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vol.51 número7Densidade mineral óssea de crianças e adolescentes com hipotireoidismo congênitoAnálise molecular de PROP1, PIT1, HESX1, LHX3 e LHX4 mostra alta freqüência de mutações no PROP1 em pacientes com formas familiares de deficiência combinada de hormônios hipofisários índice de autoresíndice de assuntospesquisa de artigos
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Arquivos Brasileiros de Endocrinologia & Metabologia

versão On-line ISSN 1677-9487


MARCHISOTTI, Frederico G. et al. Growth hormone (GH) deficiency treatment in children: comparison between uses of pen versus bottles/syringes on GH administration. Arq Bras Endocrinol Metab [online]. 2007, vol.51, n.7, pp.1093-1096. ISSN 1677-9487.

The aim of this study was to compare two preparations of recombinant human GH (rGH) in the treatment of GH deficient patients. Ten prepubertal GH-deficient children were followed during 6 months. They received injections with syringe for 3 months, followed by pen administration for the subsequent 3 months. Acceptability was evaluated through a questionnaire. Waste of medication was calculated by the difference between the number of used bottles or refills and the calculated amount for the period. Treatment response was evaluated by SDS gain of height measured each 3 months. After 6 months, 90% of patients/family members declared they preferred the pen regarding technical facility and local pain, and all patients considered the pen easier to transport and store. The waste of medication was lower with pen administration, as was the final cost. We concluded that pen-administered rGH treatment is more convenient, better accepted by the patients, and leads to less waste of medication when compared to the syringe administration.

Palavras-chave : Treatment; Children; Deficiency; Growth hormone; Pen.

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