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Revista Brasileira de Ciências Farmacêuticas

Print version ISSN 1516-9332


BALBINO, Carlos Aberto; PEREIRA, Leonardo Madeira  and  CURI, Rui. Mechanisms involved in wound healing: a revision. Rev. Bras. Cienc. Farm. [online]. 2005, vol.41, n.1, pp.27-51. ISSN 1516-9332.

The mechanisms involved in tissue repair are revised. The wound healing process occurs basically in three phases: inflammation, formation of granulating tissue and extracellular tissue deposition, and tissue remodeling. The cellular and tissue events of each phase are described and discussed. The chemical mediators and their interplay with the wound healing events and cells involved are also discussed. However, especial attention was given to the role played by the growth factors in the tissue repair process.

Keywords : Wound healing; Leukocytes; Fibroblasts; Keratinocytes; Platelets; Growth factors; Cytokines.

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