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Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487


BRUDER-NASCIMENTO, Thiago et al. Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats. Arq Bras Endocrinol Metab [online]. 2013, vol.57, n.8, pp.642-649. ISSN 1677-9487.

OBJECTIVE: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. MATERIALS AND METHODS: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%. RESULTS: The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet. CONCLUSION: Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet.

Keywords : Chronic stress; high-fat diet; calorie intake and food intake.

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