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Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487

Abstract

LIBERATORE JUNIOR, Raphael Del Roio et al. Hyperinsulinemic hypoglycemia of the infancy: Analysis of clinical data from a Brazilian sample . Arq Bras Endocrinol Metab [online]. 2012, vol.56, n.9, pp.666-671. ISSN 1677-9487.  https://doi.org/10.1590/S0004-27302012000900011.

OBJECTIVE: To review the presentation of hyperinsulinemic hypoglycemia of the infancy (HHI), its treatment and histology in Brazilian pediatric endocrinology sections. MATERIALS AND METHOD: The protocol analyzed data of birth, laboratory results, treatment, surgery, and pancreas histology. RESULTS: Twenty-five cases of HHI from six centers were analyzed: 15 male, 3/25 born by vaginal delivery. The average age at diagnosis was 10.3 days. Glucose and insulin levels in the critical sample showed an average of 24.7 mg/dL and 26.3 UI/dL. Intravenous infusion of the glucose was greater than 10 mg/kg/min in all cases (M:19,1). Diazoxide was used in 15/25 of the cases, octreotide in 10, glucocorticoid in 8, growth hormone in 3, nifedipine in 2 and glucagon in 1. Ten of the cases underwent pancreatectomy and histology results showed the diffuse form of disease. CONCLUSION: This is the first critic review of a Brazilian sample with congenital HHI. Arq Bras Endocrinol Metab. 2012;56(9):666-71

Keywords : Hypoglycemia, congenital; hyperinsulinemic hypoglycemia of the infancy; hyperinsulinism; nesidioblastosis.

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