einstein (São Paulo)https://www.scielo.br/journal/eins/feed/2024-03-05T21:07:24.640000ZVol. 22 - 2024WerkzeugHealth and lifestyle parameters in peripheral artery disease at two periods of the COVID-19 pandemic: comparison between men and women10.31744/einstein_journal/2024AO03452024-03-05T21:07:24.640000Z2020-08-09T06:48:29.851000ZKanegusuku, HélcioSilva, Gustavo Oliveira daBraghieri, Heloisa AmaralCarvalho, Juliana Ferreira deCosta, Renan MassenaCucato, Gabriel GrizzoWolosker, NelsonRitti-Dias, Raphael MendesCorreia, Marilia Almeida
<em>Kanegusuku, Hélcio</em>;
<em>Silva, Gustavo Oliveira Da</em>;
<em>Braghieri, Heloisa Amaral</em>;
<em>Carvalho, Juliana Ferreira De</em>;
<em>Costa, Renan Massena</em>;
<em>Cucato, Gabriel Grizzo</em>;
<em>Wolosker, Nelson</em>;
<em>Ritti-Dias, Raphael Mendes</em>;
<em>Correia, Marilia Almeida</em>;
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ABSTRACT Objective: This study analyzed the impact of sex on self-reported health and lifestyle parameters in peripheral artery disease patients at two periods of the COVID-19 pandemic. Methods: In this longitudinal study, 99 patients with peripheral artery disease (53 men and 46 women) were evaluated during two periods of the COVID-19 pandemic ( i.e ., at onset: May to August 2020, and on follow-up: May to August 2021). Patients were interviewed via telephone, and information regarding lifestyle and health parameters was obtained. Results: At the onset of the COVID-19 pandemic, health and habit parameters were similar between women and men, with 63.0% and 45.3% indicating frequent fatigue, 73.9% and 84.9% reporting increased sitting time, and 23.9% and 39.6% practicing physical activity, respectively. At follow-up, difficulties in physical mobility (women: from 26.1% to 73.9%, p<0.001; men: from 39.6% to 71.7%, p=0.001) and the frequency of hospitalization for reasons other than COVID-19 increased similarly in women and men (women: from 4.3% to 21.7%, p=0.013; men: from 9.4% to 24.5%, p=0.038). The other parameters were similar between the periods. Conclusion: Self-reported physical mobility difficulties and hospitalization frequency increased in women and men with peripheral artery disease.Is it possible to estimate the number of patients with COVID-19 admitted to intensive care units and general wards using clinical and telemedicine data?10.31744/einstein_journal/2024AO03282024-03-05T21:07:24.640000Z2020-08-09T06:48:29.851000ZGabaldi, Caio QuerinoCypriano, Adriana SerraPedrotti, Carlos Henrique SartoratoMalheiro, Daniel TavaresLaselva, Claudia ReginaCendoroglo Neto, MiguelTeich, Vanessa Damazio
<em>Gabaldi, Caio Querino</em>;
<em>Cypriano, Adriana Serra</em>;
<em>Pedrotti, Carlos Henrique Sartorato</em>;
<em>Malheiro, Daniel Tavares</em>;
<em>Laselva, Claudia Regina</em>;
<em>Cendoroglo Neto, Miguel</em>;
<em>Teich, Vanessa Damazio</em>;
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GRAPHICAL ABSTRACTNew immunological aspects of peri-implantitis10.31744/einstein_journal/2024AO03962024-03-05T21:07:24.640000Z2020-08-09T06:48:29.851000ZBertoldo, Bárbara BellocchioPaulo, Guilherme OliveiraFurtado, Taíssa Cássia de SouzaPereira, Thiago LimaRodrigues Junior, VirmondesRodrigues, Denise Bertulucci Rochade Faria, Juliana BarbosaRosa, Rodrigo CésarPereira, Sanívia Aparecida de Lima
<em>Bertoldo, Bárbara Bellocchio</em>;
<em>Paulo, Guilherme Oliveira</em>;
<em>Furtado, Taíssa Cássia De Souza</em>;
<em>Pereira, Thiago Lima</em>;
<em>Rodrigues Junior, Virmondes</em>;
<em>Rodrigues, Denise Bertulucci Rocha</em>;
<em>De Faria, Juliana Barbosa</em>;
<em>Rosa, Rodrigo César</em>;
<em>Pereira, Sanívia Aparecida De Lima</em>;
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GRAPHICAL ABSTRACTA molecular approach to triple-negative breast cancer: targeting the Notch signaling pathway10.31744/einstein_journal/2024RW05522024-03-05T21:07:24.640000Z2020-08-09T06:48:29.851000ZPardo, IsabeleFagundes, Pedro BrecheretOliveira, Rafael Santana deCampregher, Paulo Vidal
<em>Pardo, Isabele</em>;
<em>Fagundes, Pedro Brecheret</em>;
<em>Oliveira, Rafael Santana De</em>;
<em>Campregher, Paulo Vidal</em>;
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ABSTRACT Introduction Triple-negative breast cancer is an aggressive subtype of breast cancer characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. This phenotype renders triple-negative breast cancer cells refractory to conventional therapies, resulting in poor clinical outcomes and an urgent need for novel therapeutic approaches. Recent studies have implicated dysregulation of the Notch receptor signaling pathway in the development and progression of triple-negative breast cancer. Objective This study aimed to conduct a comprehensive literature review to identify potential therapeutic targets of the Notch pathway. Our analysis focused on the upstream and downstream components of this pathway to identify potential therapeutic targets. Results Modulating the Notch signaling pathway may represent a promising therapeutic strategy to treat triple-negative breast cancer. Several potential therapeutic targets within this pathway are in the early stages of development, including upstream (such as Notch ligands) and downstream (including specific molecules involved in triple-negative breast cancer growth). These targets represent potential avenues for therapeutic intervention in triple-negative breast cancer. Comments Additional research specifically addressing issues related to toxicity and improving drug delivery methods is critical for the successful translation of these potential therapeutic targets into effective treatments for patients with triple-negative breast cancer.Telemedicine and patients with heart failure: evidence and unresolved issues10.31744/einstein_journal/2024RW03932024-03-05T21:07:24.640000Z2020-08-09T06:48:29.851000ZAccorsi, Tarso Augusto DuenhasSantos, Gabriela Guimarães Rodrigues dosNemoto, Renato PaladinoMoreira, Flavio TocciDe Amicis, KarineKöhler, Karen FrancineCordioli, EduardoPedrotti, Carlos Henrique Sartorato
<em>Accorsi, Tarso Augusto Duenhas</em>;
<em>Santos, Gabriela Guimarães Rodrigues Dos</em>;
<em>Nemoto, Renato Paladino</em>;
<em>Moreira, Flavio Tocci</em>;
<em>De Amicis, Karine</em>;
<em>Köhler, Karen Francine</em>;
<em>Cordioli, Eduardo</em>;
<em>Pedrotti, Carlos Henrique Sartorato</em>;
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ABSTRACT Heart failure is the leading cause of cardiac-related hospitalizations. Limited access to reevaluations and outpatient appointments restricts the application of modern therapies. Telemedicine has become an essential resource in the healthcare system because of its countless benefits, such as higher and more frequent appointments and faster titration of medications. This narrative review aimed to demonstrate the evidence and unresolved issues related to the use of telemedicine in patients with heart failure. No studies have examined heart failure prevention; however, several studies have addressed the prevention of decompensation with positive results. Telemedicine can be used to evaluate all patients with heart failure, and many telemedicine platforms are available. Several strategies, including both noninvasive (phone calls, weight measurement, and virtual visits) and invasive (implantable pulmonary artery catheters) strategies can be implemented. Given these benefits, telemedicine is highly desirable, particularly for vulnerable groups. Although some questions remain unanswered, the development of new technologies can complement remote visits and improve patient care.Littoral cell angioma of the spleen: case report and literature review10.31744/einstein_journal/2024RC02672024-03-05T21:07:24.640000Z2020-08-09T06:48:29.851000ZMachado Júnior, Paulo André BispoPereira, Caroline de OliveiraBortolo, Julia Letícia deMartins, Ana Luísa Caetano LopesCampos, Helder GroenwoldAguiar, Alan Junior dePostai, Rayana Pecharki Teixeira AlvesWiederkehr, Julio CesarWiederkehr, Henrique de Aguiar
<em>Machado Júnior, Paulo André Bispo</em>;
<em>Pereira, Caroline De Oliveira</em>;
<em>Bortolo, Julia Letícia De</em>;
<em>Martins, Ana Luísa Caetano Lopes</em>;
<em>Campos, Helder Groenwold</em>;
<em>Aguiar, Alan Junior De</em>;
<em>Postai, Rayana Pecharki Teixeira Alves</em>;
<em>Wiederkehr, Julio Cesar</em>;
<em>Wiederkehr, Henrique De Aguiar</em>;
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ABSTRACT Littoral cell angioma is an extremely rare splenic vascular tumor originating from the cells lining the splenic red pulp sinuses. Approximately 150 cases of littoral cell angioma have been reported since 1991. Its clinical manifestation is usually asymptomatic and is mostly diagnosed as an incidental finding through abdominal imaging. Herein, we present a case of littoral cell angioma in a 41-year-old woman with no previous comorbidities, which initially presented as a nonspecific splenic lesion diagnosed on imaging in the emergency room. The patient was treated through laparoscopic intervention.Benign cervical schwannoma with tracheal invasion10.31744/einstein_journal/2024RC05282024-03-05T21:07:24.640000Z2020-08-09T06:48:29.851000ZLorandi, Leonardo LimaCeccon, Fabio PupoCallegari, Fabiano MesquitaBacchi, Carlos EduardoHaddad, Leonardo
<em>Lorandi, Leonardo Lima</em>;
<em>Ceccon, Fabio Pupo</em>;
<em>Callegari, Fabiano Mesquita</em>;
<em>Bacchi, Carlos Eduardo</em>;
<em>Haddad, Leonardo</em>;
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ABSTRACT Schwannomas commonly develop in the cervical region, 25% – 45% of cases are diagnosed in this anatomical region. Tracheal neurogenic tumors are exceedingly rare and can be misdiagnosed as invasive thyroid carcinomas or other infiltrating malignancies when present at the level of the thyroid gland. Here, we present a case of synchronous benign cervical schwannoma with tracheal invasion and papillary thyroid carcinoma in a patient who was initially hospitalized for COVID-19. The patient presented with dyspnea that was later found to be caused by tracheal extension of a cervical tumor. Surgical excision was performed, and the surgical team proceeded with segmental tracheal resection, removal of the cervical mass, and total thyroidectomy. The specimen was sent for pathological analysis, which revealed synchronous findings of a benign cervical schwannoma with tracheal invasion and papillary thyroid carcinoma. The literature on this subject, together with the present case report, suggests that neurogenic tumors should be included in the differential diagnosis of obstructing tracheal cervical masses. Surgical excision is the first-line of treatment for benign cervical schwannomas.Cardiac troponin T (cTnT) assessment using incompletely filled K<sub>2</sub>EDTA blood tubes is reliable10.31744/einstein_journal/2024CE06132024-03-05T21:07:24.640000Z2020-08-09T06:48:29.851000ZLippi, GiuseppeSalvagno, Gian Luca
<em>Lippi, Giuseppe</em>;
<em>Salvagno, Gian Luca</em>;
<br/><br/>