SciELO - Scientific Electronic Library Online

 
vol.87 issue2Diet of the chola guitarfish, Rhinobatos percellens (Rhinobatidae), in the Paranaguá Estuarine complexChemical compositions and termiticidal activities of the heartwood from Calophyllum inophyllum L. author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Anais da Academia Brasileira de Ciências

Print version ISSN 0001-3765On-line version ISSN 1678-2690

Abstract

ANTINARELLI, Luciana M.R.; PINTO, Nícolas C.; SCIO, Elita  and  COIMBRA, Elaine S.. Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris. An. Acad. Bras. Ciênc. [online]. 2015, vol.87, n.2, pp.733-742.  Epub June 09, 2015. ISSN 1678-2690.  https://doi.org/10.1590/0001-3765201520140288.

Leishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for several diseases is based mainly on the use of traditional herbal remedies. In this work, the cytotoxic activity of 17 plant methanol extracts was evaluated on several Leishmania species and murine macrophages. Among them, the extract of Casearia sylvestris, Piptocarpha macropoda, Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed a promissing leishmanicidal activity, exhibiting IC50 values below of 20 µg/mL against at least one species of Leishmania. Casearia sylvestris showed the most expressive activity against all promastigote forms of Leishmania species (IC50 values of 5.4 µg/mL, 5.0 µg/mL, 8.5 µg/mL and 7.7 µg/mL for L. amazonensis, L. braziliensis, L. chagasi and L. major, respectively), being more effective than the reference drug miltefosine. In spite of the cytotoxic effect on macrophages (CC50 value of 5.2 µg/mL), C. sylvestris exhibited a strong inhibition against intracellular amastigotes of L. braziliensis (IC50 value of 1.3 µg/mL). Further studies, including bio-guided fractionation will be conducted to identify the active compounds.

Keywords : Brazil; Casearia sylvestris; leishmanicidal activity; medicinal plants; natural products.

        · abstract in Portuguese     · text in English     · English ( pdf )