A therapist-assisted cognitive behavior therapy internet intervention for posttraumatic stress disorder: Pre-, post- and 3-month follow-up results from an open trial. J Anxiety Disord. 2010;24:635-44.

Furthermore, in another RCT led by Ivarsson et al. involving PTSD patients and using a fully Internet-based module, without any direct doctor-patient interaction, significant improvement in depression and anxiety as well as in post-therapy quality of life was reported, persisting even 1 year post-therapy.3737. Ivarsson D, Blom M, Hesser H, Carlbring P, Enderby P. Guided internet-delivered cognitive behavior therapy for post-traumatic: A randomized controlled trial. Internet Interventions. 2014;1:33-40. The study by Kersting et al. also reported similar improvement in symptoms remaining for one year post-therapy.2929. Kersting A, Dolemeyer R, Steinig J, Walter F, Kroker K, Baust K, et al. Brief Internet-based intervention reduces posttraumatic stress and prolonged grief in parents after the loss of a child during pregnancy: A randomized controlled trial. Psychother Psychosom. 2013;82:372-81. Knaevelsrud & Maercker reported that improvement of symptoms remained even at 18 months post-therapy.2727. Knaevelsrud C, Maercker A. Long-term effects of an internet-based treatment for posttraumatic stress. Cogn Behav Ther. 2010;39:72-7.

Effect on quality of doctor-patient relationship and patient satisfaction

One of the main impacts of telepsychiatry is the reduction of doctor-patient interaction. However, as shown in the study by Klein et al., doctor-patient relationship quality was reported to remain high, at 87.5%.3030. Klein B, Mitchell J, Abbott J, Shandley K, Austin D, Gilson K. A therapist-assisted cognitive behavior therapy internet intervention for posttraumatic stress disorder: Pre-, post- and 3-month follow-up results from an open trial. J Anxiety Disord. 2010;24:635-44.

Spence et al. also reported that 81% of telepsychiatry users were satisfied with the care received and 95% would recommend it to others.3232. Spence J, Titov N, Dear BF, Johnston L, Solley K, Lorian C, et al. Randomized controlled trial of Internet-delivered cognitive behavioral therapy for posttraumatic stress disorder. Depress Anxiety. 2011;28:541-50. Knaelvelsrud et al. also reported a low dropout rate in the telepsychiatry group (16%) and that 86% of users reported being satisfied.2828. Knaevelsrud C, Maercker A. Internet-based treatment for PTSD reduces distress and facilitates the development of a strong therapeutic alliance: a randomized controlled clinical trial. BMC Psychiatry. 2007;7:13. Furthermore, the study by Malhotra et al. involving children even showed a higher satisfaction rate in the telepsychiatry group compared to the face-to-face therapy group.3838. Malhotra S, Chakrabarti S, Shah R. Telepsychiatry: Promise, potential, and challenges. Indian J Psychiatry. 2013;55:3-11. Similar patient satisfaction findings were also reported by O’Reilly et al.2424. O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? results from a randomized controlled equivalence trial. Psychiatric Serv. 2007;58:836-43. and Wagner et al.2626. Wagner B, Brand J, Schulz W, Knaevelsrud C. Online working alliance predicts treatment outcome for posttraumatic stress symptoms in Arab war-traumatized patients. Depress Anxiety. 2012;29:646-51.

Length of therapy

The therapeutic length of telepsychiatry for PTSD differed across the different studies evaluated. Some were performed for as short as 1 month3333. Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, A web-based intervention for traumatized persons in two parallel samples: Randomized controlled trial. J Med Internet Res. 2013;15:e213. while some were 6 months long.2323. Germain V, Marchand A, Bouchard S, Drouin MS, Guay S. Effectiveness of cognitive behavioural therapy administered by videoconference for posttraumatic stress disorder. Cogn Behav Ther. 2009;38:42-53. However, it was shown that a minimum therapy of 1 month was already able to significantly reduce PTSD symptoms, with improvements remaining even post-therapy.3333. Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, A web-based intervention for traumatized persons in two parallel samples: Randomized controlled trial. J Med Internet Res. 2013;15:e213.,3737. Ivarsson D, Blom M, Hesser H, Carlbring P, Enderby P. Guided internet-delivered cognitive behavior therapy for post-traumatic: A randomized controlled trial. Internet Interventions. 2014;1:33-40.

On average, therapeutic time with telepsychiatry was also shorter compared to face-to-face therapy: the study by Klein et al. reported a therapeutic time of around 3 hours with telepsychiatry compared to 12 hours with face-to-face therapy.3030. Klein B, Mitchell J, Abbott J, Shandley K, Austin D, Gilson K. A therapist-assisted cognitive behavior therapy internet intervention for posttraumatic stress disorder: Pre-, post- and 3-month follow-up results from an open trial. J Anxiety Disord. 2010;24:635-44. Shorter therapy durations were reported in other studies with as less as <2 hours in the study by Spence et al.3232. Spence J, Titov N, Dear BF, Johnston L, Solley K, Lorian C, et al. Randomized controlled trial of Internet-delivered cognitive behavioral therapy for posttraumatic stress disorder. Depress Anxiety. 2011;28:541-50. These results were also supported by other authors, such as Wagner et al.2626. Wagner B, Brand J, Schulz W, Knaevelsrud C. Online working alliance predicts treatment outcome for posttraumatic stress symptoms in Arab war-traumatized patients. Depress Anxiety. 2012;29:646-51. and Knaevelsrud et al.3434. Knaevelsrud C, Brand J, Lange A, Ruwaard J, Wagner B. Web-based psychotherapy for posttraumatic stress disorder in war-traumatized Arab patients: Randomized controlled trial. J Med Internet Res. 2015;17:e71.

Web- and application-based telepsychiatry

While telepsychiatry can facilitate remote face-to-face therapy with psychiatrists and psychologists through video conferencing, its greatest utility to provide treatment for the masses lies in the use of specialty software designed for patient self-help in managing PTSD. Software can be web- or application-based, including a step by step PTSD management curriculum for patients. For example, web-based My Trauma Recovery has been proven to be effective when implemented to help manage PTSD among earthquake victims in Wenchuan, China, in the year 2008.3333. Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, A web-based intervention for traumatized persons in two parallel samples: Randomized controlled trial. J Med Internet Res. 2013;15:e213. Telepsychiatry software has also been implemented successfully for other psychiatric disorders, including PTSD, in the Netherlands, through the web-based software Interapy.3535. Lange A, Rietdijk D, Hudcovicova M, van de Ven JP, Schrieken B, Emmelkamp PM. Interapy: a controlled randomized trial of the standardized treatment of posttraumatic stress through the internet. J Consult Clin Psychol. 2003;71:901-9. Mobile applications have also been utilized for the screening and management of PTSD patients, especially post-war veterans in the United States.3939. US Department of Veteran Affairs. US Department of Veteran Affairs [online]. 2016 [cited 2018 Oct 24]. http://www.ptsd.va.gov/public/materials/apps/PTSDCoach.asp
http://www.ptsd.va.gov/public/materials/...
Simpler forms of telepsychiatry such as through e-mail have also been found to be successful, as shown by Klein et al.3131. Klein B, Mitchell J, Gilson K, Shandley K, Austin D, Kiropoulos L, et al. A therapist-assisted Internet-based CBT intervention for posttraumatic stress disorder: Preliminary results. Cogn Behav Ther. 2009;38:121-31.

Cost-efficiency

Only two studies have reported on the economic effects of telepsychiatry use in managing PTSD. Klein et al. reported that telepsychiatry was 3.7 times cheaper compared to face-to-face therapy. The costs of the two modalities were AUD 373 for telepsychiatry and AUD 1,380 for conventional face-to-face therapy.3030. Klein B, Mitchell J, Abbott J, Shandley K, Austin D, Gilson K. A therapist-assisted cognitive behavior therapy internet intervention for posttraumatic stress disorder: Pre-, post- and 3-month follow-up results from an open trial. J Anxiety Disord. 2010;24:635-44. This result was also supported by O’Reilly et al., though at a lesser difference: cost analysis showed that utilizing telepsychiatry would save at least 10% per patient compared to face-to-face therapy (USD 394 vs. 439) and 16% per visit compared to the cost of in-person service (USD 265 vs. 315). This lower cost results from the fact that telepsychiatry reduces the need for travel and accommodation expenses, as well as higher psychiatrist fees to compensate for time lost due to travel. O’Reilly et al. also reported that the savings provided by telepsychiatry were proven to be greater than the technical costs of setting up and maintaining a telepsychiatry system.2424. O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? results from a randomized controlled equivalence trial. Psychiatric Serv. 2007;58:836-43.

Notwithstanding, two studies reporting on an economic analysis of telepsychiatry underscored that these results should be viewed with caution and may not be generalizable to all settings.2424. O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? results from a randomized controlled equivalence trial. Psychiatric Serv. 2007;58:836-43.,3030. Klein B, Mitchell J, Abbott J, Shandley K, Austin D, Gilson K. A therapist-assisted cognitive behavior therapy internet intervention for posttraumatic stress disorder: Pre-, post- and 3-month follow-up results from an open trial. J Anxiety Disord. 2010;24:635-44. For instance, synchronized telepsychiatry is hypothetically most beneficial in settings with a large number of PTSD patients, located in remote or disaster-stricken areas with a low patient-to-mental health professional ratio. In urban areas or developed nations with adequate patient-to-mental health professional ratios, these systems may be more cost-effective compared to face-to-face therapy.2424. O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? results from a randomized controlled equivalence trial. Psychiatric Serv. 2007;58:836-43.

However, the use of web- and application-based asynchronized telepsychiatry as explained earlier may be a cost-effective solution in most settings: even though this modality requires a substantial start-up investment, therapy costs are relatively low in the long run, as they require limited patient/mental health professional interaction. The rise of artificial intelligence systems in the future may further reduce these costs.

Practical implications

The use of telepsychiatry in managing PTSD has been found to provide care for patients with comparable effectiveness and similar patient satisfaction as well as quality of doctor patient relationship when compared with face-to-face therapy.2323. Germain V, Marchand A, Bouchard S, Drouin MS, Guay S. Effectiveness of cognitive behavioural therapy administered by videoconference for posttraumatic stress disorder. Cogn Behav Ther. 2009;38:42-53.,2424. O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? results from a randomized controlled equivalence trial. Psychiatric Serv. 2007;58:836-43.,3333. Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, A web-based intervention for traumatized persons in two parallel samples: Randomized controlled trial. J Med Internet Res. 2013;15:e213.,3838. Malhotra S, Chakrabarti S, Shah R. Telepsychiatry: Promise, potential, and challenges. Indian J Psychiatry. 2013;55:3-11.

Improving accessibility and efficiency remains one of the main reasons for utilizing telepsychiatry. The growth of communication technologies such as the use of wireless technology, satellites, solar technology and fiber optics has made the implementation of telepsychiatry more feasible than ever. Reduced costs and therapeutic time as reported by various studies are also important benefits. Still, these results should be taken with caution, as only a few studies have evaluated the cost-effectiveness of telepsychiatry interventions. The lack of studies conducted in developing and less technologically developed areas are also concerning, as there may be additional setup costs and training required before telepsychiatry systems can be developed in these areas.

It is believed that telepsychiatry can improve not only the management of PTSD, but also screening and early diagnosis, as currently implemented by the Department of Veteran Affairs in the United States, and also for post-disaster areas, such as in Pakistan.4040. Norris AC. Essentials of Telemedicine and Telecare. West Sussex: John Wiley and Sons; 2002.,4141. Ministry of Information and Technology Pakistan. Telemedicine: MoIT- Health Net [online]. 2008 [cited 2018 Oct 24]. http://www.telemedicine.pk/disaster%20management.html
http://www.telemedicine.pk/disaster%20ma...
To date, the majority of studies originate from developed nations, especially Europe, and further studies are needed to examine the efficacy of telepsychiatry in developing and underdeveloped nations in Asia and Africa, which are lacking in psychiatric services.

Similarly to the implementation of new technologies in other fields, the application of telepsychiatry still faces several barriers, including limited connectivity, lack of human resources and lack of telepsychiatry equipment. In addition, e-health guidelines and regulations need to be developed to address issues such as doctor-patient confidentiality, data privacy, etc. This review has shown that studies tend to focus only on parameters of efficacy, rarely analyzing the economic aspects of telepsychiatry (only two studies provided an economic analysis). Therefore, economic feasibility remains an important aspect to look into, especially when considering the implementation of telepsychiatry in developing nations and the coverage of this system by insurance plans. When these barriers can be addressed, the implementation of telepsychiatry could hopefully be able to make treatment for PTSD and other psychiatric disorders more affordable and reachable to the masses.

Limitations

This review article suffers limitations in only being able to synthesize previously published journal articles and trials that are accessible to the authors. It should be noted that the studies included were based on published reports and take into account that studies reporting positive results are more readily accepted for publication as compared with studies reporting negative results. Also, most studies reviewed originate from developed countries, and there is a lack of studies reporting on telepsychiatry use in developing nations such as Asia and Africa, where it is best utilized to help bridge the currently low patient-to-mental health professional ratio. Furthermore, studies on its utilization in less technologically developed areas, with low literacy rates, as well as remote in location are also lacking in number.

Conclusions

Various studies have pointed to telepsychiatry as an effective and efficient way to manage PTSD. The quality of care given by telepsychiatry, both through video conferencing and web- and application-based, is comparable to that of face-to-face therapy, although most studies published so far are from developed nations. Patient satisfaction and quality of doctor-patient relationship also remain high, with therapeutic time comparable to that of face-to-face therapy. Countries, especially those with a low patient-to-mental health professional ratio, should be encouraged to develop telepsychiatry systems to manage PTSD.

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Publication Dates

  • Publication in this collection
    17 Apr 2020
  • Date of issue
    Jan-Mar 2020

History

  • Received
    22 Mar 2019
  • Accepted
    17 June 2019
Associação de Psiquiatria do Rio Grande do Sul Av. Ipiranga, 5311/202, 90610-001 Porto Alegre RS/ Brasil, Tel./Fax: (55 51) 3024 4846 - Porto Alegre - RS - Brazil
E-mail: trends@aprs.org.br